Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility
Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Chan, Wan-Mui, Fan, Zhimeng, Tsoi, Hoi-Wah, Wen, Lei, Liang, Ronghui, Cao, Jianli, Chen, Yanxia, Tang, Kaiming, Luo, Cuiting, Cai, Jian-Piao, Kok, Kin-Hang, Chu, Hin, Chan, Kwok-Hung, Sridhar, Siddharth, Chen, Zhiwei, Chen, Honglin, To, Kelvin Kai-Wang, Yuen, Kwok-Yung
Published in Clinical Infectious Diseases (26.03.2020)
Published in Clinical Infectious Diseases (26.03.2020)
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Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19)
Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Zhang, Anna Jinxia, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Fan, Zhimeng, Li, Can, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Luo, Cuiting, Cheng, Vincent Chi-Chung, Cai, Jian-Piao, Chu, Hin, Chan, Kwok-Hung, To, Kelvin Kai-Wang, Sridhar, Siddharth, Yuen, Kwok-Yung
Published in Clinical infectious diseases (19.11.2020)
Published in Clinical infectious diseases (19.11.2020)
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Differentiated human airway organoids to assess infectivity of emerging influenza virus
Zhou, Jie, Li, Cun, Sachs, Norman, Chiu, Man Chun, Wong, Bosco Ho-Yin, Chu, Hin, Poon, Vincent Kwok-Man, Wang, Dong, Zhao, Xiaoyu, Wen, Lei, Song, Wenjun, Yuan, Shuofeng, Wong, Kenneth Kak-Yuen, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Chen, Honglin, Clevers, Hans, Yuen, Kwok-Yung
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2018)
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Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters
Yuan, Shuofeng, Ye, Zi-Wei, Liang, Ronghui, Tang, Kaiming, Zhang, Anna Jinxia, Lu, Gang, Ong, Chon Phin, Man Poon, Vincent Kwok, Chan, Chris Chung-Sing, Mok, Bobo Wing-Yee, Qin, Zhenzhi, Xie, Yubin, Chu, Allen Wing-Ho, Chan, Wan-Mui, Ip, Jonathan Daniel, Sun, Haoran, Tsang, Jessica Oi-Ling, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Lu, Lu, Yip, Cyril Chik-Yan, Chu, Hin, To, Kelvin Kai-Wang, Chen, Honglin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Published in Science (American Association for the Advancement of Science) (22.07.2022)
Published in Science (American Association for the Advancement of Science) (22.07.2022)
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Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters
Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chu, Hin, Chan, Jasper Fuk-Woo, Fan, Zhimeng, Li, Can, Liu, Feifei, Chen, Yanxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Wu, Kenneth Lap-Kei, Sridhar, Siddharth, Chan, Ying-Shing, Yuen, Kwok-Yung
Published in Clinical infectious diseases (15.07.2021)
Published in Clinical infectious diseases (15.07.2021)
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster
Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Kok, Kin-Hang, To, Kelvin Kai-Wang, Chu, Hin, Yang, Jin, Xing, Fanfan, Liu, Jieling, Yip, Cyril Chik-Yan, Poon, Rosana Wing-Shan, Tsoi, Hoi-Wah, Lo, Simon Kam-Fai, Chan, Kwok-Hung, Poon, Vincent Kwok-Man, Chan, Wan-Mui, Ip, Jonathan Daniel, Cai, Jian-Piao, Cheng, Vincent Chi-Chung, Chen, Honglin, Hui, Christopher Kim-Ming, Yuen, Kwok-Yung
Published in The Lancet (15.02.2020)
Published in The Lancet (15.02.2020)
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Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters
Zhang, Anna Jinxia, Lee, Andrew Chak-Yiu, Chan, Jasper Fuk-Woo, Liu, Feifei, Li, Can, Chen, Yanxia, Chu, Hin, Lau, Siu-Ying, Wang, Pui, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Yuan, Shuofeng, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung
Published in Clinical infectious diseases (15.06.2021)
Published in Clinical infectious diseases (15.06.2021)
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SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target
