The tethered peptide activation mechanism of adhesion GPCRs
Barros-Álvarez, Ximena, Nwokonko, Robert M, Vizurraga, Alexander, Matzov, Donna, He, Feng, Papasergi-Scott, Makaía M, Robertson, Michael J, Panova, Ouliana, Yardeni, Eliane Hadas, Seven, Alpay B, Kwarcinski, Frank E, Su, Hongyu, Peroto, Maria Claudia, Meyerowitz, Justin G, Shalev-Benami, Moran, Tall, Gregory G, Skiniotis, Georgios
Published in Nature (London) (28.04.2022)
Published in Nature (London) (28.04.2022)
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Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms
Papasergi-Scott, Makaía M., Kwarcinski, Frank E., Yu, Maiya, Panova, Ouliana, Ovrutsky, Ann M., Skiniotis, Georgios, Tall, Gregory G.
Published in Structure (London) (04.05.2023)
Published in Structure (London) (04.05.2023)
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A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P‑Loop Conformation
Picado, Alfredo, Chaikuad, Apirat, Wells, Carrow I, Shrestha, Safal, Zuercher, William J, Pickett, Julie E, Kwarcinski, Frank E, Sinha, Parvathi, de Silva, Chandi S, Zutshi, Reena, Liu, Shubin, Kannan, Natarajan, Knapp, Stefan, Drewry, David H, Willson, Timothy M
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity
Kwarcinski, Frank E, Brandvold, Kristoffer R, Phadke, Sameer, Beleh, Omar M, Johnson, Taylor K, Meagher, Jennifer L, Seeliger, Markus A, Stuckey, Jeanne A, Soellner, Matthew B
Published in ACS chemical biology (20.05.2016)
Published in ACS chemical biology (20.05.2016)
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Identification of 4‐Anilinoquin(az)oline as a Cell‐Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype
Asquith, Christopher R. M., Temme, Louisa, East, Michael P., Laitinen, Tuomo, Pickett, Julie, Kwarcinski, Frank E., Sinha, Parvathi, Wells, Carrow I., Johnson, Gary L., Zutshi, Reena, Drewry, David H.
Published in ChemMedChem (20.06.2022)
Published in ChemMedChem (20.06.2022)
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UM-164: A Potent c-Src/p38 Kinase Inhibitor with In Vivo Activity against Triple-Negative Breast Cancer
Gilani, Rabia A, Phadke, Sameer, Bao, Li Wei, Lachacz, Eric J, Dziubinski, Michele L, Brandvold, Kristoffer R, Steffey, Michael E, Kwarcinski, Frank E, Graveel, Carrie R, Kidwell, Kelley M, Merajver, Sofia D, Soellner, Matthew B
Published in Clinical cancer research (15.10.2016)
Published in Clinical cancer research (15.10.2016)
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Retraction: UM-164: A Potent c-Src/p38 Kinase Inhibitor with In Vivo Activity against Triple-Negative Breast Cancer
Gilani, Rabia A, Phadke, Sameer, Bao, Li Wei, Lachacz, Eric J, Dziubinski, Michele L, Brandvold, Kristoffer R, Steffey, Michael E, Kwarcinski, Frank E, Graveel, Carrie R, Kidwell, Kelley M, Merajver, Sofia D, Soellner, Matthew B
Published in Clinical cancer research (01.04.2020)
Published in Clinical cancer research (01.04.2020)
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Irreversible Inhibitors of c‑Src Kinase That Target a Nonconserved Cysteine
Kwarcinski, Frank E, Fox, Christel C, Steffey, Michael E, Soellner, Matthew B
Published in ACS chemical biology (16.11.2012)
Published in ACS chemical biology (16.11.2012)
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Substrate Activity Screening with Kinases: Discovery of Small-Molecule Substrate-Competitive c-Src Inhibitors
Breen, Meghan E., Steffey, Michael E., Lachacz, Eric J., Kwarcinski, Frank E., Fox, Christel C., Soellner, Matthew B.
