Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival
Ramos, Fresnida J, Chen, Steven C, Garelick, Michael G, Dai, Dao-Fu, Liao, Chen-Yu, Schreiber, Katherine H, MacKay, Vivian L, An, Elroy H, Strong, Randy, Ladiges, Warren C, Rabinovitch, Peter S, Kaeberlein, Matt, Kennedy, Brian K
Published in Science translational medicine (25.07.2012)
Published in Science translational medicine (25.07.2012)
Get more information
Journal Article
Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging
DAI, Dao-Fu, SANTANA, Luis F, RABINOVITCH, Peter S, VERMULST, Marc, TOMAZELA, Daniela M, EMOND, Mary J, MACCOSS, Michael J, GOLLAHON, Katherine, MARTIN, George M, LOEB, Lawrence A, LADIGES, Warren C
Published in Circulation (New York, N.Y.) (02.06.2009)
Published in Circulation (New York, N.Y.) (02.06.2009)
Get full text
Journal Article
Measures of Healthspan as Indices of Aging in Mice-A Recommendation
Richardson, Arlan, Fischer, Kathleen E, Speakman, John R, de Cabo, Rafael, Mitchell, Sarah J, Peterson, Charlotte A, Rabinovitch, Peter, Chiao, Ying A, Taffet, George, Miller, Richard A, Rentería, René C, Bower, James, Ingram, Donald K, Ladiges, Warren C, Ikeno, Yuji, Sierra, Felipe, Austad, Steven N
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.04.2016)
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01.04.2016)
Get more information
Journal Article
Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
McElroy, Gregory S., Chakrabarty, Ram P., D’Alessandro, Karis B., Hu, Yuan-Shih, Vasan, Karthik, Tan, Jerica, Stoolman, Joshua S., Weinberg, Samuel E., Steinert, Elizabeth M., Reyfman, Paul A., Singer, Benjamin D., Ladiges, Warren C., Gao, Lin, Lopéz-Barneo, José, Ridge, Karen, Budinger, G. R. Scott, Chandel, Navdeep S.
Published in Scientific reports (25.03.2022)
Published in Scientific reports (25.03.2022)
Get full text
Journal Article
C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension
McQuary, Philip R., Liao, Chen-Yu, Chang, Jessica T., Kumsta, Caroline, She, Xingyu, Davis, Andrew, Chu, Chu-Chiao, Gelino, Sara, Gomez-Amaro, Rafael L., Petrascheck, Michael, Brill, Laurence M., Ladiges, Warren C., Kennedy, Brian K., Hansen, Malene
Published in Cell reports (Cambridge) (08.03.2016)
Published in Cell reports (Cambridge) (08.03.2016)
Get full text
Journal Article
Canagliflozin extends life span in genetically heterogeneous male but not female mice
Miller, Richard A, Harrison, David E, Allison, David B, Bogue, Molly, Debarba, Lucas, Diaz, Vivian, Fernandez, Elizabeth, Galecki, Andrzej, Garvey, W Timothy, Jayarathne, Hashan, Kumar, Navasuja, Javors, Martin A, Ladiges, Warren C, Macchiarini, Francesca, Nelson, James, Reifsnyder, Peter, Rosenthal, Nadia A, Sadagurski, Marianna, Salmon, Adam B, Smith, Jr, Daniel L, Snyder, Jessica M, Lombard, David B, Strong, Randy
Published in JCI insight (05.11.2020)
Published in JCI insight (05.11.2020)
Get full text
Journal Article
The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1
O'Leary, Monique N, Schreiber, Katherine H, Zhang, Yong, Duc, Anne-Cécile E, Rao, Shuyun, Hale, J Scott, Academia, Emmeline C, Shah, Shreya R, Morton, John F, Holstein, Carly A, Martin, Dan B, Kaeberlein, Matt, Ladiges, Warren C, Fink, Pamela J, Mackay, Vivian L, Wiest, David L, Kennedy, Brian K
Published in PLoS genetics (01.08.2013)
Published in PLoS genetics (01.08.2013)
Get full text
Journal Article
Author Correction: Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
McElroy, Gregory S., Chakrabarty, Ram P., D’Alessandro, Karis B., Hu, Yuan-Shih, Vasan, Karthik, Tan, Jerica, Stoolman, Joshua S., Weinberg, Samuel E., Steinert, Elizabeth M., Reyfman, Paul A., Singer, Benjamin D., Ladiges, Warren C., Gao, Lin, Lopéz‑Barneo, José, Ridge, Karen, Budinger, G. R. Scott, Chandel, Navdeep S.
