Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1
Thomas, Suzanne, Kuncheria, Linta, Roulstone, Victoria, Kyula, Joan N, Mansfield, David, Bommareddy, Praveen K, Smith, Henry, Kaufman, Howard L, Harrington, Kevin J, Coffin, Robert S
Published in Journal for immunotherapy of cancer (10.08.2019)
Published in Journal for immunotherapy of cancer (10.08.2019)
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Journal Article
Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status
Hafsi, Hind, Dillon, Magnus T, Barker, Holly E, Kyula, Joan N, Schick, Ulrike, Paget, James T, Smith, Henry G, Pedersen, Malin, McLaughlin, Martin, Harrington, Kevin J
Published in Frontiers in oncology (13.07.2018)
Published in Frontiers in oncology (13.07.2018)
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Journal Article
Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy
Patin, Emmanuel C, Nenclares, Pablo, Chan Wah Hak, Charleen, Dillon, Magnus T, Patrikeev, Anton, McLaughlin, Martin, Grove, Lorna, Foo, Shane, Soliman, Heba, Barata, Joao P, Marsden, Joanna, Baldock, Holly, Gkantalis, Jim, Roulstone, Victoria, Kyula, Joan, Burley, Amy, Hubbard, Lisa, Pedersen, Malin, Smith, Simon A, Clancy-Thompson, Eleanor, Melcher, Alan A, Ono, Masahiro, Rullan, Antonio, Harrington, Kevin J
Published in Nature communications (13.08.2024)
Published in Nature communications (13.08.2024)
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Journal Article
Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer
KYULA, Joan N, VAN SCHAEYBROECK, Sandra, DOHERTY, Joanne, FENNING, Catherine S, LONGLEY, Daniel B, JOHNSTON, Patrick G
Published in Clinical cancer research (01.07.2010)
Published in Clinical cancer research (01.07.2010)
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Journal Article
RIPK1‐mediated immunogenic cell death promotes anti‐tumour immunity against soft‐tissue sarcoma
Smith, Henry G, Jamal, Kunzah, Dayal, Jasbani HS, Tenev, Tencho, Kyula‐Currie, Joan, Guppy, Naomi, Gazinska, Patrycja, Roulstone, Victoria, Liccardi, Gianmaria, Davies, Emma, Roxanis, Ioannis, Melcher, Alan A, Hayes, Andrew J, Inman, Gareth J, Harrington, Kevin J, Meier, Pascal
Published in EMBO molecular medicine (08.06.2020)
Published in EMBO molecular medicine (08.06.2020)
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Journal Article
Harnessing radiotherapy-induced NK-cell activity by combining DNA damage–response inhibition and immune checkpoint blockade
Patin, Emmanuel C, Dillon, Magnus T, Nenclares, Pablo, Grove, Lorna, Soliman, Heba, Leslie, Isla, Northcote, Davina, Bozhanova, Galabina, Crespo-Rodriguez, Eva, Baldock, Holly, Whittock, Harriet, Baker, Gabriella, Kyula, Joan, Guevara, Jeane, Melcher, Alan A, Harper, James, Ghadially, Hormas, Smith, Simon, Pedersen, Malin, McLaughlin, Martin, Harrington, Kevin J
Published in Journal for immunotherapy of cancer (01.03.2022)
Published in Journal for immunotherapy of cancer (01.03.2022)
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Journal Article
Targeted Radiosensitization by the Chk1 Inhibitor SAR-020106
Borst, Gerben R., MD, PhD, McLaughlin, Martin, PhD, Kyula, Joan N., PhD, Neijenhuis, Sari, PhD, Khan, Aadil, M.R.C.S, Good, James, PhD, Zaidi, Shane, PhD, Powell, Ned G., PhD, Meier, Pascal, PhD, Collins, Ian, PhD, Garrett, Michelle D., PhD, Verheij, Marcel, MD, PhD, Harrington, Kevin J., MD, PhD
Published in International journal of radiation oncology, biology, physics (15.03.2013)
Published in International journal of radiation oncology, biology, physics (15.03.2013)
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Journal Article
Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients
Adair, Robert A, Roulstone, Victoria, Scott, Karen J, Morgan, Ruth, Nuovo, Gerard J, Fuller, Martin, Beirne, Deborah, West, Emma J, Jennings, Victoria A, Rose, Ailsa, Kyula, Joan, Fraser, Sheila, Dave, Rajiv, Anthoney, David A, Merrick, Alison, Prestwich, Robin, Aldouri, Amer, Donnelly, Oliver, Pandha, Hardev, Coffey, Matt, Selby, Peter, Vile, Richard, Toogood, Giles, Harrington, Kevin, Melcher, Alan A
Published in Science translational medicine (13.06.2012)
Published in Science translational medicine (13.06.2012)
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HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation
McLaughlin, Martin, Barker, Holly E, Khan, Aadil A, Pedersen, Malin, Dillon, Magnus, Mansfield, David C, Patel, Radhika, Kyula, Joan N, Bhide, Shreerang A, Newbold, Kate L, Nutting, Christopher M, Harrington, Kevin J
Published in BMC cancer (31.01.2017)
Published in BMC cancer (31.01.2017)
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Journal Article
The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism
McLaughlin, Martin, Pedersen, Malin, Roulstone, Victoria, Bergerhoff, Katharina F., Smith, Henry G., Whittock, Harriet, Kyula, Joan N., Dillon, Magnus T., Pandha, Hardev S., Vile, Richard, Melcher, Alan A., Harrington, Kevin J.
