Cardiovascular safety of hydroxypropyl-β-cyclodextrin–diclofenac in the management of acute postsurgical pain: a pooled analysis of 2 randomized, double-blind, placebo- and active comparator–controlled phase III clinical trials
Gan, Tong J., MD, MHS, FRCA, Singla, Neil, MD, Daniels, Stephen E., DO, Lacouture, Peter G., PhD, Min, Lauren H., PharmD, Reyes, Christian R.D., MS, Carr, Daniel B., MD
Published in Journal of clinical anesthesia (01.06.2016)
Published in Journal of clinical anesthesia (01.06.2016)
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Single‐Dose and Multiple‐Dose Pharmacokinetics and Dose Proportionality of Intravenous and Intramuscular HPβCD‐Diclofenac (Dyloject) Compared with Other Diclofenac Formulations
Mermelstein, Fred, Hamilton, Douglas A., Wright, Curtis, Lacouture, Peter G., Ramaiya, Atulkumar, Carr, Daniel B.
Published in Pharmacotherapy (01.10.2013)
Published in Pharmacotherapy (01.10.2013)
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A Pooled Analysis Evaluating Renal Safety in Placebo- and Active Comparator-Controlled Phase III Trials of Multiple-Dose Injectable HPβCD-Diclofenac in Subjects with Acute Postoperative Pain
Daniels, Stephen E., Gan, Tong J. (TJ), Hamilton, Douglas A., Singla, Neil, Lacouture, Peter G., Johnson, Olufunmibi, Min, Lauren H., Reyes, Christian R. D., Carr, Daniel B.
Published in Pain medicine (Malden, Mass.) (01.12.2016)
Published in Pain medicine (Malden, Mass.) (01.12.2016)
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Journal Article
A Pooled Analysis Evaluating Renal Safety in Placebo- and Active Comparator-Controlled Phase III Trials of Multiple-Dose Injectable HPβCD-Diclofenac in Subjects with Acute Postoperative Pain
Daniels, Stephen E, Gan, Tong J Tj, Hamilton, Douglas A, Singla, Neil, Lacouture, Peter G, Johnson, Olufunmibi, Min, Lauren H, Reyes, Christian R D, Carr, Daniel B
Published in Pain medicine (Malden, Mass.) (01.12.2016)
Published in Pain medicine (Malden, Mass.) (01.12.2016)
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Journal Article
Postoperative opioid sparing with injectable hydroxypropyl-β-cyclodextrin-diclofenac: pooled analysis of data from two Phase III clinical trials
Gan, Tong J, Singla, Neil, Daniels, Stephen E, Hamilton, Douglas A, Lacouture, Peter G, Reyes, Christian Rd, Carr, Daniel B
Published in Journal of pain research (01.01.2017)
Published in Journal of pain research (01.01.2017)
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Journal Article
Pharmacokinetics of Diclofenac and Hydroxypropyl‐β‐Cyclodextrin (HPβCD) Following Administration of Injectable HPβCD‐Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment
Hamilton, Douglas A., Ernst, Cynthia C., Kramer, William G., Madden, Donna, Lang, Eric, Liao, Edward, Lacouture, Peter G., Ramaiya, Atulkumar, Carr, Daniel B.
Published in Clinical pharmacology in drug development (01.02.2018)
Published in Clinical pharmacology in drug development (01.02.2018)
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Journal Article
Effects of Injectable HPβCD-Diclofenac on the Human Delayed Rectifier Potassium Channel Current In Vitro and on Proarrhythmic QTc In Vivo
Carr, Daniel B., MD, McDonnell Moorehead, Tara, BA, Bouchard, Annie, MSc, Sprenger, Craig R., MD, Hamilton, Douglas A., MBA, Lang, Eric, MD, Madden, Donna, MS, Lacouture, Peter G., PhD, Wright, Curtis, MD, MPH
Published in Clinical therapeutics (01.05.2013)
Published in Clinical therapeutics (01.05.2013)
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Journal Article
Safety of a Novel Parenteral Formulation of Diclofenac after Major Orthopedic or Abdominal/Pelvic Surgery in a Population Including Anticoagulated, Elderly or Renally Insufficient Patients: An Open‐Label, Multiday, Repeated Dose Clinical Trial
Chelly, Jacques E., Singla, Sonia K., Melson, Timothy I., Lacouture, Peter G., Paadre, Susan, Carr, Daniel B.
