Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia
Kuusanmäki, Heikki, Leppä, Aino-Maija, Pölönen, Petri, Kontro, Mika, Dufva, Olli, Deb, Debashish, Yadav, Bhagwan, Brück, Oscar, Kumar, Ashwini, Everaus, Hele, Gjertsen, Bjørn T, Heinäniemi, Merja, Porkka, Kimmo, Mustjoki, Satu, Heckman, Caroline A
Published in Haematologica (Roma) (01.03.2020)
Published in Haematologica (Roma) (01.03.2020)
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Identification of novel regulators of STAT3 activity
Parri, Elina, Kuusanmäki, Heikki, van Adrichem, Arjan J, Kaustio, Meri, Wennerberg, Krister
Published in PloS one (31.03.2020)
Published in PloS one (31.03.2020)
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Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, Heikki, Dufva, Olli, Vähä-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Adnan-Awad, Shady, Mancebo-Pérez, Cristina, Saad, Joseph, Miettinen, Juho, Javarappa, Komal K., Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Theilgaard-Mönch, Kim, Wartiovaara-Kautto, Ulla, Keränen, Mikko, Porkka, Kimmo, Konopleva, Marina, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu
Published in Blood (30.03.2023)
Published in Blood (30.03.2023)
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Targeting CD33+ acute myeloid leukemia with GLK-33, a lintuzumab-auristatin conjugate with a wide therapeutic window
Satomaa, Tero, Pynnönen, Henna, Aitio, Olli, Hiltunen, Jukka O, Pitkänen, Virve, Lähteenmäki, Tuula, Kotiranta, Titta, Heiskanen, Annamari, Hänninen, Anna-Liisa, Niemelä, Ritva, Helin, Jari, Kuusanmaki, Heikki, Vänttinen, Ida, Rathod, Ramji, Nieminen, Anni I, Yatkin, Emrah, Heckman, Caroline A, Kontro, Mika, Saarinen, Juhani
Published in Molecular cancer therapeutics (01.08.2024)
Published in Molecular cancer therapeutics (01.08.2024)
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Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing
Majumder, Muntasir Mamun, Silvennoinen, Raija, Anttila, Pekka, Tamborero, David, Eldfors, Samuli, Yadav, Bhagwan, Karjalainen, Riikka, Kuusanmäki, Heikki, Lievonen, Juha, Parsons, Alun, Suvela, Minna, Jantunen, Esa, Porkka, Kimmo, Heckman, Caroline A
Published in Oncotarget (22.08.2017)
Published in Oncotarget (22.08.2017)
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Endogenous and combination retinoids are active in myelomonocytic leukemias
Di Martino, Orsola, Niu, Haixia, Hadwiger, Gayla, Kuusanmaki, Heikki, Ferris, Margaret A, Vu, Anh, Beales, Jeremy, Wagner, Carl, Menéndez-Gutiérrez, María P, Ricote, Mercedes, Heckman, Caroline, Welch, John S
Published in Haematologica (Roma) (01.04.2021)
Published in Haematologica (Roma) (01.04.2021)
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Selective drug combination vulnerabilities in STAT3- and TP53-mutant malignant NK cells
Parri, Elina, Kuusanmäki, Heikki, Bulanova, Daria, Mustjoki, Satu, Wennerberg, Krister
Published in Blood advances (13.04.2021)
Published in Blood advances (13.04.2021)
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Standardized assays to monitor drug sensitivity in hematologic cancers
Ayuda-Durán, Pilar, Hermansen, Johanne U, Giliberto, Mariaserena, Yin, Yanping, Hanes, Robert, Gordon, Sandra, Kuusanmäki, Heikki, Brodersen, Andrea M, Andersen, Aram N, Taskén, Kjetil, Wennerberg, Krister, Enserink, Jorrit M, Skånland, Sigrid S
Published in Cell death discovery (01.12.2023)
