The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity
Serrano, Joan, Boyd, Jordan, Brown, Ian S., Mason, Carter, Smith, Kathleen R., Karolyi, Katalin, Maurya, Santosh K., Meshram, Nishita N., Serna, Vanida, Link, Grace M., Gardell, Stephen J., Kyriazis, George A.
Published in Nature communications (08.06.2024)
Published in Nature communications (08.06.2024)
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Journal Article
Sweet Taste Receptors Regulate Basal Insulin Secretion and Contribute to Compensatory Insulin Hypersecretion During the Development of Diabetes in Male Mice
Kyriazis, George A, Smith, Kathleen R, Tyrberg, Björn, Hussain, Tania, Pratley, Richard E
Published in Endocrinology (Philadelphia) (01.06.2014)
Published in Endocrinology (Philadelphia) (01.06.2014)
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High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice
Serrano, Joan, Smith, Kathleen R, Crouch, Audra L, Sharma, Vandana, Yi, Fanchao, Vargova, Veronika, LaMoia, Traci E, Dupont, Lydia M, Serna, Vanida, Tang, Fenfen, Gomes-Dias, Laisa, Blakeslee, Joshua J, Hatzakis, Emmanuel, Peterson, Scott N, Anderson, Matthew, Pratley, Richard E, Kyriazis, George A
Published in Microbiome (12.01.2021)
Published in Microbiome (12.01.2021)
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Journal Article
Receptor Channel TRPC6 Is a Key Mediator of Notch-Driven Glioblastoma Growth and Invasiveness
CHIGURUPATI, Srinivasulu, VENKATARAMAN, Rajarajeswari, LATHIA, Justin D, RICH, Jeremy N, CHAN, Sic L, BARRERA, Daniel, NAGANATHAN, Anusha, MADAN, Meenu, PAUL, Leena, PATTISAPU, Jogi V, KYRIAZIS, George A, SUGAYA, Kiminobu, BUSHNEV, Sergey
Published in Cancer research (Chicago, Ill.) (2010)
Published in Cancer research (Chicago, Ill.) (2010)
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Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study
Karimian Azari, Elnaz, Smith, Kathleen R, Yi, Fanchao, Osborne, Timothy F, Bizzotto, Roberto, Mari, Andrea, Pratley, Richard E, Kyriazis, George A
Published in The American journal of clinical nutrition (01.04.2017)
Published in The American journal of clinical nutrition (01.04.2017)
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Journal Article
The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans
Serrano, Joan, Seflova, Jaroslava, Park, Jihye, Pribadi, Marsha, Sanematsu, Keisuke, Shigemura, Noriatsu, Serna, Vanida, Yi, Fanchao, Mari, Andrea, Procko, Erik, Pratley, Richard E., Robia, Seth L., Kyriazis, George A.
Published in Molecular metabolism (Germany) (01.12.2021)
Published in Molecular metabolism (Germany) (01.12.2021)
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Journal Article
T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways
Smith, Kathleen, Karimian Azari, Elnaz, LaMoia, Traci E., Hussain, Tania, Vargova, Veronika, Karolyi, Katalin, Veldhuis, Paula P., Arnoletti, Juan Pablo, de la Fuente, Sebastian G., Pratley, Richard E., Osborne, Timothy F., Kyriazis, George A.
Published in Molecular metabolism (Germany) (01.11.2018)
Published in Molecular metabolism (Germany) (01.11.2018)
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Journal Article
The Ile191Val Variant of the TAS1R2 Subunit of Sweet Taste Receptors Is Associated With Reduced HbA1c in a Human Cohort With Variable Levels of Glucose Homeostasis
Serrano, Joan, Yi, Fanchao, Smith, Joshua, Pratley, Richard E., Kyriazis, George A.
Published in Frontiers in nutrition (Lausanne) (19.05.2022)
Published in Frontiers in nutrition (Lausanne) (19.05.2022)
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Cardiac-derived TGF-β1 confers resistance to diet-induced obesity through the regulation of adipocyte size and function
Longenecker, Jacob Z., Petrosino, Jennifer M., Martens, Colton R., Hinger, Scott A., Royer, Charlotte J., Dorn, Lisa E., Branch, Daniel A., Serrano, Joan, Stanford, Kristin I., Kyriazis, George A., Baskin, Kedryn K., Accornero, Federica
Published in Molecular metabolism (Germany) (01.12.2021)
Published in Molecular metabolism (Germany) (01.12.2021)
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Journal Article
Saccharin Stimulates Insulin Secretion Dependent on Sweet Taste Receptor-Induced Activation of PLC Signaling Axis
Serrano, Joan, Meshram, Nishita N, Soundarapandian, Mangala M, Smith, Kathleen R, Mason, Carter, Brown, Ian S, Tyrberg, Björn, Kyriazis, George A
Published in Biomedicines (01.01.2022)
Published in Biomedicines (01.01.2022)
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Journal Article
Mitochondrial Uncoupling Protein-4 Regulates Calcium Homeostasis and Sensitivity to Store Depletion-induced Apoptosis in Neural Cells
Chan, Sic.L., Liu, Dong, Kyriazis, George A., Bagsiyao, Pamela, Ouyang, Xin, Mattson, Mark P.