Published in Pain medicine (Malden, Mass.) (01.05.2013)
Published in Pain medicine (Malden, Mass.) (01.05.2013)
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Journal Article
The dose response and effects of dexamethasone on bupivacaine microcapsules for intercostal blockade (T9 to T11) in healthy volunteers
KOPACZ, Dan J, LACOUTURE, Peter G, DANLIN WU, NANDY, Partha, SWANTON, Ruth, LANDAU, Craig
Published in Anesthesia and analgesia (01.02.2003)
Published in Anesthesia and analgesia (01.02.2003)
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A Multicenter, Open-Label, Exploratory Dose-Ranging Trial of Intranasal Hydromorphone for Managing Acute Pain from Traumatic Injury
Wermeling, Daniel P, Clinch, Thomas, Rudy, Anita C, Dreitlein, David, Suner, Selim, Lacouture, Peter G
Published in The journal of pain (2010)
Published in The journal of pain (2010)
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A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin
Goldwater, Ronald, Kramer, William G, Hamilton, Douglas A, Lang, Eric, Wang, Jianyuan, Madden, Donna E, Lacouture, Peter G, Ramaiya, Atulkumar, Carr, Daniel B
Published in Clinical pharmacology: advances and applications (01.01.2016)
Published in Clinical pharmacology: advances and applications (01.01.2016)
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A Model to Evaluate the Pharmacokinetic and Pharmacodynamic Variables of Extended-Release Products Using In Vivo Tissue Microdialysis in Humans: Bupivacaine-Loaded Microcapsules
Kopacz, Dan J, Bernards, Christopher M, Allen, Hugh W, Landau, Craig, Nandy, Partha, Wu, Danlin, Lacouture, Peter G
Published in Anesthesia and analgesia (01.07.2003)
Published in Anesthesia and analgesia (01.07.2003)
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Bupivacaine in microcapsules prolongs analgesia after subcutaneous infiltration in humans: A dose-finding study
PEDERSEN, Juri L, LILLESØ, Jesper, HAMMER, Niels A, WERNER, Mads U, HOLTE, Kathrine, LACOUTURE, Peter G, KEHLET, Henrik
Published in Anesthesia and analgesia (01.09.2004)
Published in Anesthesia and analgesia (01.09.2004)
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Efficacy and safety of controlled-release versus immediate-release oxycodone: randomized, double-blind evaluation in patients with chronic back pain
Hale, M E, Fleischmann, R, Salzman, R, Wild, J, Iwan, T, Swanton, R E, Kaiko, R F, Lacouture, P G
Published in The Clinical journal of pain (01.09.1999)
Published in The Clinical journal of pain (01.09.1999)
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Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers
Gale, Donna Donigi, Landells, Linda J., Spina, Domenico, Miller, Alan J., Smith, Kate, Nichols, Terry, Rotshteyn, Yakov, Tonelli, Alfred, Lacouture, Peter, Burch, Ronald M., Page, Clive P., O'Connor, Brian J.
Published in British journal of clinical pharmacology (01.11.2002)
Published in British journal of clinical pharmacology (01.11.2002)
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Journal Article
The Dose Response and Effects of Dexamethasone on Bupivacaine Microcapsules for Intercostal Blockade (T9 to T11) in Healthy Volunteers
Kopacz, Dan J., Lacouture, Peter G., Wu, Danlin, Nandy, Partha, Swanton, Ruth, Landau, Craig
Published in Anesthesia and analgesia (01.02.2003)
Published in Anesthesia and analgesia (01.02.2003)
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