Published in Cell death discovery (01.12.2023)
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Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling
Kuusanmäki, Heikki, Dufva, Olli, Parri, Elina, van Adrichem, Arjan J, Rajala, Hanna, Majumder, Muntasir M, Yadav, Bhagwan, Parsons, Alun, Chan, Wing C, Wennerberg, Krister, Mustjoki, Satu, Heckman, Caroline A
Published in Oncotarget (14.11.2017)
Published in Oncotarget (14.11.2017)
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Patient-tailored design for selective co-inhibition of leukemic cell subpopulations
Ianevski, Aleksandr, Lahtela, Jenni, Javarappa, Komal K, Sergeev, Philipp, Ghimire, Bishwa R, Gautam, Prson, Vähä-Koskela, Markus, Turunen, Laura, Linnavirta, Nora, Kuusanmäki, Heikki, Kontro, Mika, Porkka, Kimmo, Heckman, Caroline A, Mattila, Pirkko, Wennerberg, Krister, Giri, Anil K, Aittokallio, Tero
Published in Science advances (19.02.2021)
Published in Science advances (19.02.2021)
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Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry
Heikkinen, Tuomas, Kämpjärvi, Kati, Keskitalo, Salla, von Nandelstadh, Pernilla, Liu, Xiaonan, Rantanen, Ville, Pitkänen, Esa, Kinnunen, Matias, Kuusanmäki, Heikki, Kontro, Mika, Turunen, Mikko, Mäkinen, Netta, Taipale, Jussi, Heckman, Caroline, Lehti, Kaisa, Mustjoki, Satu, Varjosalo, Markku, Vahteristo, Pia
Published in Human mutation (01.03.2017)
Published in Human mutation (01.03.2017)
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Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors
Pietarinen, Paavo O, Eide, Christopher A, Ayuda-Durán, Pilar, Potdar, Swapnil, Kuusanmäki, Heikki, Andersson, Emma I, Mpindi, John P, Pemovska, Tea, Kontro, Mika, Heckman, Caroline A, Kallioniemi, Olli, Wennerberg, Krister, Hjorth-Hansen, Henrik, Druker, Brian J, Enserink, Jorrit M, Tyner, Jeffrey W, Mustjoki, Satu, Porkka, Kimmo
Published in Oncotarget (04.04.2017)
Published in Oncotarget (04.04.2017)
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Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
Koskela, Hanna L.M, Eldfors, Samuli, Ellonen, Pekka, van Adrichem, Arjan J, Kuusanmäki, Heikki, Andersson, Emma I, Lagström, Sonja, Clemente, Michael J, Olson, Thomas, Jalkanen, Sari E, Majumder, Muntasir Mamun, Almusa, Henrikki, Edgren, Henrik, Lepistö, Maija, Mattila, Pirkko, Guinta, Kathryn, Koistinen, Pirjo, Kuittinen, Taru, Penttinen, Kati, Parsons, Alun, Knowles, Jonathan, Saarela, Janna, Wennerberg, Krister, Kallioniemi, Olli, Porkka, Kimmo, Loughran, Thomas P, Heckman, Caroline A, Maciejewski, Jaroslaw P, Mustjoki, Satu
Published in The New England journal of medicine (17.05.2012)
Published in The New England journal of medicine (17.05.2012)
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Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
Dufva, Olli, Kankainen, Matti, Kelkka, Tiina, Sekiguchi, Nodoka, Awad, Shady Adnan, Eldfors, Samuli, Yadav, Bhagwan, Kuusanmäki, Heikki, Malani, Disha, Andersson, Emma I, Pietarinen, Paavo, Saikko, Leena, Kovanen, Panu E, Ojala, Teija, Lee, Dean A, Loughran, Jr, Thomas P, Nakazawa, Hideyuki, Suzumiya, Junji, Suzuki, Ritsuro, Ko, Young Hyeh, Kim, Won Seog, Chuang, Shih-Sung, Aittokallio, Tero, Chan, Wing C, Ohshima, Koichi, Ishida, Fumihiro, Mustjoki, Satu
Published in Nature communications (19.04.2018)
Published in Nature communications (19.04.2018)
