Xenobiotic receptors and the regulation of intestinal homeostasis: harnessing the chemical output of the intestinal microbiota
Nieves, Kristoff M, Hirota, Simon A, Flannigan, Kyle L
Published in American journal of physiology: Gastrointestinal and liver physiology (01.02.2022)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.02.2022)
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Journal Article
Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics
Wallace, John L, Blackler, Rory W, Chan, Melissa V, Da Silva, Gabriela J, Elsheikh, Wagdi, Flannigan, Kyle L, Gamaniek, Iulia, Manko, Anna, Wang, Lu, Motta, Jean-Paul, Buret, Andre G
Published in Antioxidants & redox signaling (10.02.2015)
Published in Antioxidants & redox signaling (10.02.2015)
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Journal Article
Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage
Medina-Contreras, Oscar, Harusato, Akihito, Nishio, Hikaru, Flannigan, Kyle L, Ngo, Vu, Leoni, Giovanna, Neumann, Philipp-Alexander, Geem, Duke, Lili, Loukia N, Ramadas, Ravisankar A, Chassaing, Benoit, Gewirtz, Andrew T, Kohlmeier, Jacob E, Parkos, Charles A, Towne, Jennifer E, Nusrat, Asma, Denning, Timothy L
Published in The Journal of immunology (1950) (01.01.2016)
Published in The Journal of immunology (1950) (01.01.2016)
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Journal Article
Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production
Motta, Jean-Paul, Flannigan, Kyle L, Agbor, Terence A, Beatty, Jennifer K, Blackler, Rory W, Workentine, Matthew L, Da Silva, Gabriela J, Wang, Rui, Buret, Andre G, Wallace, John L
Published in Inflammatory bowel diseases (01.05.2015)
Published in Inflammatory bowel diseases (01.05.2015)
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Journal Article
Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis
Flannigan, Kyle L., Agbor, Terence A., Blackler, Rory W., Kim, Janice J., Khan, Waliul I., Verdu, Elena F., Ferraz, Jose G. P., Wallace, John L.
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
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Journal Article
Constitutive androstane receptor regulates the intestinal mucosal response to injury
Hudson, Grace M, Flannigan, Kyle L, Erickson, Sarah L, Vicentini, Fernando A, Zamponi, Alexandra, Hirota, Christina L, Alston, Laurie, Altier, Christophe, Ghosh, Subrata, Rioux, Kevin P, Mani, Sridhar, Chang, Thomas K, Hirota, Simon A
Published in British journal of pharmacology (01.06.2017)
Published in British journal of pharmacology (01.06.2017)
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Journal Article
Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3 + Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis
Abo, Hirohito, Flannigan, Kyle L, Geem, Duke, Ngo, Vu L, Harusato, Akihito, Denning, Timothy L
Published in Frontiers in immunology (14.03.2019)
Published in Frontiers in immunology (14.03.2019)
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Journal Article
Phenotypic and functional profiling of mouse intestinal antigen presenting cells
Harusato, Akihito, Flannigan, Kyle L., Geem, Duke, Denning, Timothy L.
Published in Journal of immunological methods (01.06.2015)
Published in Journal of immunological methods (01.06.2015)
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Journal Article
Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis
Paul-Clark, Mark, Elsheikh, Wagdi, Kirkby, Nicholas, Chan, Melissa, Devchand, Pallavi, Agbor, Terence A, Flannigan, Kyle L, Cheadle, Charlotte, Freydin, Maxim, Ianaro, Angela, Mitchell, Jane A, Wallace, John L
Published in PloS one (2016)
Published in PloS one (2016)
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Journal Article
Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation
Flannigan, Kyle L, Geem, Duke, Harusato, Akihito, Denning, Timothy L
Published in The American journal of pathology (01.07.2015)
Published in The American journal of pathology (01.07.2015)
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Journal Article
Calcitonin gene-related peptide promotes epithelial reparative and anti-colitic functions of IL-4 educated human macrophages
Callejas, Blanca E, Sousa, James A, Flannigan, Kyle L, Wang, Arthur, Higgins, Eve, Herik, Aydin Ivan, Li, Shuhua, Rajeev, Sruthi, Rosentreter, Ryan, Panaccione, Remo, McKay, Derek M
Published in American journal of physiology: Gastrointestinal and liver physiology (08.10.2024)
Published in American journal of physiology: Gastrointestinal and liver physiology (08.10.2024)
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Journal Article
The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins
Erickson, Sarah L., Alston, Laurie, Nieves, Kristoff, Chang, Thomas K. H., Mani, Sridhar, Flannigan, Kyle L., Hirota, Simon A.
Published in The FASEB journal (01.02.2020)
Published in The FASEB journal (01.02.2020)
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Journal Article
An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil
Flannigan, Kyle L., Taylor, Michael R., Pereira, Sheldon K., Rodriguez-Arguello, Jimena, Moffat, Andrew W., Alston, Laurie, Wang, Xuemei, Poon, Karen K., Beck, Paul L., Rioux, Kevin P., Jonnalagadda, Mahesh, Chelikani, Prasanth K., Galipeau, Heather J., Lewis, Ian A., Workentine, Matthew L., Greenway, Steven C., Hirota, Simon A.
Published in The Journal of heart and lung transplantation (01.09.2018)
Published in The Journal of heart and lung transplantation (01.09.2018)
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Journal Article
Vancomycin relieves mycophenolate mofetil-induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity
Taylor, Michael R, Flannigan, Kyle L, Rahim, Hannah, Mohamud, Amina, Lewis, Ian A, Hirota, Simon A, Greenway, Steven C
Published in Science advances (01.08.2019)
Published in Science advances (01.08.2019)
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Journal Article
NR4A1 modulates intestinal smooth muscle cell phenotype and dampens inflammation-associated intestinal remodeling
Szczepanski, Holly E, Flannigan, Kyle L, Mainoli, Barbara, Alston, Laurie, Baruta, Grace M, Lee, Joshua W, Venu, Vivek Krishna Pulakazhi, Shearer, Jane, Dufour, Antoine, Hirota, Simon A
Published in The FASEB journal (01.11.2022)
Published in The FASEB journal (01.11.2022)
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Journal Article
Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation
Hudson, Grace, Flannigan, Kyle L, Venu, Vivek Krishna Pulakazhi, Alston, Laurie, Sandall, Christina F, MacDonald, Justin A, Muruve, Daniel A, Chang, Thomas K H, Mani, Sridhar, Hirota, Simon A
Published in The Journal of pharmacology and experimental therapeutics (01.07.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2019)
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