Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit
Byrn, Randal A, Jones, Steven M, Bennett, Hamilton B, Bral, Chris, Clark, Michael P, Jacobs, Marc D, Kwong, Ann D, Ledeboer, Mark W, Leeman, Joshua R, McNeil, Colleen F, Murcko, Mark A, Nezami, Azin, Perola, Emanuele, Rijnbrand, Rene, Saxena, Kumkum, Tsai, Alice W, Zhou, Yi, Charifson, Paul S
Published in Antimicrobial agents and chemotherapy (01.03.2015)
Published in Antimicrobial agents and chemotherapy (01.03.2015)
Get full text
Journal Article
Telaprevir and pegylated interferon–alpha‐2a inhibit wild‐type and resistant genotype 1 hepatitis C virus replication in patients
Kieffer, Tara L., Sarrazin, Christoph, Miller, Janice S., Welker, Martin W., Forestier, Nicole, Reesink, Hendrik W., Kwong, Ann D., Zeuzem, Stefan
Published in Hepatology (Baltimore, Md.) (01.09.2007)
Published in Hepatology (Baltimore, Md.) (01.09.2007)
Get full text
Journal Article
Hepatitis C Virus Variants with Decreased Sensitivity to Direct-Acting Antivirals (DAAs) Were Rarely Observed in DAA-Naive Patients prior to Treatment
Bartels, Doug J, Sullivan, James C, Zhang, Eileen Z, Tigges, Ann M, Dorrian, Jennifer L, De Meyer, Sandra, Takemoto, Darin, Dondero, Elizabeth, Kwong, Ann D, Picchio, Gaston, Kieffer, Tara L
Published in Journal of Virology (01.02.2013)
Published in Journal of Virology (01.02.2013)
Get full text
Journal Article
Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials
Kieffer, Tara L, De Meyer, Sandra, Bartels, Doug J, Sullivan, James C, Zhang, Eileen Z, Tigges, Ann, Dierynck, Inge, Spanks, Joan, Dorrian, Jennifer, Jiang, Min, Adiwijaya, Bambang, Ghys, Anne, Beumont, Maria, Kauffman, Robert S, Adda, Nathalie, Jacobson, Ira M, Sherman, Kenneth E, Zeuzem, Stefan, Kwong, Ann D, Picchio, Gaston
Published in PloS one (12.04.2012)
Published in PloS one (12.04.2012)
Get full text
Journal Article
Natural Prevalence of Hepatitis C Virus Variants with Decreased Sensitivity to NS3·4A Protease Inhibitors in Treatment-Naive Subjects
Bartels, Doug J., Zhou, Yi, Zhang, Eileen Z., Marcial, Michelle, Byrn, Randal A., Pfeiffer, Thomas, Tigges, Ann M., Adiwijaya, Bambang S., Lin, Chao, Kwong, Ann D., Kieffer, Tara L.
Published in The Journal of infectious diseases (15.09.2008)
Published in The Journal of infectious diseases (15.09.2008)
Get full text
Journal Article
SARS-CoV-2 viral dynamics in a placebo-controlled phase 2 study of patients infected with the SARS-CoV-2 Omicron variant and treated with pomotrelvir
Borroto-Esoda, Katyna, Wilfret, David, Tong, Xiao, Plummer, Andrew, Kearney, Brian, Kwong, Ann D
Published in Microbiology spectrum (06.02.2024)
Published in Microbiology spectrum (06.02.2024)
Get full text
Journal Article
A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants
Adiwijaya, Bambang S, Herrmann, Eva, Hare, Brian, Kieffer, Tara, Lin, Chao, Kwong, Ann D, Garg, Varun, Randle, John C R, Sarrazin, Christoph, Zeuzem, Stefan, Caron, Paul R
Published in PLoS computational biology (01.04.2010)
Published in PLoS computational biology (01.04.2010)
Get full text
Journal Article
In Vitro Studies of Cross-resistance Mutations against Two Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061
Lin, Chao, Gates, Cynthia A., Rao, B. Govinda, Brennan, Debra L., Fulghum, John R., Luong, Yu-Ping, Frantz, J. Daniel, Lin, Kai, Ma, Sue, Wei, Yun-Yi, Perni, Robert B., Kwong, Ann D.
Published in The Journal of biological chemistry (04.11.2005)
Published in The Journal of biological chemistry (04.11.2005)
Get full text
Journal Article
Restoration of the Activated Rig-I Pathway in Hepatitis C Virus (HCV) Replicon Cells by HCV Protease, Polymerase, and NS5A Inhibitors In Vitro at Clinically Relevant Concentrations
KALKERI, Gururaj, CHAO LIN, GOPILAN, Jenna, SLOAN, Kevin, RIJNBRAND, Rene, KWONG, Ann D
Published in Antimicrobial Agents and Chemotherapy (01.09.2013)
Published in Antimicrobial Agents and Chemotherapy (01.09.2013)
Get full text
Journal Article
Accelerating antiviral drug discovery: lessons from COVID-19
von Delft, Annette, Hall, Matthew D, Kwong, Ann D, Purcell, Lisa A, Saikatendu, Kumar Singh, Schmitz, Uli, Tallarico, John A, Lee, Alpha A
Published in Nature reviews. Drug discovery (01.07.2023)
Published in Nature reviews. Drug discovery (01.07.2023)
Get full text
Journal Article
Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens
Tong, Xiao, Smith, Jeanon, Bukreyeva, Natalya, Koma, Takaaki, Manning, John T., Kalkeri, Raj, Kwong, Ann D., Paessler, Slobodan
Published in Antiviral research (01.01.2018)
Published in Antiviral research (01.01.2018)
Get full text
Journal Article
Evaluation of in vitro antiviral activity of SARS-CoV-2 Mpro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions
Tong, Xiao, Keung, Walter, Arnold, Lee D, Stevens, Laura J, Pruijssers, Andrea J, Kook, Seunghyi, Lopatin, Uri, Denison, Mark, Kwong, Ann D
Published in Antimicrobial agents and chemotherapy (15.11.2023)
Published in Antimicrobial agents and chemotherapy (15.11.2023)
Get full text
Journal Article
Evaluation of in vitro antiviral activity of SARS-CoV-2 M pro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions
Tong, Xiao, Keung, Walter, Arnold, Lee D, Stevens, Laura J, Pruijssers, Andrea J, Kook, Seunghyi, Lopatin, Uri, Denison, Mark, Kwong, Ann D
Published in Antimicrobial agents and chemotherapy (15.11.2023)
Published in Antimicrobial agents and chemotherapy (15.11.2023)
Get full text
Journal Article
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
Sarrazin, Christoph, Kieffer, Tara L, Bartels, Doug, Hanzelka, Brian, Müh, Ute, Welker, Martin, Wincheringer, Dennis, Zhou, Yi, Chu, Hui-May, Lin, Chao, Weegink, Christine, Reesink, Henk, Zeuzem, Stefan, Kwong, Ann D
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2007)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2007)
Get more information
Journal Article