Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Evavold, Charles L., Hafner-Bratkovič, Iva, Devant, Pascal, D’Andrea, Jasmin M., Ngwa, Elsy M., Boršić, Elvira, Doench, John G., LaFleur, Martin W., Sharpe, Arlene H., Thiagarajah, Jay R., Kagan, Jonathan C.
Published in Cell (19.08.2021)
Published in Cell (19.08.2021)
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Inhibitors of the PD-1 Pathway in Tumor Therapy
LaFleur, Martin W, Muroyama, Yuki, Drake, Charles G, Sharpe, Arlene H
Published in The Journal of immunology (1950) (15.01.2018)
Published in The Journal of immunology (1950) (15.01.2018)
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LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
Sheng, Wanqiang, LaFleur, Martin W., Nguyen, Thao H., Chen, Sujun, Chakravarthy, Ankur, Conway, Jake Ryan, Li, Ying, Chen, Hao, Yang, Henry, Hsu, Pang-Hung, Van Allen, Eliezer M., Freeman, Gordon J., De Carvalho, Daniel D., He, Housheng Hansen, Sharpe, Arlene H., Shi, Yang
Published in Cell (26.07.2018)
Published in Cell (26.07.2018)
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Ringel, Alison E., Drijvers, Jefte M., Baker, Gregory J., Catozzi, Alessia, García-Cañaveras, Juan C., Gassaway, Brandon M., Miller, Brian C., Juneja, Vikram R., Nguyen, Thao H., Joshi, Shakchhi, Yao, Cong-Hui, Yoon, Haejin, Sage, Peter T., LaFleur, Martin W., Trombley, Justin D., Jacobson, Connor A., Maliga, Zoltan, Gygi, Steven P., Sorger, Peter K., Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.
Published in Cell (23.12.2020)
Published in Cell (23.12.2020)
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PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity
Juneja, Vikram R, McGuire, Kathleen A, Manguso, Robert T, LaFleur, Martin W, Collins, Natalie, Haining, W Nicholas, Freeman, Gordon J, Sharpe, Arlene H
Published in The Journal of experimental medicine (03.04.2017)
Published in The Journal of experimental medicine (03.04.2017)
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Journal Article
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
Miller, Brian C., Sen, Debattama R., Al Abosy, Rose, Bi, Kevin, Virkud, Yamini V., LaFleur, Martin W., Yates, Kathleen B., Lako, Ana, Felt, Kristen, Naik, Girish S., Manos, Michael, Gjini, Evisa, Kuchroo, Juhi R., Ishizuka, Jeffrey J., Collier, Jenna L., Griffin, Gabriel K., Maleri, Seth, Comstock, Dawn E., Weiss, Sarah A., Brown, Flavian D., Panda, Arpit, Zimmer, Margaret D., Manguso, Robert T., Hodi, F. Stephen, Rodig, Scott J., Sharpe, Arlene H., Haining, W. Nicholas
Published in Nature immunology (01.03.2019)
Published in Nature immunology (01.03.2019)
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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
Manguso, Robert T., Pope, Hans W., Zimmer, Margaret D., Brown, Flavian D., Yates, Kathleen B., Miller, Brian C., Collins, Natalie B., Bi, Kevin, LaFleur, Martin W., Juneja, Vikram R., Weiss, Sarah A., Lo, Jennifer, Fisher, David E., Miao, Diana, Van Allen, Eliezer, Root, David E., Sharpe, Arlene H., Doench, John G., Haining, W. Nicholas
Published in Nature (London) (27.07.2017)
Published in Nature (London) (27.07.2017)
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Journal Article
The epigenetic landscape of T cell exhaustion
Sen, Debattama R., Kaminski, James, Barnitz, R. Anthony, Kurachi, Makoto, Gerdemann, Ulrike, Yates, Kathleen B., Tsao, Hsiao-Wei, Godec, Jernej, LaFleur, Martin W., Brown, Flavian D., Tonnerre, Pierre, Chung, Raymond T., Tully, Damien C., Allen, Todd M., Frahm, Nicole, Lauer, Georg M., Wherry, E. John, Yosef, Nir, Haining, W. Nicholas
Published in Science (American Association for the Advancement of Science) (02.12.2016)
Published in Science (American Association for the Advancement of Science) (02.12.2016)
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Journal Article
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity
LaFleur, Martin W., Nguyen, Thao H., Coxe, Matthew A., Miller, Brian C., Yates, Kathleen B., Gillis, Jacob E., Sen, Debattama R., Gaudiano, Emily F., Al Abosy, Rose, Freeman, Gordon J., Haining, W. Nicholas, Sharpe, Arlene H.
