Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy
Willoughby, Catherine E, Jiang, Yanyan, Thomas, Huw D, Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J, Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M Raymond V, Turner, Paul, Munck, Joanne M, Griffin, Roger J, Rennison, Tommy, Pickles, James, Cano, Celine, Newell, David R, Reeves, Helen L, Ryan, Anderson J, Wedge, Stephen R
Published in The Journal of clinical investigation (01.01.2020)
Published in The Journal of clinical investigation (01.01.2020)
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Journal Article
Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer
Batey, Michael A, Zhao, Yan, Kyle, Suzanne, Richardson, Caroline, Slade, Andrew, Martin, Niall M B, Lau, Alan, Newell, David R, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.06.2013)
Published in Molecular cancer therapeutics (01.06.2013)
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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial
Thomas, Huw D, Calabrese, Christopher R, Batey, Michael A, Canan, Stacie, Hostomsky, Zdenek, Kyle, Suzanne, Maegley, Karen A, Newell, David R, Skalitzky, Donald, Wang, Lan-Zhen, Webber, Stephen E, Curtin, Nicola J
Published in Molecular cancer therapeutics (01.03.2007)
Published in Molecular cancer therapeutics (01.03.2007)
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Vasoactivity of AG014699, a Clinically Active Small Molecule Inhibitor of Poly(ADP-ribose) Polymerase: a Contributory Factor to Chemopotentiation In vivo?
ALI, Majid, TELFER, Brian A, CURTIN, Nicola J, WILLIAMS, Kaye J, MCCRUDDEN, Cian, O'ROURKE, Martin, THOMAS, Huw D, KAMJOO, Marzieh, KYLE, Suzanne, ROBSON, Tracy, SHAW, Chris, HIRST, David G
Published in Clinical cancer research (01.10.2009)
Published in Clinical cancer research (01.10.2009)
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Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells
CURTIN, Nicola J, WANG, Lan-Zhen, NEWELL, David R, YIAKOUVAKI, Anthie, KYLE, Suzanne, ARRIS, Christine A, CANAN-KOCH, Stacie, WEBBER, Stephen E, DURKACZ, Barbara W, CALVERT, Hilary A, HOSTOMSKY, Zdenek
Published in Clinical cancer research (01.02.2004)
Published in Clinical cancer research (01.02.2004)
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Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines
DELANEY, C. A, WANG, L.-Z, KYLE, S, WHITE, A. W, CALVERT, A. H, CURTIN, N. J, DURKACZ, B. W, HOSTOMSKY, Z, NEWELL, D. R
Published in Clinical cancer research (01.07.2000)
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Published in Clinical cancer research (01.07.2000)
Journal Article
Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors
Mukhopadhyay, Asima, Elattar, Ahmed, Cerbinskaite, Aiste, Wilkinson, Sarah J, Drew, Yvette, Kyle, Suzanne, Los, Gerrit, Hostomsky, Zdenek, Edmondson, Richard J, Curtin, Nicola J
Published in Clinical cancer research (15.04.2010)
Published in Clinical cancer research (15.04.2010)
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Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2
DREW, Yvette, MULLIGAN, Evan A, EDMONDSON, Richard J, CURTIN, Nicola J, VONG, Wan-Tse, THOMAS, Huw D, KAHN, Samra, KYLE, Suzanne, MUKHOPADHYAY, Asima, LOS, Gerrit, HOSTOMSKY, Zdenek, PLUMMER, Elizabeth R
Published in JNCI : Journal of the National Cancer Institute (16.02.2011)
Published in JNCI : Journal of the National Cancer Institute (16.02.2011)
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helleday, Thomas, Bryant, Helen E, Schultz, Niklas, Thomas, Huw D, Parker, Kayan M, Flower, Dan, Lopez, Elena, Kyle, Suzanne, Meuth, Mark, Curtin, Nicola J
Published in Nature (14.04.2005)
Published in Nature (14.04.2005)
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Journal Article
6-Thioguanine Selectively Kills BRCA2-Defective Tumors and Overcomes PARP Inhibitor Resistance
ISSAEVA, Natalia, THOMAS, Huw D, CHATZAKOS, Vicky, MULLIGAN, Evan A, LUNDIN, Cecilia, GUBANOVA, Evgenia, KERSBERGEN, Ariena, HARRIS, Adrian L, SHARMA, Ricky A, ROTTENBERG, Sven, CURTIN, Nicola J, HELLEDAY, Thomas, DJURENOVIC, Tatjana, JASPERS, Janneke E, STOIMENOV, Ivaylo, KYLE, Suzanne, PEDLEY, Nicholas, GOTTIPATI, Ponnari, ZUR, Rafal, SLEETH, Kate
Published in Cancer research (Chicago, Ill.) (01.08.2010)
Published in Cancer research (Chicago, Ill.) (01.08.2010)
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The clinically active PARP inhibitor AG014699 ameliorates cardiotoxicity but does not enhance the efficacy of doxorubicin, despite improving tumor perfusion and radiation response in mice
Ali, Majid, Kamjoo, Marzieh, Thomas, Huw D, Kyle, Suzanne, Pavlovska, Ivanda, Babur, Muhammed, Telfer, Brian A, Curtin, Nicola J, Williams, Kaye J
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
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PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS
Almeida, Gilberto S., Bawn, Carlo M., Galler, Martin, Wilson, Ian, Thomas, Huw D., Kyle, Suzanne, Curtin, Nicola J., Newell, David R., Maxwell, Ross J.
