Cryo-EM structure of a human spliceosome activated for step 2 of splicing
Bertram, Karl, Agafonov, Dmitry E., Liu, Wen-Ti, Dybkov, Olexandr, Will, Cindy L., Hartmuth, Klaus, Urlaub, Henning, Kastner, Berthold, Stark, Holger, Lührmann, Reinhard
Published in Nature (London) (16.02.2017)
Published in Nature (London) (16.02.2017)
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Journal Article
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation
Bertram, Karl, Agafonov, Dmitry E., Dybkov, Olexandr, Haselbach, David, Leelaram, Majety N., Will, Cindy L., Urlaub, Henning, Kastner, Berthold, Lührmann, Reinhard, Stark, Holger
Published in Cell (10.08.2017)
Published in Cell (10.08.2017)
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Journal Article
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion
Girard, Cyrille, Will, Cindy L., Peng, Jianhe, Makarov, Evgeny M., Kastner, Berthold, Lemm, Ira, Urlaub, Henning, Hartmuth, Klaus, Lührmann, Reinhard
Published in Nature communications (07.08.2012)
Published in Nature communications (07.08.2012)
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Journal Article
Isolation of an active step I spliceosome and composition of its RNP core
Bessonov, Sergey, Lührmann, Reinhard, Will, Cindy L, Urlaub, Henning, Anokhina, Maria
Published in Nature (17.04.2008)
Published in Nature (17.04.2008)
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Journal Article
Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations
Cretu, Constantin, Schmitzová, Jana, Ponce-Salvatierra, Almudena, Dybkov, Olexandr, De Laurentiis, Evelina I., Sharma, Kundan, Will, Cindy L., Urlaub, Henning, Lührmann, Reinhard, Pena, Vladimir
Published in Molecular cell (20.10.2016)
Published in Molecular cell (20.10.2016)
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Journal Article
Structural insights into the mechanism of the DEAH-box RNA helicase Prp43
Tauchert, Marcel J, Fourmann, Jean-Baptiste, Lührmann, Reinhard, Ficner, Ralf
Published in eLife (16.01.2017)
Published in eLife (16.01.2017)
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Journal Article
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds
Cretu, Constantin, Agrawal, Anant A., Cook, Andrew, Will, Cindy L., Fekkes, Peter, Smith, Peter G., Lührmann, Reinhard, Larsen, Nicholas, Buonamici, Silvia, Pena, Vladimir
Published in Molecular cell (19.04.2018)
Published in Molecular cell (19.04.2018)
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Journal Article
Dynamic Protein-Protein Interaction Wiring of the Human Spliceosome
Hegele, Anna, Kamburov, Atanas, Grossmann, Arndt, Sourlis, Chrysovalantis, Wowro, Sylvia, Weimann, Mareike, Will, Cindy L., Pena, Vlad, Lührmann, Reinhard, Stelzl, Ulrich
Published in Molecular cell (24.02.2012)
Published in Molecular cell (24.02.2012)
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Journal Article
Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation
Townsend, Cole, Leelaram, Majety N, Agafonov, Dmitry E, Dybkov, Olexandr, Will, Cindy L, Bertram, Karl, Urlaub, Henning, Kastner, Berthold, Stark, Holger, Lührmann, Reinhard
Published in Science (American Association for the Advancement of Science) (18.12.2020)
Published in Science (American Association for the Advancement of Science) (18.12.2020)
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Journal Article
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa
Buskin, Adriana, Zhu, Lili, Chichagova, Valeria, Basu, Basudha, Mozaffari-Jovin, Sina, Dolan, David, Droop, Alastair, Collin, Joseph, Bronstein, Revital, Mehrotra, Sudeep, Farkas, Michael, Hilgen, Gerrit, White, Kathryn, Pan, Kuan-Ting, Treumann, Achim, Hallam, Dean, Bialas, Katarzyna, Chung, Git, Mellough, Carla, Ding, Yuchun, Krasnogor, Natalio, Przyborski, Stefan, Zwolinski, Simon, Al-Aama, Jumana, Alharthi, Sameer, Xu, Yaobo, Wheway, Gabrielle, Szymanska, Katarzyna, McKibbin, Martin, Inglehearn, Chris F., Elliott, David J., Lindsay, Susan, Ali, Robin R., Steel, David H., Armstrong, Lyle, Sernagor, Evelyne, Urlaub, Henning, Pierce, Eric, Lührmann, Reinhard, Grellscheid, Sushma-Nagaraja, Johnson, Colin A., Lako, Majlinda
Published in Nature communications (12.10.2018)
Published in Nature communications (12.10.2018)
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Journal Article
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly
Jagtap, Pravin Kumar Ankush, Kubelka, Tomáš, Soni, Komal, Will, Cindy L., Garg, Divita, Sippel, Claudia, Kapp, Tobias G., Potukuchi, Harish Kumar, Schorpp, Kenji, Hadian, Kamyar, Kessler, Horst, Lührmann, Reinhard, Hausch, Felix, Bach, Thorsten, Sattler, Michael
Published in Nature communications (06.11.2020)
Published in Nature communications (06.11.2020)
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Journal Article
The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes
De, Inessa, Bessonov, Sergey, Hofele, Romina, dos Santos, Karine, Will, Cindy L, Urlaub, Henning, Lührmann, Reinhard, Pena, Vladimir
Published in Nature structural & molecular biology (01.02.2015)
Published in Nature structural & molecular biology (01.02.2015)
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Journal Article
The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction
Fourmann, Jean-Baptiste, Dybkov, Olexandr, Agafonov, Dmitry E, Tauchert, Marcel J, Urlaub, Henning, Ficner, Ralf, Fabrizio, Patrizia, Lührmann, Reinhard
Published in eLife (26.04.2016)
Published in eLife (26.04.2016)
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Journal Article
Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes
Herold, Nadine, Will, Cindy L, Wolf, Elmar, Kastner, Berthold, Urlaub, Henning, Lührmann, Reinhard
Published in Molecular and Cellular Biology (01.01.2009)
Published in Molecular and Cellular Biology (01.01.2009)
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Journal Article
Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count
Schmidt, Carla, Grønborg, Mads, Deckert, Jochen, Bessonov, Sergey, Conrad, Thomas, Lührmann, Reinhard, Urlaub, Henning
Published in RNA (Cambridge) (01.03.2014)
Published in RNA (Cambridge) (01.03.2014)
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Journal Article
Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes
Schneider, Cornelius, Agafonov, Dmitry E, Schmitzová, Jana, Hartmuth, Klaus, Fabrizio, Patrizia, Lührmann, Reinhard
Published in PLoS genetics (01.09.2015)
Published in PLoS genetics (01.09.2015)
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Journal Article
Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions
Deckert, Jochen, Hartmuth, Klaus, Boehringer, Daniel, Behzadnia, Nastaran, Will, Cindy L., Kastner, Berthold, Stark, Holger, Urlaub, Henning, Lührmann, Reinhard
Published in Molecular and Cellular Biology (01.07.2006)
Published in Molecular and Cellular Biology (01.07.2006)
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Journal Article
A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing
Liu, Sunbin, Mozaffari-Jovin, Sina, Wollenhaupt, Jan, Santos, Karine F, Theuser, Matthias, Dunin-Horkawicz, Stanislaw, Fabrizio, Patrizia, Bujnicki, Janusz M, Lührmann, Reinhard, Wahl, Markus C
Published in eLife (10.07.2015)
Published in eLife (10.07.2015)
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Journal Article