Published in The Journal of biological chemistry (08.12.2006)
Published in The Journal of biological chemistry (08.12.2006)
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Journal Article
Regulation of HAX-1 Anti-apoptotic Protein by Omi/HtrA2 Protease during Cell Death
Cilenti, Lucia, Soundarapandian, Mangala M., Kyriazis, George A., Stratico, Valerie, Singh, Supriya, Gupta, Sanjeev, Bonventre, Joseph V., Alnemri, Emad S., Zervos, Antonis S.
Published in The Journal of biological chemistry (26.11.2004)
Published in The Journal of biological chemistry (26.11.2004)
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The Homocysteine-inducible Endoplasmic Reticulum Stress Protein Counteracts Calcium Store Depletion and Induction of CCAAT Enhancer-binding Protein Homologous Protein in a Neurotoxin Model of Parkinson Disease
Chigurupati, Srinivasulu, Wei, Zelan, Belal, Cherine, Vandermey, Myriam, Kyriazis, George A., Arumugam, Thiruma V., Chan, Sic L.
Published in The Journal of biological chemistry (03.07.2009)
Published in The Journal of biological chemistry (03.07.2009)
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Journal Article
Stress-induced Switch in Numb Isoforms Enhances Notch-dependent Expression of Subtype-specific Transient Receptor Potential Channel
Kyriazis, George A., Belal, Cherine, Madan, Meenu, Taylor, David G., Wang, Jang, Wei, Zelan, Pattisapu, Jogi V., Chan, Sic L.
Published in The Journal of biological chemistry (26.02.2010)
Published in The Journal of biological chemistry (26.02.2010)
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Journal Article
Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells
Cilenti, Lucia, Kyriazis, George A, Soundarapandian, Mangala M, Stratico, Valerie, Yerkes, Adam, Park, Kwon Moo, Sheridan, Alice M, Alnemri, Emad S, Bonventre, Joseph V, Zervos, Antonis S
Published in American journal of physiology. Renal physiology (01.02.2005)
Published in American journal of physiology. Renal physiology (01.02.2005)
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Journal Article
A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study
Serrano, Joan, Kondo, Saki, Link, Grace M., Brown, Ian S., Pratley, Richard E., Baskin, Kedryn K., Goodpaster, Bret H., Coen, Paul M., Kyriazis, George A.
Published in Metabolism, clinical and experimental (10.10.2024)
Published in Metabolism, clinical and experimental (10.10.2024)
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Journal Article
Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity
Smith, Kathleen R, Hussain, Tania, Karimian Azari, Elnaz, Steiner, Jennifer L, Ayala, Julio E, Pratley, Richard E, Kyriazis, George A
Published in American journal of physiology: endocrinology and metabolism (15.04.2016)
Published in American journal of physiology: endocrinology and metabolism (15.04.2016)
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Journal Article
NIH Workshop Report: sensory nutrition and disease
Reed, Danielle R, Alhadeff, Amber L, Beauchamp, Gary K, Chaudhari, Nirupa, Duffy, Valerie B, Dus, Monica, Fontanini, Alfredo, Glendinning, John I, Green, Barry G, Joseph, Paule V, Kyriazis, George A, Lyte, Mark, Maruvada, Padma, McGann, John P, McLaughlin, John T, Moran, Timothy H, Murphy, Claire, Noble, Emily E, Pepino, M Yanina, Pluznick, Jennifer L, Rother, Kristina I, Saez, Enrique, Spector, Alan C, Sternini, Catia, Mattes, Richard D
Published in The American journal of clinical nutrition (01.01.2021)
Published in The American journal of clinical nutrition (01.01.2021)
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The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins
Belal, Cherine, Ameli, Neema J., El Kommos, Adam, Bezalel, Spencer, Al'Khafaji, Aziz M., Mughal, Mohamed R., Mattson, Mark P., Kyriazis, George A., Tyrberg, Björn, Chan, Sic L.
Published in Human molecular genetics (01.03.2012)
Published in Human molecular genetics (01.03.2012)
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