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Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
Rajala, Hanna L.M., Eldfors, Samuli, Kuusanmäki, Heikki, van Adrichem, Arjan J., Olson, Thomas, Lagström, Sonja, Andersson, Emma I., Jerez, Andres, Clemente, Michael J., Yan, Yiyi, Zhang, Dan, Awwad, Andy, Ellonen, Pekka, Kallioniemi, Olli, Wennerberg, Krister, Porkka, Kimmo, Maciejewski, Jaroslaw P., Loughran, Thomas P., Heckman, Caroline, Mustjoki, Satu
Published in Blood (30.05.2013)
Published in Blood (30.05.2013)
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Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia
Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Ranta, Amanda, Huuhtanen, Jani, Suvela, Minna, Parsons, Alun, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E L, Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Västrik, Imre, Dufva, Olli, Siitonen, Sanna, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A, Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika
Published in Haematologica (Roma) (01.07.2023)
Published in Haematologica (Roma) (01.07.2023)
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Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia
Malani, Disha, Kumar, Ashwini, Brück, Oscar, Kontro, Mika, Yadav, Bhagwan, Hellesøy, Monica, Kuusanmäki, Heikki, Dufva, Olli, Kankainen, Matti, Eldfors, Samuli, Potdar, Swapnil, Saarela, Jani, Turunen, Laura, Parsons, Alun, Västrik, Imre, Kivinen, Katja, Saarela, Janna, Räty, Riikka, Lehto, Minna, Wolf, Maija, Gjertsen, Bjorn Tore, Mustjoki, Satu, Aittokallio, Tero, Wennerberg, Krister, Heckman, Caroline A, Kallioniemi, Olli, Porkka, Kimmo
Published in Cancer discovery (01.02.2022)
Published in Cancer discovery (01.02.2022)
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Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
Haapaniemi, Emma M., Kaustio, Meri, Rajala, Hanna L.M., van Adrichem, Arjan J., Kainulainen, Leena, Glumoff, Virpi, Doffinger, Rainer, Kuusanmäki, Heikki, Heiskanen-Kosma, Tarja, Trotta, Luca, Chiang, Samuel, Kulmala, Petri, Eldfors, Samuli, Katainen, Riku, Siitonen, Sanna, Karjalainen-Lindsberg, Marja-Liisa, Kovanen, Panu E., Otonkoski, Timo, Porkka, Kimmo, Heiskanen, Kaarina, Hänninen, Arno, Bryceson, Yenan T., Uusitalo-Seppälä, Raija, Saarela, Janna, Seppänen, Mikko, Mustjoki, Satu, Kere, Juha
Published in Blood (22.01.2015)
Published in Blood (22.01.2015)
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Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia
White, Brian S, Khan, Suleiman A, Mason, Mike J, Ammad-Ud-Din, Muhammad, Potdar, Swapnil, Malani, Disha, Kuusanmäki, Heikki, Druker, Brian J, Heckman, Caroline, Kallioniemi, Olli, Kurtz, Stephen E, Porkka, Kimmo, Tognon, Cristina E, Tyner, Jeffrey W, Aittokallio, Tero, Wennerberg, Krister, Guinney, Justin
Published in NPJ precision oncology (23.07.2021)
Published in NPJ precision oncology (23.07.2021)
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P409: BCL‐2/BCL‐XL INHIBITION INDUCES APOPTOSIS AND CIRCUMVENTS VENETOCLAX RESISTANCE IN TP53‐MUTATED ACUTE MYELOID LEUKEMIA
Vänttinen, Ida, Kytölä, Sari, Dufva, Olli, Hellesøy, Monica, Gullaksen, Stein‐Erik, Ruokoranta, Tanja, Brück, Oscar, Siitonen, Sanna, Ettala, Pia, Pyörälä, Marja, Rimpilainen, Johanna, Siitonen, Timo, Tore Gjertsen, Bjorn, Heckman, Caroline, Kuusanmäki, Heikki, Kontro, Mika
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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