Yuan, Shuofeng, Chu, Hin, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Wen, Lei, Yan, Bingpeng, Lai, Pok-Man, Tee, Kah-Meng, Huang, Jingjing, Chen, Dongdong, Li, Cun, Zhao, Xiaoyu, Yang, Dong, Chiu, Man Chun, Yip, Cyril, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Sze, Kong-Hung, Zhou, Jie, Chan, Ivy Hau-Yee, Kok, Kin-Hang, To, Kelvin Kai-Wang, Kao, Richard Yi-Tsun, Lau, Johnson Yiu-Nam, Jin, Dong-Yan, Perlman, Stanley, Yuen, Kwok-Yung
Published in Nature Communications (10.01.2019)
Published in Nature Communications (10.01.2019)
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Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis
Zhou, Jie, Chu, Hin, Li, Cun, Wong, Bosco Ho-Yin, Cheng, Zhong-Shan, Poon, Vincent Kwok-Man, Sun, Tianhao, Lau, Candy Choi-Yi, Wong, Kenneth Kak-Yuen, Chan, Jimmy Yu-Wai, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Chan, Kwok-Hung, Zheng, Bo-Jian, Yuen, Kwok-Yung
Published in The Journal of Infectious Diseases (01.05.2014)
Published in The Journal of Infectious Diseases (01.05.2014)
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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Riva, Laura, Yuan, Shuofeng, Yin, Xin, Martin-Sancho, Laura, Matsunaga, Naoko, Pache, Lars, Burgstaller-Muehlbacher, Sebastian, De Jesus, Paul D., Teriete, Peter, Hull, Mitchell V., Chang, Max W., Chan, Jasper Fuk-Woo, Cao, Jianli, Poon, Vincent Kwok-Man, Herbert, Kristina M., Cheng, Kuoyuan, Nguyen, Tu-Trinh H., Rubanov, Andrey, Pu, Yuan, Nguyen, Courtney, Choi, Angela, Rathnasinghe, Raveen, Schotsaert, Michael, Miorin, Lisa, Dejosez, Marion, Zwaka, Thomas P., Sit, Ko-Yung, Martinez-Sobrido, Luis, Liu, Wen-Chun, White, Kris M., Chapman, Mackenzie E., Lendy, Emma K., Glynne, Richard J., Albrecht, Randy, Ruppin, Eytan, Mesecar, Andrew D., Johnson, Jeffrey R., Benner, Christopher, Sun, Ren, Schultz, Peter G., Su, Andrew I., García-Sastre, Adolfo, Chatterjee, Arnab K., Yuen, Kwok-Yung, Chanda, Sumit K.
Published in Nature (London) (01.10.2020)
Published in Nature (London) (01.10.2020)
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ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury
Yamaguchi, Tomokazu, Hoshizaki, Midori, Minato, Takafumi, Nirasawa, Satoru, Asaka, Masamitsu N., Niiyama, Mayumi, Imai, Masaki, Uda, Akihiko, Chan, Jasper Fuk-Woo, Takahashi, Saori, An, Jianbo, Saku, Akari, Nukiwa, Ryota, Utsumi, Daichi, Kiso, Maki, Yasuhara, Atsuhiro, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Fujino, Yuji, Motoyama, Satoru, Nagata, Satoshi, Penninger, Josef M., Kamada, Haruhiko, Yuen, Kwok-Yung, Kamitani, Wataru, Maeda, Ken, Kawaoka, Yoshihiro, Yasutomi, Yasuhiro, Imai, Yumiko, Kuba, Keiji
Published in Nature communications (23.11.2021)
Published in Nature communications (23.11.2021)
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SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok
Published in Nature communications (09.05.2022)
Published in Nature communications (09.05.2022)
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Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells
Chu, Hin, Chan, Che-Man, Zhang, Xi, Wang, Yixin, Yuan, Shuofeng, Zhou, Jie, Au-Yeung, Rex Kwok-Him, Sze, Kong-Hung, Yang, Dong, Shuai, Huiping, Hou, Yuxin, Li, Cun, Zhao, Xiaoyu, Poon, Vincent Kwok-Man, Leung, Sze Pui, Yeung, Man-Lung, Yan, Jinghua, Lu, Guangwen, Jin, Dong-Yan, Gao, George Fu, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung
Published in The Journal of biological chemistry (27.07.2018)
Published in The Journal of biological chemistry (27.07.2018)
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Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor
Chan, Jasper Fuk-Woo, Chik, Kenn Ka-Heng, Yuan, Shuofeng, Yip, Cyril Chik-Yan, Zhu, Zheng, Tee, Kah-Meng, Tsang, Jessica Oi-Ling, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lu, Gang, Zhang, Anna Jinxia, Lai, Kin-Kui, Chan, Kwok-Hung, Kao, Richard Yi-Tsun, Yuen, Kwok-Yung
Published in Antiviral research (01.05.2017)