Published in Scientific reports (17.05.2022)
Published in Scientific reports (17.05.2022)
Get full text
Journal Article
Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells
Wiley, Jesse C, Meabon, James S, Frankowski, Harald, Smith, Elise A, Schecterson, Leslayann C, Bothwell, Mark, Ladiges, Warren C
Published in PloS one (09.02.2010)
Published in PloS one (09.02.2010)
Get full text
Journal Article
An immune stress test for resilience to aging: Pneumococcal vaccine response
Oveson, Ryan, Jiang, Zhou, Izhaky, Michali, Sharma, Kavita, Ladiges, Warren C
Published in Aging Pathobiology and Therapeutics (29.09.2020)
Published in Aging Pathobiology and Therapeutics (29.09.2020)
Get full text
Journal Article
Glutamate Cysteine Ligase Modifier Subunit Deficiency and Gender as Determinants of Acetaminophen-Induced Hepatotoxicity in Mice
McConnachie, Lisa A., Mohar, Isaac, Hudson, Francesca N., Ware, Carol B., Ladiges, Warren C., Fernandez, Carolina, Chatterton-Kirchmeier, Sam, White, Collin C., Pierce, Robert H., Kavanagh, Terrance J.
Published in Toxicological sciences (01.10.2007)
Published in Toxicological sciences (01.10.2007)
Get full text
Journal Article
Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations
Zheng, Ruimao, Yang, Linghai, Sikorski, Maria A, Enns, Linda C, Czyzyk, Traci A, Ladiges, Warren C, McKnight, G Stanley
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2013)
Get full text
Journal Article
Disruption of protein kinase A in mice enhances healthy aging
Enns, Linda C, Morton, John F, Treuting, Piper R, Emond, Mary J, Wolf, Norman S, Dai, Dao-Fu, McKnight, G S, Rabinovitch, Peter S, Ladiges, Warren C
Published in PloS one (18.06.2009)
Published in PloS one (18.06.2009)
Get full text
Journal Article
Mutation at the Polymerase Active Site of Mouse DNA Polymerase δ Increases Genomic Instability and Accelerates Tumorigenesis
Venkatesan, Ranga N., Treuting, Piper M., Fuller, Evan D., Goldsby, Robert E., Norwood, Thomas H., Gooley, Ted A., Ladiges, Warren C., Preston, Bradley D., Loeb, Lawrence A.
Published in Molecular and Cellular Biology (01.11.2007)
Published in Molecular and Cellular Biology (01.11.2007)
Get full text
Journal Article
Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency
Ito, Takashi K, Lu, Chenhao, Khan, Jacob, Nguyen, Quy, Huang, Heather Z, Kim, Dayae, Phillips, James, Tan, Jo, Lee, Yenna, Nguyen, Tuyet, Khessib, Samy, Lim, Natalie, Mekvanich, Surapat, Oh, Joshua, Pineda, Victor V, Wang, Weirong, Bitto, Alessandro, An, Jonathan Y, Morton, John F, Setou, Mitsutoshi, Ladiges, Warren C, Kaeberlein, Matt
Published in Frontiers in genetics (01.09.2017)
Published in Frontiers in genetics (01.09.2017)
Get full text
Journal Article
Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice
Frock, Richard L, Chen, Steven C, Da, Dao-Fu, Frett, Ellie, Lau, Carmen, Brown, Christina, Pak, Diana N, Wang, Yuexia, Muchir, Antoine, Worman, Howard J, Santana, Luis F, Ladiges, Warren C, Rabinovitch, Peter S, Kennedy, Brian K
Published in PloS one (15.08.2012)
Published in PloS one (15.08.2012)
Get full text
Journal Article
An aged immune system drives senescence and ageing of solid organs
Yousefzadeh, Matthew J., Flores, Rafael R., Zhu, Yi, Schmiechen, Zoe C., Brooks, Robert W., Trussoni, Christy E., Cui, Yuxiang, Angelini, Luise, Lee, Kyoo-A, McGowan, Sara J., Burrack, Adam L., Wang, Dong, Dong, Qing, Lu, Aiping, Sano, Tokio, O’Kelly, Ryan D., McGuckian, Collin A., Kato, Jonathan I., Bank, Michael P., Wade, Erin A., Pillai, Smitha P. S., Klug, Jenna, Ladiges, Warren C., Burd, Christin E., Lewis, Sara E., LaRusso, Nicholas F., Vo, Nam V., Wang, Yinsheng, Kelley, Eric E., Huard, Johnny, Stromnes, Ingunn M., Robbins, Paul D., Niedernhofer, Laura J.
Published in Nature (London) (03.06.2021)
Published in Nature (London) (03.06.2021)
Get full text
Journal Article