Selexipag: An Oral and Selective IP Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension
Asaki, Tetsuo, Kuwano, Keiichi, Morrison, Keith, Gatfield, John, Hamamoto, Taisuke, Clozel, Martine
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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A Long-Acting and Highly Selective Prostacyclin Receptor Agonist Prodrug, 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), Ameliorates Rat Pulmonary Hypertension with Unique Relaxant Responses of Its Active Form, {4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic Acid (MRE-269), on Rat Pulmonary Artery
Kuwano, Keiichi, Hashino, Asami, Noda, Kumiko, Kosugi, Keiji, Kuwabara, Kenji
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2008)
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A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries
Fuchikami, Chiaki, Murakami, Kohji, Tajima, Koyuki, Homan, Junko, Kosugi, Keiji, Kuramoto, Kazuya, Oka, Michiko, Kuwano, Keiichi
Published in European journal of pharmacology (15.01.2017)
Published in European journal of pharmacology (15.01.2017)
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Antiproliferative effect of selexipag active metabolite MRE‐269 on pulmonary arterial smooth muscle cells from patients with chronic thromboembolic pulmonary hypertension
Kuramoto, Kazuya, Ogawa, Aiko, Kiyama, Kazuko, Matsubara, Hiromi, Ohno, Yuji, Fuchikami, Chiaki, Hayashi, Kyota, Kosugi, Keiji, Kuwano, Keiichi
Published in Pulmonary circulation (01.04.2023)
Published in Pulmonary circulation (01.04.2023)
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2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), an Orally Available and Long-Acting Prostacyclin Receptor Agonist Prodrug
Kuwano, Keiichi, Hashino, Asami, Asaki, Tetsuo, Hamamoto, Taisuke, Yamada, Tetsuhiro, Okubo, Kaori, Kuwabara, Kenji
Published in The Journal of pharmacology and experimental therapeutics (01.09.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2007)
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Journal Article
Structure–activity relationship study on the 6-membered heteroaromatic ring system of diphenylpyrazine-type prostacyclin receptor agonists
Asaki, Tetsuo, Hamamoto, Taisuke, Sugiyama, Yukiteru, Kuwano, Keiichi, Kuwabara, Kenji, Niwa, Tomoko
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Journal Article
2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug
Kuwano, Keiichi, Hashino, Asami, Asaki, Tetsuo, Hamamoto, Taisuke, Yamada, Tetsuhiro, Okubo, Kaori, Kuwabara, Kenji
Published in The Journal of pharmacology and experimental therapeutics (01.09.2007)
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Published in The Journal of pharmacology and experimental therapeutics (01.09.2007)
Journal Article