New Antitumor Substances, FR901463, FR901464 and FR901465: II. Activities against Experimental Tumors in Mice and Mechanism of Action
NAKAJIMA, HIDENORI, HORI, YASUHIRO, TERANO, HIROSHI, OKUHARA, MASAKUNI, MANDA, TOSHITAKA, MATSUMOTO, SANAE, SHIMOMURA, KYOICHI
Published in Journal of antibiotics (01.12.1996)
Published in Journal of antibiotics (01.12.1996)
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FR901228, A NOVEL ANTITUMOR BICYCLIC DEPSIPEPTIDE PRODUCED BY Chromobacterium violaceum No. 968: III. ANTITUMOR ACTIVITIES ON EXPERIMENTAL TUMORS IN MICE
UEDA, HIROTSUGU, MANDA, TOSHITAKA, MATSUMOTO, SANAE, MUKUMOTO, SUEO, NISHIGAKI, FUSAKO, KAWAMURA, IKUO, SHIMOMURA, KYOICHI
Published in Journal of antibiotics (1994)
Published in Journal of antibiotics (1994)
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Difference between Normal and WHHL Rabbits in Susceptibility to the Adrenal Toxicity of an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, FR145237
Matsuo, Masahiko, Hashimoto, Masaharu, Suzuki, Jyunya, Iwanami, Kohki, Tomoi, Masaaki, Shimomura, Kyoichi
Published in Toxicology and applied pharmacology (01.10.1996)
Published in Toxicology and applied pharmacology (01.10.1996)
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Anti‐cachectic Effect of FK317, a Novel Anti‐cancer Agent, in Colon26 and LX‐1 Models in Mice
Naoe, Yoshinori, Kawamura, Ikuo, Inami, Masamichi, Matsumoto, Sanae, Nishigaki, Fusako, Tsujimoto, Susumu, Manda, Toshitaka, Shimomura, Kyoichi
Published in Cancer science (01.12.1998)
Published in Cancer science (01.12.1998)
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FK317, a Novel Substituted Dihydrobenzoxazine, Exhibits Potent Antitumor Activity against Human Tumor Xenografts in Nude Mice
Naoe, Yoshinori, Inami, Masamichi, Matsumoto, Sanae, Takagaki, Shoji, Fujiwara, Tomoichi, Yamazaki, Sachiko, Kawamura, Ikuo, Nishigaki, Fusako, Tsujimoto, Susumu, Manda, Toshitaka, Shimomura, Kyoichi
Published in Cancer science (01.12.1998)
Published in Cancer science (01.12.1998)
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Different Effects of FK317 on Multidrug‐resistant Tumor in vivo and in vitro
Naoe, Yoshinori, Inami, Masamichi, Takagaki, Shoji, Matsumoto, Sanae, Kawamura, Ikuo, Nishigaki, Fusako, Tsujimoto, Susumu, Manda, Toshitaka, Shimomura, Kyoichi
Published in Cancer science (01.10.1998)
Published in Cancer science (01.10.1998)
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Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall
Matsuo, Masahiko, Ito, Futoshi, Konto, Akiko, Aketa, Miho, Tomoi, Masaaki, Shimomura, Kyoichi
Published in Biochimica et biophysica acta (07.12.1995)
Published in Biochimica et biophysica acta (07.12.1995)
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High‐level Production, Chemical Modification and Site‐directed Mutagenesis of a Cephalosporin C Acylase from Pseudomonas Strain N176
Ishii, Yoshinori, Saito, Yoshimasa, Fujimura, Takao, Sasaki, Hitoshi, Noguchi, Yuji, Yamada, Hisashi, Niwa, Mineo, Shimomura, Kyoichi
Published in European journal of biochemistry (01.06.1995)
Published in European journal of biochemistry (01.06.1995)
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A New Aromatase Inhibitor, FR901537: II. Pharmacological and Antitumor Effects
OOHATA, NOBUTAKA, KAWAMURA, IKUO, LACEY, ELIZABETH, NISHIGAKI, FUSAKO, MATSUMOTO, SANAE, TSUJIMOTO, SUSUMU, NAOE, YOSHINORI, MANDA, TOSHITAKA, SHIMOMURA, KYOICHI
Published in Journal of antibiotics (1995)
Published in Journal of antibiotics (1995)
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The Induction of Interleukin-6 (IL-6) and Colony-Stimulating Factors (CSFs) by FK565 and Its Thrombopoietic Activity Following in Vivo Administration
MAEDA, Masahiro, SUZUKI, Shingo, OHTSUKA, Kazuyuki, SATOH, Susumu, NISHIGAKI, Fusako, SHIMOMURA, Kyoichi, IMAI, Yuko, NIWA, Mineo, KOHSAKA, Masanobu
Published in Biological & pharmaceutical bulletin (1994)
Published in Biological & pharmaceutical bulletin (1994)
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Bromine Residue at Hydrophilic Region Influences Biological Activity of Aplysiatoxin, a Tumor Promoter
Shimomura, Kyoichi, Mullinix, Mary G., Kakunaga, Takeo, Fujiki, Hirota, Sugimura, Takashi
Published in Science (American Association for the Advancement of Science) (16.12.1983)
Published in Science (American Association for the Advancement of Science) (16.12.1983)
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A NEW ANTITUMOR ANTIBIOTIC, FR900840: III. ANTITUMOR ACTIVITY AGAINST EXPERIMENTAL TUMORS
NISHIMURA, MAKOTO, NAKADA, HIROHISA, KAWAMURA, IKUO, MIZOTA, TAMOTSU, SHIMOMURA, KYOICHI, NAKAHARA, KUNIO, GOTO, TOSHIO, YAMAGUCHI, ISAMU, OKUHARA, MASAKUNI
Published in Journal of antibiotics (1989)
Published in Journal of antibiotics (1989)
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Effects of a novel orally-active antiallergic drug, quinotolast (FK021), on airway clearance
Imai, T, Kai, H, Isohama, Y, Takahama, K, Miyata, T, Hiroi, J, Shimomura, K, Kohsaka, M
Published in Nihon yakurigaku zasshi (1994)
Published in Nihon yakurigaku zasshi (1994)
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Cloning of genes coding for L-sorbose and L-sorbosone dehydrogenases from Gluconobacter oxydans and microbial production of 2-keto-L-gulonate, a precursor of L-ascorbic acid, in a recombinant G. oxydans strain
SAITO, Y, ISHII, Y, HOSODA, J, SHIMOMURA, K, HAYASHI, H, IMAO, Y, AKASHI, T, YOSHIKAWA, K, NOGUCHI, Y, SOEDA, S, YOSHIDA, M, NIWA, M
Published in Applied and Environmental Microbiology (01.02.1997)
Published in Applied and Environmental Microbiology (01.02.1997)
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Analgesic Effect of Morphine Glucuronides
SHIMOMURA, KYOICHI, KAMATA, OSAMU, UEKI, SHOWA, IDA, SEIU, OGURI, KAZUTA, YOSHIMURA, HIDETOSHI, TSUKAMOTO, HISAO
Published in The Tohoku Journal of Experimental Medicine (01.01.1971)
Published in The Tohoku Journal of Experimental Medicine (01.01.1971)
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