Longitudinal single-cell RNA sequencing of patient-derived primary cells reveals drug-induced infidelity in stem cell hierarchy
Sharma, Ankur, Cao, Elaine Yiqun, Kumar, Vibhor, Zhang, Xiaoqian, Leong, Hui Sun, Wong, Angeline Mei Lin, Ramakrishnan, Neeraja, Hakimullah, Muhammad, Teo, Hui Min Vivian, Chong, Fui Teen, Chia, Shumei, Thangavelu, Matan Thangavelu, Kwang, Xue Lin, Gupta, Ruta, Clark, Jonathan R, Periyasamy, Giridharan, Iyer, N Gopalakrishna, DasGupta, Ramanuj
Published in Nature communications (22.11.2018)
Published in Nature communications (22.11.2018)
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Journal Article
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing
Nahar, Rahul, Zhai, Weiwei, Zhang, Tong, Takano, Angela, Khng, Alexis J, Lee, Yin Yeng, Liu, Xingliang, Lim, Chong Hee, Koh, Tina P T, Aung, Zaw Win, Lim, Tony Kiat Hon, Veeravalli, Lavanya, Yuan, Ju, Teo, Audrey S M, Chan, Cheryl X, Poh, Huay Mei, Chua, Ivan M L, Liew, Audrey Ann, Lau, Dawn Ping Xi, Kwang, Xue Lin, Toh, Chee Keong, Lim, Wan-Teck, Lim, Bing, Tam, Wai Leong, Tan, Eng-Huat, Hillmer, Axel M, Tan, Daniel S W
Published in Nature communications (15.01.2018)
Published in Nature communications (15.01.2018)
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Journal Article
Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time
Chia, Shumei, Low, Joo-Leng, Zhang, Xiaoqian, Kwang, Xue-Lin, Chong, Fui-Teen, Sharma, Ankur, Bertrand, Denis, Toh, Shen Yon, Leong, Hui-Sun, Thangavelu, Matan T, Hwang, Jacqueline S G, Lim, Kok-Hing, Skanthakumar, Thakshayeni, Tan, Hiang-Khoon, Su, Yan, Hui Choo, Siang, Hentze, Hannes, Tan, Iain B H, Lezhava, Alexander, Tan, Patrick, Tan, Daniel S W, Periyasamy, Giridharan, Koh, Judice L Y, Gopalakrishna Iyer, N, DasGupta, Ramanuj
Published in Nature communications (05.09.2017)
Published in Nature communications (05.09.2017)
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Journal Article
Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer
Ho, Nicholas Ching Wei, Yap, Josephine Yu Yan, Zhao, Zixuan, Wang, Yunyun, Fernando, Kanishka, Li, Constance H, Kwang, Xue Lin, Quah, Hong Sheng, Arcinas, Camille, Iyer, N. Gopalakrishna, Fong, Eliza Li Shan
Published in Advanced science (01.05.2024)
Published in Advanced science (01.05.2024)
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Journal Article
A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC)
Low, Joo-Leng, Lau, Dawn Pingxi, Zhang, Xiaoqian, Kwang, Xue-Lin, Rohatgi, Neha, Chan, Jane Vin, Chong, Fui-Teen, Wong, Stephen Qi Rong, Leong, Hui-Sun, Thangavelu, Matan Thangavelu, Rikka, Shivaji, Skanderup, Anders Martin Jacobsen, Tan, Daniel Shao Weng, Periyasamy, Giridharan, Koh, Judice Lie Yong, Iyer, N Gopalakrishna, DasGupta, Ramanuj
Published in EBioMedicine (01.02.2021)
Published in EBioMedicine (01.02.2021)
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Journal Article
Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma
Tan, Daniel S W, Chong, Fui Teen, Leong, Hui Sun, Toh, Shen Yon, Lau, Dawn P, Kwang, Xue Lin, Zhang, Xiaoqian, Sundaram, Gopinath M, Tan, Gek San, Chang, Mei Mei, Chua, Boon Tin, Lim, Wan Teck, Tan, Eng Huat, Ang, Mei Kim, Lim, Tony K H, Sampath, Prabha, Chowbay, Balram, Skanderup, Anders J, DasGupta, Ramanuj, Iyer, N Gopalakrishna
Published in Nature medicine (01.10.2017)
Published in Nature medicine (01.10.2017)
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Journal Article
Clonal MET Amplification as a Determinant of Tyrosine Kinase Inhibitor Resistance in Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer
