Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
Juni, Rio P., PhD, Kuster, Diederik W.D., PhD, Goebel, Max, MSc, Helmes, Michiel, PhD, Musters, René J.P., PhD, van der Velden, Jolanda, PhD, Koolwijk, Pieter, PhD, Paulus, Walter J., MD, PhD, van Hinsbergh, Victor W.M., PhD
Published in JACC. Basic to translational science (01.09.2019)
Published in JACC. Basic to translational science (01.09.2019)
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Journal Article
Sex-specific cardiac remodeling in early and advanced stages of hypertrophic cardiomyopathy
Nijenkamp, Louise L A M, Bollen, Ilse A E, Niessen, Hans W M, Dos Remedios, Cris G, Michels, Michelle, Poggesi, Corrado, Ho, Carolyn Y, Kuster, Diederik W D, van der Velden, Jolanda
Published in PloS one (05.05.2020)
Published in PloS one (05.05.2020)
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Journal Article
Contribution of Impaired Parasympathetic Activity to Right Ventricular Dysfunction and Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension
da Silva Gonçalves Bós, Denielli, Van Der Bruggen, Cathelijne E E, Kurakula, Kondababu, Sun, Xiao-Qing, Casali, Karina R, Casali, Adenauer G, Rol, Nina, Szulcek, Robert, dos Remedios, Cris, Guignabert, Christophe, Tu, Ly, Dorfmüller, Peter, Humbert, Marc, Wijnker, Paul J.M, Kuster, Diederik W.D, van der Velden, Jolanda, Goumans, Marie-José, Bogaard, Harm-Jan, Vonk-Noordegraaf, Anton, de Man, Frances S, Handoko, M Louis
Published in Circulation (New York, N.Y.) (27.02.2018)
Published in Circulation (New York, N.Y.) (27.02.2018)
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Journal Article
Translating myosin-binding protein C and titin abnormalities to whole-heart function using a novel calcium-contraction coupling model
Arts, Theo, Lyon, Aurore, Delhaas, Tammo, Kuster, Diederik W.D., van der Velden, Jolanda, Lumens, Joost
Published in Journal of molecular and cellular cardiology (01.05.2024)
Published in Journal of molecular and cellular cardiology (01.05.2024)
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Journal Article
Empagliflozin restores chronic kidney disease–induced impairment of endothelial regulation of cardiomyocyte relaxation and contraction
Juni, Rio P., Al-Shama, Rushd, Kuster, Diederik W.D., van der Velden, Jolanda, Hamer, Henrike M., Vervloet, Marc G., Eringa, Etto C., Koolwijk, Pieter, van Hinsbergh, Victor W.M.
Published in Kidney international (01.05.2021)
Published in Kidney international (01.05.2021)
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Journal Article
Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling
VuckoviÄ, Sofija, Dinani, Rafeeh, Nollet, Edgar E, Kuster, Diederik W. D, Buikema, Jan Willem, Houtkooper, Riekelt H, Nabben, Miranda, van der Velden, Jolanda, Goversen, Birgit
Published in Stem cell research & therapy (23.07.2022)
Published in Stem cell research & therapy (23.07.2022)
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Journal Article
Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations
Sequeira, Vasco, Wijnker, Paul J.M, Nijenkamp, Louise L.A.M, Kuster, Diederik W.D, Najafi, Aref, Witjas-Paalberends, E Rosalie, Regan, Jessica A, Boontje, Nicky, ten Cate, Folkert J, Germans, Tjeerd, Carrier, Lucie, Sadayappan, Sakthivel, van Slegtenhorst, Marjon A, Zaremba, Ruud, Foster, D Brian, Murphy, Anne M, Poggesi, Corrado, dos Remedios, Cris, Stienen, Ger J.M, Ho, Carolyn Y, Michels, Michelle, van der Velden, Jolanda
Published in Circulation research (24.05.2013)
Published in Circulation research (24.05.2013)
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Journal Article
Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration
Nollet, Edgar E, Duursma, Inez, Rozenbaum, Anastasiya, Eggelbusch, Moritz, Wüst, Rob C I, Schoonvelde, Stephan A C, Michels, Michelle, Jansen, Mark, van der Wel, Nicole N, Bedi, Kenneth C, Margulies, Kenneth B, Nirschl, Jeff, Kuster, Diederik W D, van der Velden, Jolanda
Published in European heart journal (01.04.2023)
Published in European heart journal (01.04.2023)
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Journal Article
The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes
Montañés-Agudo, Pablo, Aufiero, Simona, Schepers, Eva N, van der Made, Ingeborg, Cócera-Ortega, Lucia, Ernault, Auriane C, Richard, Stéphane, Kuster, Diederik W D, Christoffels, Vincent M, Pinto, Yigal M, Creemers, Esther E
