In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells
Soucie, Erinn, Hanssens, Katia, Mercher, Thomas, Georgin-Lavialle, Sophie, Damaj, Gandhi, Livideanu, Cristina, Chandesris, Maria Olivia, Acin, Yolène, Létard, Sebastien, de Sepulveda, Paulo, Hermine, Olivier, Bernard, Olivier A., Dubreuil, Patrice
Published in Blood (06.12.2012)
Published in Blood (06.12.2012)
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Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU‐285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies
Weisberg, Ellen, Meng, Chengcheng, Case, Abigail E., Sattler, Martin, Tiv, Hong L., Gokhale, Prafulla C., Buhrlage, Sara J., Liu, Xiaoxi, Yang, Jing, Wang, Jinhua, Gray, Nathanael, Stone, Richard M., Adamia, Sophia, Dubreuil, Patrice, Letard, Sebastien, Griffin, James D.
Published in British journal of haematology (01.11.2019)
Published in British journal of haematology (01.11.2019)
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Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells
Aouar, Besma, Kovarova, Denisa, Letard, Sebastien, Font-Haro, Albert, Florentin, Jonathan, Weber, Jan, Durantel, David, Chaperot, Laurence, Plumas, Joel, Trejbalova, Katerina, Hejnar, Jiri, Nunès, Jacques A, Olive, Daniel, Dubreuil, Patrice, Hirsch, Ivan, Stranska, Ruzena
Published in PloS one (03.06.2016)
Published in PloS one (03.06.2016)
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Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology
Hammam, Kahina, Saez-Ayala, Magali, Rebuffet, Etienne, Gros, Laurent, Lopez, Sophie, Hajem, Berengere, Humbert, Martine, Baudelet, Emilie, Audebert, Stephane, Betzi, Stephane, Lugari, Adrien, Combes, Sebastien, Letard, Sebastien, Casteran, Nathalie, Mansfield, Colin, Moussy, Alain, De Sepulveda, Paulo, Morelli, Xavier, Dubreuil, Patrice
Published in Nature communications (10.11.2017)
Published in Nature communications (10.11.2017)
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Pediatric mastocytosis–associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations
Yang, Ying, Létard, Sébastien, Borge, Laurence, Chaix, Amandine, Hanssens, Katia, Lopez, Sophie, Vita, Marina, Finetti, Pascal, Birnbaum, Daniel, Bertucci, François, Gomez, Sophie, de Sepulveda, Paulo, Dubreuil, Patrice
Published in Blood (19.08.2010)
Published in Blood (19.08.2010)
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The Recurrent Liver MAN2A1-FER Oncoprotein Lacks Kinase Activity: Implications for the Use of Tyrosine Kinase Inhibitors
Desaunay, Mathieu, Voisset, Edwige, Letard, Sebastien, Roche, Philippe, De Sepulveda, Paulo
Published in Cellular and molecular gastroenterology and hepatology (2024)
Published in Cellular and molecular gastroenterology and hepatology (2024)
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Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and their effects in multiple in-vitro models
Zorzan, Eleonora, Da Ros, Silvia, Musetti, Caterina, Shahidian, Lara Zorro, Coelho, Nuno Filipe Ramos, Bonsembiante, Federico, Létard, Sébastien, Gelain, Maria Elena, Palumbo, Manlio, Dubreuil, Patrice, Giantin, Mery, Sissi, Claudia, Dacasto, Mauro
Published in Oncotarget (19.04.2016)
Published in Oncotarget (19.04.2016)
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Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation
Zappulla, Jacques P, Dubreuil, Patrice, Desbois, Sabine, Létard, Sébastien, Hamouda, Nadine Ben, Daëron, Marc, Delsol, Georges, Arock, Michel, Liblau, Roland S
Published in The Journal of experimental medicine (19.12.2005)
Published in The Journal of experimental medicine (19.12.2005)
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TET2 regulates immune tolerance in chronically activated mast cells
Rigo, Riccardo, Chelbi, Rabie, Agopian, Julie, Letard, Sebastien, Griffon, Aurélien, Ghamlouch, Hussein, Vernerey, Julien, Ladopoulos, Vasileios, Voisset, Edwige, De Sepulveda, Paulo, Guittard, Geoffrey, Nunès, Jacques A, Bidaut, Ghislain, Göttgens, Berthold, Weber, Michael, Bernard, Olivier A, Dubreuil, Patrice, Soucie, Erinn
Published in JCI insight (08.04.2022)
Published in JCI insight (08.04.2022)
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Familial hematological malignancies: new IDH2 mutation
Hamadou, Walid-Sabri, Bourdon, Violaine, Létard, Sébastien, Brenet, Fabienne, Laarif, Sofien, Besbes, Sawsen, Paci, Angelo, David, Muriel, Penard-Lacronique, Virginie, Youssef, Yosra Ben, Laatiri, Mohamed-Adnène, Eisinger, François, Mari, Véronique, Gesta, Paul, Dreyfus, Hélène, Bonadona, Valérie, Dugast, Catherine, Zattara, Hélène, Faivre, Laurence, Noguchi, Testsuro, Khélif, Abderrahim, Salem, Chaker Ben, Dubreuil, Patrice, Sobol, Hagay, Soua, Zohra