Published in Molecular therapy. Oncolytics (27.03.2020)
Published in Molecular therapy. Oncolytics (27.03.2020)
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Journal Article
Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues
Khan, Aadil A, Paget, James T, McLaughlin, Martin, Kyula, Joan N, Wilkinson, Michelle J, Pencavel, Timothy, Mansfield, David, Roulstone, Victoria, Seth, Rohit, Halle, Martin, Somaiah, Navita, Boult, Jessica K R, Robinson, Simon P, Pandha, Hardev S, Vile, Richard G, Melcher, Alan A, Harris, Paul A, Harrington, Kevin J
Published in Science translational medicine (24.01.2018)
Published in Science translational medicine (24.01.2018)
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Journal Article
An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation
Patel, Radhika, Barker, Holly E, Kyula, Joan, McLaughlin, Martin, Dillon, Magnus T, Schick, Ulrike, Hafsi, Hind, Thompson, Alan, Khoo, Vincent, Harrington, Kevin, Zaidi, Shane
Published in Radiotherapy and oncology (01.03.2017)
Published in Radiotherapy and oncology (01.03.2017)
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Journal Article
Oncogenic Kras Promotes Chemotherapy-Induced Growth Factor Shedding via ADAM17
VAN SCHAEYBROECK, Sandra, KYULA, Joan N, FENTON, Audrey, FENNING, Catherine S, SASAZUKI, Takehiko, SHIRASAWA, Senji, LONGLEY, Daniel B, JOHNSTON, Patrick G
Published in Cancer research (Chicago, Ill.) (01.02.2011)
Published in Cancer research (Chicago, Ill.) (01.02.2011)
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Journal Article
Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling
McEntee, Gráinne, Kyula, Joan N, Mansfield, David, Smith, Henry, Wilkinson, Michelle, Gregory, Claire, Roulstone, Victoria, Coffey, Matt, Harrington, Kevin J
Published in Oncotarget (26.07.2016)
Published in Oncotarget (26.07.2016)
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Journal Article
Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling
Armstrong, Edward, Chiu, Matthew K L, Foo, Shane, Appleton, Lizzie, Nenclares, Pablo, Patrikeev, Anton, Mohan, Nitya, Mclaughlin, Martin, Bozhanova, Galabina, Hoebart, Julia, Roulstone, Victoria, Patin, Emmanuel, Pedersen, Malin, Kyula, Joan, Ono, Masahiro, Errington-Mais, Fiona, Bell, John, Harrington, Kevin J, Melcher, Alan, Jennings, Victoria
Published in Journal for immunotherapy of cancer (25.07.2024)
Published in Journal for immunotherapy of cancer (25.07.2024)
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Journal Article
CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma
Bozhanova, Galabina, Hassan, Jehanne, Appleton, Lizzie, Jennings, Victoria, Foo, Shane, McLaughlin, Martin, Chan Wah Hak, Charleen Ml, Patin, Emmanuel C, Crespo-Rodriguez, Eva, Baker, Gabby, Armstrong, Edward, Chiu, Matthew, Pandha, Hardev, Samson, Adel, Roulstone, Victoria, Kyula, Joan, Vile, Richard, Errington-Mais, Fiona, Pedersen, Malin, Harrington, Kevin, Ono, Masahiro, Melcher, Alan
Published in Journal for immunotherapy of cancer (01.03.2022)
Published in Journal for immunotherapy of cancer (01.03.2022)
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Journal Article
Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway
Twigger, Katie, Roulstone, Victoria, Kyula, Joan, Karapanagiotou, Eleni M, Syrigos, Konstantinos N, Morgan, Richard, White, Christine, Bhide, Shreerang, Nuovo, Gerard, Coffey, Matt, Thompson, Brad, Jebar, Adel, Errington, Fiona, Melcher, Alan A, Vile, Richard G, Pandha, Hardev S, Harrington, Kevin J
Published in BMC cancer (24.08.2012)
Published in BMC cancer (24.08.2012)
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Journal Article
Adenovirally delivered enzyme prodrug therapy with herpes simplex virus-thymidine kinase in composite tissue free flaps shows therapeutic efficacy in rat models of glioma
Seth, Rohit, Khan, Aadil A, Pencavel, Timothy D, Wilkinson, Michelle J, Kyula, Joan N, Simpson, Guy, Pandha, Hardev, Melcher, Alan, Vile, Richard, Harris, Paul A, Harrington, Kevin J
Published in Plastic and reconstructive surgery (1963) (01.02.2015)
Published in Plastic and reconstructive surgery (1963) (01.02.2015)
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Chemotherapy-induced epidermal growth factor receptor activation determines response to combined gefitinib/chemotherapy treatment in non–small cell lung cancer cells
Van Schaeybroeck, Sandra, Kyula, Joan, Kelly, Donal M, Karaiskou-McCaul, Anthi, Stokesberry, Susan A, Van Cutsem, Eric, Longley, Daniel B, Johnston, Patrick G
Published in Molecular cancer therapeutics (01.05.2006)
Published in Molecular cancer therapeutics (01.05.2006)
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