Published in Cardiovascular research (22.05.2023)
Published in Cardiovascular research (22.05.2023)
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Journal Article
Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium–glucose cotransporter 2 inhibitors
Wijnker, Paul J M, Dinani, Rafeeh, van der Laan, Nico C, Algül, Sila, Knollmann, Bjorn C, Verkerk, Arie O, Remme, Carol Ann, Zuurbier, Coert J, Kuster, Diederik W D, van der Velden, Jolanda
Published in Cardiovascular research (14.03.2024)
Published in Cardiovascular research (14.03.2024)
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Journal Article
The microtubule signature in cardiac disease: etiology, disease stage, and age dependency
Algül, Sıla, Dorsch, Larissa M., Sorop, Oana, Vink, Aryan, Michels, Michelle, dos Remedios, Cristobal G., Dalinghaus, Michiel, Merkus, Daphne, Duncker, Dirk J., Kuster, Diederik W. D., van der Velden, Jolanda
Published in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology (01.10.2023)
Published in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology (01.10.2023)
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Journal Article
Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy
Schuldt, Maike, Pei, Jiayi, Harakalova, Magdalena, Dorsch, Larissa M., Schlossarek, Saskia, Mokry, Michal, Knol, Jaco C., Pham, Thang V., Schelfhorst, Tim, Piersma, Sander R., dos Remedios, Cris, Dalinghaus, Michiel, Michels, Michelle, Asselbergs, Folkert W., Moutin, Marie-Jo, Carrier, Lucie, Jimenez, Connie R., van der Velden, Jolanda, Kuster, Diederik W.D.
Published in Circulation. Heart failure (01.01.2021)
Published in Circulation. Heart failure (01.01.2021)
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Journal Article
EGFR/IGF1R Signaling Modulates Relaxation in Hypertrophic Cardiomyopathy
Algül, Sila, Schuldt, Maike, Manders, Emmy, Jansen, Valentijn, Schlossarek, Saskia, de Goeij-de Haas, Richard, Henneman, Alex A., Piersma, Sander R., Jimenez, Connie R., Michels, Michelle, Carrier, Lucie, Helmes, Michiel, van der Velden, Jolanda, Kuster, Diederik W.D.
Published in Circulation research (18.08.2023)
Published in Circulation research (18.08.2023)
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Journal Article
Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy
Wehrens, Martijn, de Leeuw, Anne E, Wright-Clark, Maya, Eding, Joep E C, Boogerd, Cornelis J, Molenaar, Bas, van der Kraak, Petra H, Kuster, Diederik W D, van der Velden, Jolanda, Michels, Michelle, Vink, Aryan, van Rooij, Eva
Published in Cell reports (Cambridge) (10.05.2022)
Published in Cell reports (Cambridge) (10.05.2022)
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Journal Article
Characterization of heterozygous and homozygous mouse models with the most common hypertrophic cardiomyopathy mutation MYBPC3c.2373InsG in the Netherlands
Hilderink, Sarah, Schuldt, Maike, Goebel, Max, Jansen, Valentijn J, Manders, Emmy, Moorman, Stan, Dorsch, Larissa M, van Steenbeek, Frank G, van der Velden, Jolanda, Kuster, Diederik W D
Published in Journal of molecular and cellular cardiology (01.12.2023)
Published in Journal of molecular and cellular cardiology (01.12.2023)
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Journal Article
DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters
Stege, Nienke M, Eijgenraam, Tim R, Oliveira Nunes Teixeira, Vivian, Feringa, Anna M, Schouten, Elisabeth M, Kuster, Diederik W D, van der Velden, Jolanda, Wolters, Anouk H G, Giepmans, Ben N G, Makarewich, Catherine A, Bassel-Duby, Rhonda, Olson, Eric N, de Boer, Rudolf A, Silljé, Herman H W
Published in Circulation research (08.12.2023)
Published in Circulation research (08.12.2023)
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Journal Article
Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes
Schuldt, Maike, Johnston, Jamie R., He, Huan, Huurman, Roy, Pei, Jiayi, Harakalova, Magdalena, Poggesi, Corrado, Michels, Michelle, Kuster, Diederik W.D., Pinto, Jose R., van der Velden, Jolanda
Published in Journal of molecular and cellular cardiology (01.01.2021)
Published in Journal of molecular and cellular cardiology (01.01.2021)
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Journal Article