Published in Nature immunology (01.10.2019)
Published in Nature immunology (01.10.2019)
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Journal Article
Targeting PD-L2–RGMb overcomes microbiome-related immunotherapy resistance
Park, Joon Seok, Gazzaniga, Francesca S., Wu, Meng, Luthens, Amalia K., Gillis, Jacob, Zheng, Wen, LaFleur, Martin W., Johnson, Sarah B., Morad, Golnaz, Park, Elizabeth M., Zhou, Yifan, Watowich, Stephanie S., Wargo, Jennifer A., Freeman, Gordon J., Kasper, Dennis L., Sharpe, Arlene H.
Published in Nature (London) (11.05.2023)
Published in Nature (London) (11.05.2023)
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Journal Article
A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system
LaFleur, Martin W., Nguyen, Thao H., Coxe, Matthew A., Yates, Kathleen B., Trombley, Justin D., Weiss, Sarah A., Brown, Flavian D., Gillis, Jacob E., Coxe, Daniel J., Doench, John G., Haining, W. Nicholas, Sharpe, Arlene H.
Published in Nature communications (10.04.2019)
Published in Nature communications (10.04.2019)
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Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade
Rashidian, Mohammad, LaFleur, Martin W., Verschoor, Vincent L., Dongre, Anushka, Zhang, Yun, Nguyen, Thao H., Kolifrath, Stephen, Aref, Amir R., Lau, Christie J., Paweletz, Cloud P., Bu, Xia, Freeman, Gordon J., Barrasaf, M. Inmaculad, Weinberg, Robert A., Sharpe, Arlene H., Ploegh, Hidde L.
Published in Proceedings of the National Academy of Sciences - PNAS (20.08.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (20.08.2019)
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Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8 + T Cells
Drijvers, Jefte M, Gillis, Jacob E, Muijlwijk, Tara, Nguyen, Thao H, Gaudiano, Emily F, Harris, Isaac S, LaFleur, Martin W, Ringel, Alison E, Yao, Cong-Hui, Kurmi, Kiran, Juneja, Vikram R, Trombley, Justin D, Haigis, Marcia C, Sharpe, Arlene H
Published in Cancer immunology research (01.02.2021)
Published in Cancer immunology research (01.02.2021)
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Psychosocial and neurocognitive functioning in unipolar and bipolar depression: A 12-month prospective study
Godard, Julie, Baruch, Philippe, Grondin, Simon, Lafleur, Martin F
Published in Psychiatry research (30.03.2012)
Published in Psychiatry research (30.03.2012)
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FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors
Cremasco, Viviana, Astarita, Jillian L, Grauel, Angelo L, Keerthivasan, Shilpa, MacIsaac, Kenzie, Woodruff, Matthew C, Wu, Michael, Spel, Lotte, Santoro, Stephen, Amoozgar, Zohreh, Laszewski, Tyler, Migoni, Sara Cruz, Knoblich, Konstantin, Fletcher, Anne L, LaFleur, Martin, Wucherpfennig, Kai W, Pure, Ellen, Dranoff, Glenn, Carroll, Michael C, Turley, Shannon J
Published in Cancer immunology research (01.12.2018)
Published in Cancer immunology research (01.12.2018)
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Journal Article
Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling
Brown, Flavian D., Sen, Debattama R., LaFleur, Martin W., Godec, Jernej, Lukacs-Kornek, Veronika, Schildberg, Frank A., Kim, Hye-Jung, Yates, Kathleen B., Ricoult, Stéphane J. H., Bi, Kevin, Trombley, Justin D., Kapoor, Varun N., Stanley, Illana A., Cremasco, Viviana, Danial, Nika N., Manning, Brendan D., Sharpe, Arlene H., Haining, W. Nicholas, Turley, Shannon J.
Published in Nature immunology (01.12.2019)
Published in Nature immunology (01.12.2019)
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The Kinesthetic and Visual Imagery Questionnaire (KVIQ) for Assessing Motor Imagery in Persons with Physical Disabilities: A Reliability and Construct Validity Study
Malouin, Francine, Richards, Carol L, Jackson, Philip L, Lafleur, Martin F, Durand, Anne, Doyon, Julien
Published in Journal of neurologic physical therapy (01.03.2007)
Published in Journal of neurologic physical therapy (01.03.2007)
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Journal Article
In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cells
LaFleur, Martin W, D'Andrea, Jasmin M, Patterson, Dillon G, Streeter, Ivy S L, Coxe, Matthew A, Osborn, Jossef F, Milling, Lauren E, Tjokrosurjo, Qin, Gillis, Jacob E, Nguyen, Thao H, Schwartz, Marc A, Hacohen, Nir, Doench, John G, Sharpe, Arlene H
Published in The Journal of immunology (1950) (15.11.2024)
Published in The Journal of immunology (1950) (15.11.2024)
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