Lai, Gillianne G Y, Lim, Tse Hui, Lim, John, Liew, Perry J R, Kwang, Xue Lin, Nahar, Rahul, Aung, Zaw Win, Takano, Angela, Lee, Yin Yeng, Lau, Dawn P X, Tan, Gek San, Tan, Sze Huey, Tan, Wan Ling, Ang, Mei-Kim, Toh, Chee Keong, Tan, Bien Soo, Devanand, Anantham, Too, Chow Wei, Gogna, Apoorva, Ong, Boon Hean, Koh, Tina P T, Kanesvaran, Ravindran, Ng, Quan Sing, Jain, Amit, Rajasekaran, Tanujaa, Yuan, Ju, Lim, Tony Kiat Hon, Lim, Alvin S T, Hillmer, Axel M, Lim, Wan Teck, Iyer, N Gopalakrishna, Tam, Wai Leong, Zhai, Weiwei, Tan, Eng-Huat, Tan, Daniel S W
Published in Journal of clinical oncology (10.04.2019)
Published in Journal of clinical oncology (10.04.2019)
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Journal Article
Corrigendum to ‘A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC)’
Low, Joo-Leng, Lau, Dawn Pingxi, Zhang, Xiaoqian, Kwang, Xue-Lin, Rohatgi, Neha, Chan, Jane Vin, Chong, Fui-Teen, Wong, Stephen Qi Rong, Leong, Hui-Sun, Thangavelu, Matan Thangavelu, Rikka, Shivaji, Skanderup, Anders Martin Jacobsen, Tan, Daniel Shao Weng, Periyasamy, Giridharan, Koh, Judice Lie Yong, Iyer, N Gopalakrishna, DasGupta, Ramanuj
Published in EBioMedicine (01.04.2021)
Published in EBioMedicine (01.04.2021)
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Journal Article
Therapeutic application of extracellular vesicular EGFR isoform D as a co-drug to target squamous cell cancers with tyrosine kinase inhibitors
Toh, Shen Yon, Leong, Hui Sun, Chong, Fui Teen, Rodrigues-Junior, Dorival Mendes, Ren, Meng Jie, Kwang, Xue Lin, Lau, Dawn P.X., Lee, Po-Hsien, Vettore, Andre Luiz, Teh, Bin Tean, Tan, Daniel S.W., Iyer, N. Gopalakrishna
Published in Developmental cell (19.08.2024)
Published in Developmental cell (19.08.2024)
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Journal Article
Abstract 2591: Role of EGFR-AS1 lncRNA in growth factor addiction and treatment response in squamous cell cancers
Tan, Daniel SW, Chong, Fui-Teen, Leong, Hui-Sun, Toh, Shen Yon, Lau, Dawn P., Kwang, Xue Lin, Zhang, Xiaoqian, Tan, Gek San, Skanderup, Anders J., Lim, Tony KH, Dasgupta, Ramanuj, Iyer, N Gopalakrishna
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Pairing a prognostic target with potential therapeutic strategy for head and neck cancer
Lek, Sze Min, Li, Ke, Tan, Qiu Xuan, Shannon, Nicholas B., Ng, Wai Har, Hendrikson, Josephine, Tan, Joey W.S., Lim, Hui Jun, Chen, Yudong, Koh, Kelvin K.N., Skanthakumar, Thakshayeni, Kwang, Xue Lin, Chong, Fui Teen, Leong, Hui Sun, Tay, Gerald, Putri, Natascha Ekawati, Lim, Tony Kiat Hon, Hwang, Jacqueline S.G., Ang, Mei Kim, Tan, Daniel S.W., Tan, Ngian Chye, Tan, Hiang Khoon, Kon, Oi Lian, Soo, Khee Chee, Iyer, N. Gopalakrishna, Ong, Chin-Ann J.
Published in Oral oncology (01.12.2020)
Published in Oral oncology (01.12.2020)
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Journal Article
Abstract 2109: Clonal heterogeneity of EGFR TKI-resistant NSCLC revealed through single-cell dilutional cloning and high-throughput functional screens
Lau, Dawn Pingxi, Rikka, Shivaji, Leong, Hui Sun, Tan, Gek San, Christodoulou, Eleni G, Krisna, Sai Sakktee, Toh, Shen Yon, Kwang, Xue Lin, Chong, Fui Teen, Liew, Audrey Ann, Lim, Tony Kiat Hon, Ramanuj, DasGupta, Iyer, N Gopalakrishna, Tan, Daniel Shao-Weng
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Single-cell RNA-seq unveils divergent modes of chemoresistance in squamous cell carcinoma
Sharma, Ankur, Kumar, Vibhor, Cao, Elaine Yiqun, Leong, Hui Sun, Hakimullah, Muhammad, Ramakrishnan, Neeraja, Zhang, Xiaoqian, Chong, Fui Teen, Chia, Shumei, Thangavelu, Matan Thangavelu, Wong, Angeline Mei Lin, Kwang, Xue Lin, Tan, Daniel Shao-Weng, Periyasamy, Giridharan, Gopalakrishna Iyer, N., DasGupta, Ramanuj
Published in Mechanisms of development (01.07.2017)
Published in Mechanisms of development (01.07.2017)
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