Published in Angewandte Chemie (International ed.) (01.07.2014)
Published in Angewandte Chemie (International ed.) (01.07.2014)
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Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment Elaboration
Kwarcinski, Frank E, Steffey, Michael E, Fox, Christel C, Soellner, Matthew B
Published in ACS medicinal chemistry letters (13.08.2015)
Published in ACS medicinal chemistry letters (13.08.2015)
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Nano-Structures and Interactions of Alkali Metals within Silica Gel
Dye, James L, Nandi, Partha, Jackson, James E, Lefenfeld, Michael, Bentley, Philip A, Dunyak, Bryan M, Kwarcinski, Frank E, Spencer, Christopher M, Lindman, Thomas N, Lambert, Peter, Jacobson, Peter K, Redko, Mikhail Y
Published in Chemistry of materials (10.05.2011)
Published in Chemistry of materials (10.05.2011)
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Substrate Activity Screening with Kinases: Discovery of Small-Molecule Substrate-Competitive c-Src Inhibitors
Breen, Meghan E., Steffey, Michael E., Lachacz, Eric J., Kwarcinski, Frank E., Fox, Christel C., Soellner, Matthew B.
Published in Angewandte Chemie (01.07.2014)
Published in Angewandte Chemie (01.07.2014)
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Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial Pf GSK3/ Pf PK6 with Activity against Blood Stage Parasites In Vitro
Galal, Kareem A., Truong, Anna, Kwarcinski, Frank, de Silva, Chandi, Avalani, Krisha, Havener, Tammy M., Chirgwin, Michael E., Merten, Eric, Ong, Han Wee, Willis, Caleb, Abdelwaly, Ahmad, Helal, Mohamed A., Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Discovery of potent Plasmodium falciparum protein kinase 6 (PfPK6) inhibitors with a type II inhibitor pharmacophore
Ong, Han Wee, Truong, Anna, Kwarcinski, Frank, de Silva, Chandi, Avalani, Krisha, Havener, Tammy M., Chirgwin, Michael, Galal, Kareem A., Willis, Caleb, Krämer, Andreas, Liu, Shubin, Knapp, Stefan, Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.
Published in European journal of medicinal chemistry (05.03.2023)
Published in European journal of medicinal chemistry (05.03.2023)
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Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro
Galal, Kareem A., Truong, Anna, Kwarcinski, Frank, de Silva, Chandi, Avalani, Krisha, Havener, Tammy M., Chirgwin, Michael E., Merten, Eric, Ong, Han Wee, Willis, Caleb, Abdelwaly, Ahmad, Helal, Mohamed A., Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Characterization of 2,4-Dianilinopyrimidines Against Five P. falciparum Kinases PfARK1, PfARK3, PfNEK3, PfPK9, and PfPKB
Ong, Han Wee, de Silva, Chandi, Avalani, Krisha, Kwarcinski, Frank, Mansfield, Christopher R., Chirgwin, Michael, Truong, Anna, Derbyshire, Emily R., Zutshi, Reena, Drewry, David H.
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
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Identification of 4-anilino-quin(az)oline as a cell active Protein Kinase Novel 3 (PKN3) inhibitor chemotype
Asquith, Christopher R. M., Temme, Louisa, East, Michael P., Laitinen, Tuomo, Pickett, Julie, Kwarcinski, Frank E., Sinha, Parvathi, Wells, Carrow I., Johnson, Gary L., Zutshi, Reena, Drewry, David H.
Published in ChemMedChem (09.05.2022)
Published in ChemMedChem (09.05.2022)
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Journal Article
UM-164: A Potent c-Srcp38 Kinase Inhibitor with In Vivo Activity against Triple-Negative Breast Cancer
Gilani, Rabia A, Phadke, Sameer, Bao, Li Wei, Lachacz, Eric J, Dziubinski, Michele L, Brandvold, Kristoffer R, Steffey, Michael E, Kwarcinski, Frank E, Graveel, Carrie R, Kidwell, Kelley M, Merajver, Sofia D, Soellner, Matthew B
Published in Clinical cancer research (15.10.2016)
Published in Clinical cancer research (15.10.2016)
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