Published in NMR in biomedicine (01.09.2017)
Published in NMR in biomedicine (01.09.2017)
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Journal Article
Abstract 3333: Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index
Willmore, Elaine, Ahn, Maria, Kyle, Suzanne, Zhao, Yan, Thomas, Huw, Rankin, Kenneth S., Bevan, Luke, Fazal, Lynsey, Hearn, Keisha, Wilsher, Nicola, Kucia-Tran, Justyna, Ferrari, Nicola, Wallis, Nicola, Thompson, Neil, Lyons, John, Miller, Duncan, Cano, Celine, Noble, Martin E., Hardcastle, Ian R., Howard, Steven, Chessari, Gianni, Lunec, John, Newell, David R., Wedge, Steve R.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361
CALABRESE, Christopher R, ALMASSY, Robert, LI, Jianke, MAEGLEY, Karen, NEWELL, David R, NOTARIANNI, Elena, STRATFORD, Ian J, SKALITZKY, Donald, THOMAS, Huw D, WANG, Ian-Zhen, WEBBER, Stephen E, WILLIAMS, Kaye J, BARTON, Stephanie, CURTIN, Nicola J, BATEY, Michael A, CALVERT, A. Hilary, CANAN-KOCH, Stacie, DURKACZ, Barbara W, HOSTOMSKY, Zdenek, KUMPF, Robert A, KYLE, Suzanne
Published in JNCI : Journal of the National Cancer Institute (07.01.2004)
Published in JNCI : Journal of the National Cancer Institute (07.01.2004)
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Abstract 6588: Discovery of ASTX295, a potent, next-generation small molecule antagonist of MDM2 with differentiated pharmacokinetic profile
Ahn, Maria, Bevan, Luke, Buck, Ildiko, Cano, Celine, Castro, Juan, Cons, Ben, Endicott, Jane, Fazal, Lynsey, Ferrari, Nicola, Hardcastle, Ian, Hearn, Keisha, Holvey, Rhian, Howard, Steven, Johnson, Chris, Jennings, Claire, Kucia-Tran, Justyna, Kyle, Suzanne, Lunec, John, Lyons, John, Miller, Duncan, Rees, David, Noble, Martin, Newell, David R., Reeks, Judith, Saini, Harpreet, St. Denis, Jeffrey, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil, Vinkovic, Mladen, Ward, George, Wallis, Nicola, Walton, Hugh, Wedge, Stephen, Williams, Pamela, Willmore, Elaine, Wilshire, Nicola, Zhao, Yan, Chessari, Gianni
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract C75: Rucaparib (CO-338) accumulation and persistence of PARP inhibition in vitro and in vivo and efficacy of intermittent vs continuous schedules
Murray, James C., Thomas, Huw D., Berry, Philip, Kyle, Suzanne, Jones, Christopher, Plummer, Ruth, Boddy, Alan V., Curtin, Nicola J.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Abstract 5399: Growth inhibition, cytotoxicity and signaling studies of PI3K & MEK inhibitor combinations in colorectal carcinoma cell lines
Cox, Emma J., Kyle, Suzanne, Beale, Gary S., Maxwell, Ross J., Newell, David R.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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