Published in Annals of hematology (01.12.2016)
Published in Annals of hematology (01.12.2016)
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Gain-of-Function Mutations in the Extracellular Domain of KIT Are Common in Canine Mast Cell Tumors
Letard, Sébastien, Yang, Ying, Hanssens, Katia, Palmérini, Fabienne, Leventhal, Phillip S, Guéry, Stéphanie, Moussy, Alain, Kinet, Jean-Pierre, Hermine, Olivier, Dubreuil, Patrice
Published in Molecular cancer research (01.07.2008)
Published in Molecular cancer research (01.07.2008)
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Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
Dubreuil, Patrice, Letard, Sébastien, Ciufolini, Marco, Gros, Laurent, Humbert, Martine, Castéran, Nathalie, Borge, Laurence, Hajem, Bérengère, Lermet, Anne, Sippl, Wolfgang, Voisset, Edwige, Arock, Michel, Auclair, Christian, Leventhal, Phillip S, Mansfield, Colin D, Moussy, Alain, Hermine, Olivier
Published in PloS one (30.09.2009)
Published in PloS one (30.09.2009)
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Wide Range Sequencing of FLT3 Reveals a New Activating Mutation Associated with a Decreased Sensitivity to Tyrosine Kinase Inhibitors in Acute Myeloid Leukaemia
Garrigue, Philippe, Prebet, Thomas, Létard, Sébastien, Hanssens, Katia, Sippl, Wolfgang, Lermet, Anne, Vey, Norbert, Borg, Jean Paul, Dubreuil, Patrice
Published in Blood (20.11.2009)
Published in Blood (20.11.2009)
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Identification of new aminoacid amides containing the imidazo[2,1- b]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling
Furlan, Alessandro, Colombo, Francesco, Kover, Andrea, Issaly, Nathalie, Tintori, Cristina, Angeli, Lucilla, Leroux, Vincent, Letard, Sébastien, Amat, Mercedes, Asses, Yasmine, Maigret, Bernard, Dubreuil, Patrice, Botta, Maurizio, Dono, Rosanna, Bosch, Joan, Piccolo, Oreste, Passarella, Daniele, Maina, Flavio
Published in European journal of medicinal chemistry (2012)
Published in European journal of medicinal chemistry (2012)
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Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model
Humbert, Martine, Castéran, Nathalie, Letard, Sébastien, Hanssens, Katia, Iovanna, Juan, Finetti, Pascal, Bertucci, François, Bader, Thomas, Mansfield, Colin D, Moussy, Alain, Hermine, Olivier, Dubreuil, Patrice
Published in PloS one (04.03.2010)
Published in PloS one (04.03.2010)
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Mast cell leukemia: identification of a new c-Kit mutation, dup(501-502), and response to masitinib, a c-Kit tyrosine kinase inhibitor
Georgin-Lavialle, Sophie, Lhermitte, Ludovic, Suarez, Felipe, Yang, Ying, Letard, Sébastien, Hanssens, Katia, Feger, Frédéric, Renand, Amédée, Brouze, Chantal, Canioni, Danielle, Asnafi, Vahid, Chandesris, Marie-Olivia, Aouba, Achille, Gineste, Paul, Macintyre, Elizabeth, Mansfield, Colin D., Moussy, Alain, Lepelletier, Yves, Dubreuil, Patrice, Hermine, Olivier
Published in European journal of haematology (01.07.2012)
Published in European journal of haematology (01.07.2012)
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Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells
Gabillot-Carré, Marion, Lepelletier, Yves, Humbert, Martine, de Sepuvelda, Paulo, Hamouda, Nadine Ben, Zappulla, Jean Pierre, Liblau, Roland, Ribadeau-Dumas, Antoine, Machavoine, François, Letard, Sébastien, Baude, Cédric, Hermant, Aurélie, Yang, Ying, Vargaftig, Jacques, Bodemer, Christine, Morelon, Emmanuel, Lortholary, Olivier, Recher, Christian, Laurent, Guy, Dy, Michel, Arock, Michel, Dubreuil, Patrice, Hermine, Olivier
Published in Blood (01.08.2006)
Published in Blood (01.08.2006)
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Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU-285 on oncogenic mutants of KIT and FLT3 in hematologic malignancies: Mutant KIT and FLT3 response to Tyrosine Kinase Inhibitors
Weisberg, Ellen, Meng, Chengcheng, Case, Abigail, Sattler, Martin, Tiv, Hong L., Gokhale, Prafulla C., Buhrlage, Sara, Liu, Xiaoxi, Yang, Jing, Wang, Jinhua, Gray, Nathanael, Stone, Richard, Adamia, Sophia, Dubreuil, Patrice, Letard, Sebastien, Griffin, James D.
Published in British journal of haematology (15.07.2019)
Published in British journal of haematology (15.07.2019)
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Signal transduction by several KIT juxtamembrane domain mutations
CASTERAN, Nathalie, DE SEPULVEDA, Paulo, BESLU, Nathalie, AOUBALA, Mustapha, LETARD, Sébastien, LECOCQ, Eric, ROTTAPEL, Robert, DUBREUIL, Patrice
Published in Oncogene (24.07.2003)
Published in Oncogene (24.07.2003)
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