Published in Antiviral research (01.05.2017)
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Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
Yuan, Shuofeng, Yin, Xin, Meng, Xiangzhi, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Riva, Laura, Pache, Lars, Chan, Chris Chun-Yiu, Lai, Pok-Man, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lee, Andrew Chak-Yiu, Matsunaga, Naoko, Pu, Yuan, Yuen, Chun-Kit, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Sheng, Li, Du, Yushen, Xu, Wan, Lau, Chit-Ying, Sit, Ko-Yung, Au, Wing-Kuk, Wang, Runming, Zhang, Yu-Yuan, Tang, Yan-Dong, Clausen, Thomas Mandel, Pihl, Jessica, Oh, Juntaek, Sze, Kong-Hung, Zhang, Anna Jinxia, Chu, Hin, Kok, Kin-Hang, Wang, Dong, Cai, Xue-Hui, Esko, Jeffrey D., Hung, Ivan Fan-Ngai, Li, Ronald Adolphus, Chen, Honglin, Sun, Hongzhe, Jin, Dong-Yan, Sun, Ren, Chanda, Sumit K., Yuen, Kwok-Yung
Published in Nature (London) (20.05.2021)
Published in Nature (London) (20.05.2021)
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Emerging SARS-CoV-2 variants expand species tropism to murines
Shuai, Huiping, Chan, Jasper Fuk-Woo, Yuen, Terrence Tsz-Tai, Yoon, Chaemin, Hu, Jing-Chu, Wen, Lei, Hu, Bingjie, Yang, Dong, Wang, Yixin, Hou, Yuxin, Huang, Xiner, Chai, Yue, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lu, Lu, Zhang, Rui-Qi, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Hu, Ye-Fan, Cai, Jian-Piao, Chan, Kwok-Hung, Zhou, Jie, Sridhar, Siddharth, Zhang, Bao-Zhong, Yuan, Shuofeng, Zhang, Anna Jinxia, Huang, Jian-Dong, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Chu, Hin
Published in EBioMedicine (01.11.2021)
Published in EBioMedicine (01.11.2021)
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Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
Zhou, Jie, Li, Cun, Zhao, Guangyu, Chu, Hin, Wang, Dong, Yan, Helen Hoi-Ning, Poon, Vincent Kwok-Man, Wen, Lei, Wong, Bosco Ho-Yin, Zhao, Xiaoyu, Chiu, Man Chun, Yang, Dong, Wang, Yixin, Au-Yeung, Rex K H, Chan, Ivy Hau-Yee, Sun, Shihui, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Memish, Ziad A, Corman, Victor M, Drosten, Christian, Hung, Ivan Fan-Ngai, Zhou, Yusen, Leung, Suet Yi, Yuen, Kwok-Yung
Published in Science advances (01.11.2017)
Published in Science advances (01.11.2017)
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A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses
Zhao, Hanjun, Zhou, Jie, Zhang, Ke, Chu, Hin, Liu, Dabin, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Leung, Ho-Chuen, Fai, Ng, Lin, Yong-Ping, Zhang, Anna Jin-Xia, Jin, Dong-Yan, Yuen, Kwok-Yung, Zheng, Bo-Jian
Published in Scientific reports (25.02.2016)
Published in Scientific reports (25.02.2016)
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Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies
Zhou, Dongyan, Chan, Jasper Fuk-Woo, Zhou, Biao, Zhou, Runhong, Li, Shuang, Shan, Sisi, Liu, Li, Zhang, Anna Jinxia, Chen, Serena J., Chan, Chris Chung-Sing, Xu, Haoran, Poon, Vincent Kwok-Man, Yuan, Shuofeng, Li, Cun, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Chan, Chun-Yin, Kwan, Ka-Yi, Du, Zhenglong, Lau, Thomas Tsz-Kan, Zhang, Qi, Zhou, Jie, To, Kelvin Kai-Wang, Zhang, Linqi, Ho, David D., Yuen, Kwok-Yung, Chen, Zhiwei
Published in Cell host & microbe (14.04.2021)
Published in Cell host & microbe (14.04.2021)
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A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
Zhou, Biao, Zhou, Runhong, Tang, Bingjie, Chan, Jasper Fuk-Woo, Luo, Mengxiao, Peng, Qiaoli, Yuan, Shuofeng, Liu, Hang, Mok, Bobo Wing-Yee, Chen, Bohao, Wang, Pui, Poon, Vincent Kwok-Man, Chu, Hin, Chan, Chris Chung-Sing, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Au, Ka-Kit, Man, Hiu-On, Lu, Lu, To, Kelvin Kai-Wang, Chen, Honglin, Yuen, Kwok-Yung, Dang, Shangyu, Chen, Zhiwei
Published in Nature communications (23.06.2022)
Published in Nature communications (23.06.2022)
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