Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology
Macabuag, Natsuko, Esmieu, William, Breccia, Perla, Jarvis, Rebecca, Blackaby, Wesley, Lazari, Ovadia, Urbonas, Liudvikas, Eznarriaga, Maria, Williams, Rachel, Strijbosch, Annelieke, Van de Bospoort, Rhea, Matthews, Kim, Clissold, Cole, Ladduwahetty, Tammy, Vater, Huw, Heaphy, Patrick, Stafford, Douglas G., Wang, Hong-Jun, Mangette, John E., McAllister, George, Beaumont, Vahri, Vogt, Thomas F., Wilkinson, Hilary A., Doherty, Elizabeth M., Dominguez, Celia
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia
Liu, Yiman, Li, Qinglan, Alikarami, Fatemeh, Barrett, Declan R, Mahdavi, Leila, Li, Hangpeng, Tang, Sylvia, Khan, Tanweer A, Michino, Mayako, Hill, Connor, Song, Lele, Yang, Lu, Li, Yuanyuan, Pokharel, Sheela Pangeni, Stamford, Andrew W, Liverton, Nigel, Renzetti, Louis M, Taylor, Simon, Watt, Gillian F, Ladduwahetty, Tammy, Kargman, Stacia, Meinke, Peter T, Foley, Michael A, Shi, Junwei, Li, Haitao, Carroll, Martin, Chen, Chun-Wei, Gardini, Alessandro, Maillard, Ivan, Huggins, David J, Bernt, Kathrin M, Wan, Liling
Published in Cancer discovery (02.11.2022)
Published in Cancer discovery (02.11.2022)
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Journal Article
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington’s Disease
Ladduwahetty, Tammy, Lee, Matthew R., Maillard, Michel C., Cachope, Roger, Todd, Daniel, Barnes, Michael, Beaumont, Vahri, Chauhan, Alka, Gallati, Caroline, Haughan, Alan F., Kempf, Georg, Luckhurst, Christopher A., Matthews, Kim, McAllister, George, Mitchell, Philip, Patel, Hiral, Rose, Mark, Saville-Stones, Elizabeth, Steinbacher, Stefan, Stott, Andrew J., Thatcher, Emma, Tierney, Jason, Urbonas, Liudvikas, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.07.2022)
Published in Journal of medicinal chemistry (28.07.2022)
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Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease
Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Journal Article
ENL/AF9 YEATS의 C-연결된 억제제
SHERBORNE BRADLEY, LADDUWAHETTY TAMMY, KHAN TANWEER A, HUGGINS DAVID JOHN, DEGORCE SEBASTIEN L, VACCA JOSEPH P, LIVERTON NIGEL
Year of Publication 12.04.2024
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Year of Publication 12.04.2024
Patent
신규 화합물
MORPHY RICHARD, MOROGLU MUSTAFA, KULAGOWSKI JAN, RUTTER RICHARD, ROWLEY MICHAEL, LADDUWAHETTY TAMMY, MILLER NEIL, MACLEAN JOHN, TALBOT ERIC
Year of Publication 19.05.2023
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Year of Publication 19.05.2023
Patent
ENL/AF9 YEATS의 억제제
MEINKE PETER, WAN LILING, HUGGINS DAVID, VACCA JOSEPH, LADDUWAHETTY TAMMY, KHAN TANWEER A, STAMFORD ANDREW W, MILLER MICHAEL W, FUKASE YOSHIYUKI, MICHINO MAYAKO, ALLIS C. DAVID, LIVERTON NIGEL
Year of Publication 23.09.2022
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Year of Publication 23.09.2022
Patent
CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model
Cansfield, Andrew D, Ladduwahetty, Tammy, Sunose, Mihiro, Ellard, Katie, Lynch, Rosemary, Newton, Anthea L, Lewis, Ann, Bennett, Gavin, Zinn, Nico, Thomson, Douglas W, Rüger, Anne J, Feutrill, John T, Rausch, Oliver, Watt, Alan P, Bergamini, Giovanna
Published in ACS medicinal chemistry letters (11.08.2016)
Published in ACS medicinal chemistry letters (11.08.2016)
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Journal Article
Non-basic ligands for aminergic GPCRs: The discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders
Ladduwahetty, Tammy, Gilligan, Myra, Humphries, Alexander, Merchant, Kevin J., Fish, Rebecca, McAlister, George, Ivarsson, Magnus, Dominguez, Maria, O’Connor, Desmond, MacLeod, Angus M.
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
A new class of selective, non-basic 5-HT2A receptor antagonists
LADDUWAHETTY, Tammy, BOASE, Amanda L, MITCHINSON, Andrew, QUIN, Caroline, PATEL, Smita, CHAPMAN, Kerry, MACLEOD, Angus M
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
Published in Bioorganic & medicinal chemistry letters (15.06.2006)
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Journal Article
4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia
Fish, L Rebecca, Gilligan, Myra T, Humphries, Alexander C, Ivarsson, Magnus, Ladduwahetty, Tammy, Merchant, Kevin J, O'Connor, Desmond, Patel, Smita, Philipps, Elisabeth, Vargas, Hugo M, Hutson, Peter H, MacLeod, Angus M
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
Published in Bioorganic & medicinal chemistry letters (15.08.2005)
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Journal Article
INHIBITORS OF MPTP
MILLER, Neil, OUVRY, Gilles, ROWLEY, Michael, LADDUWAHETTY, Tammy, KULAGOWSKI, Jan, BOYD, Susan, RUTTER, Richard, THOMSON, Chris
Year of Publication 25.07.2024
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Year of Publication 25.07.2024
Patent
C-LINKED INHIBITORS OF ENL/AF9 YEATS
LIVERTON, Nigel, DEGORCE, Sébastien, LADDUWAHETTY, Tammy, HUGGINS, David, KHAN, Tanweer, VACCA, Joseph, SHERBORNE, Bradley
Year of Publication 30.11.2023
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Year of Publication 30.11.2023
Patent
NOVEL COMPOUNDS
MACLEAN, John, TALBOT, Eric, MILLER, Neil, MORPHY, Richard, KULAGOWSKI, Jan, LADDUWAHETTY, Tammy, RUTTER, Richard
Year of Publication 05.10.2023
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Year of Publication 05.10.2023
Patent
NOVEL COMPOUNDS
MACLEAN, John, TALBOT, Eric, MILLER, Neil, MORPHY, Richard, LADDUWAHETTY, Tammy, KULAGOWSKI, Jan, RUTTER, Richard
Year of Publication 12.07.2023
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Year of Publication 12.07.2023
Patent