Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models
Singh Mali, Raghuveer, Zhang, Qi, DeFilippis, Rosa Anna, Cavazos, Antonio, Kuruvilla, Vinitha Mary, Raman, Jayant, Mody, Vidhi, Choo, Edna F, Dail, Monique, Shah, Neil P, Konopleva, Marina, Sampath, Deepak, Lasater, Elisabeth A
Published in Haematologica (Roma) (01.04.2021)
Published in Haematologica (Roma) (01.04.2021)
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Journal Article
Venetoclax Synergizes with IMGN632, a Novel CD123-Targeting Antibody Conjugated to a DNA Alkylating Payload, By Suppressing DNA Damage Response and Potentiating Apoptosis in Acute Myeloid Leukemia in Vitro Models
Skwarska, Anna, Kuruvilla, Vinitha Mary, Zhang, Qi, Chaudhry, Sovira, Daver, Naval, Watkins, Krystal, Sloss, Callum Mortimer, Zweidler-McKay, Patrick A., Sampath, Deepa, Konopleva, Marina Y.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Combining IMGN632, a Novel CD123-Targeting Antibody Drug Conjugate with Azacitidine and Venetoclax Facilitates Apoptosis in Vitro and Prolongs Survival In Vivo in AML Models
Kuruvilla, Vinitha Mary, Zhang, Qi, Daver, Naval, Watkins, Krystal, Sloss, Callum M, Zweidler-McKay, Patrick A, Romanelli, Angela, Konopleva, Marina
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
“Triple” Combination of Targeting Methyltransferase, BCL-2 and PD-1 Facilitates Therapeutic Responses in Acute Myeloid Leukemia (AML)
Zeng, Zhihong, Herbrich, Shelley, Cai, Tianyu, Cavazos, Antonio, Manzella, Taylor, Ma, Helen, Kuruvilla, Vinitha Mary, Hayes, Kala, Matthews, Jairo A., DiNardo, Courtney D., Daver, Naval, Konopleva, Marina
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Dual Targeting of Mitochondrial Vulnerability Using Complex I Inhibitor Iacs-010759 with Bcl-2 Inhibitor Venetoclax and Azacitidine in Pre-Clinical Acute Myeloid Leukemia (AML) Models
Zhang, Qi, Han, Lina, Lodi, Alessia, Weng, Connie, Kuruvilla, Vinitha Mary, Cavazos, Antonio, Ma, Helen, Maiti, Abhishek, Tabe, Yoko, Marszalek, Joseph R, Tiziani, Stefano, Konopleva, Marina
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism
Baran, Natalia, Han, Lina, Stuani, Lucille, Cavazos, Antonio, Cooper, Laurie, Ramage, Cassandra L., Kuruvilla, Vinitha MARY, Zhang, Qi, Sabtier, Marie, Boet, Emeline, Gay, Jason P, Feng, Ninping, Battula, Venkata Lokesh, Chu-Van, Emeline, Castelli, Florence, Carroll, Martin, Konoplev, Sergej Naumovich, Thakral, Beenu, Daver, Naval, Marszalek, Joseph R, Ge, Yubin, Andreeff, Michael, Sarry, Jean-Emmanuel, Konopleva, Marina Y.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Inhibiting Mitochondria Function By Bcl-2 Inhibitor Venetoclax and Complex I Inhibitor Iacs-010759 Eliminate Leukemia Cells in Pre-Clinical AML Models
Zhang, Qi, Lodi, Alessia, Sweeney, Shannon Renee, Han, Lina, Cai, Tianyu, Kuruvilla, Vinitha Mary, Cavazos, Antonio, Ma, Helen, Tabe, Yoko, Marszalek, Joseph R, Tiziani, Stefano, Konopleva, Marina Y
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
IMGN632, a CD123-Alkylating ADC Bearing a DNA-Alkylating IGN Payload, Combines Effectively with Azacitidine and Venetoclax In Vivo, Prolonging Survival in Preclinical Models of Human Acute Myeloid Leukemia (AML)
Kuruvilla, Vinitha Mary, McCarthy, Rebecca, Zhang, Qi, Sloss, Callum M., Zweidler-McKay, Patrick A., Romanelli, Angela, Adams, Sharlene, Konopleva, Marina Y
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Selective Targeting BET Family Bdii Bromodomain with Abbv-744 and BCL-2 with Venetoclax (ABT-199) Is Synergistic in Primary Acute Myeloid Leukemia Models
Cai, Tianyu, Kuruvilla, Vinitha Mary, Lin, Xiaoyu, Uziel, Tamar, Lu, Xin, Zhang, Lu, Huang, Xiaoli, Zhang, Qi, Cavazos, Antonio, Han, Lina, Shen, Yu, Konopleva, Marina Y
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Abstract LB-261: Targeting BET Family Bromodomain with ABBV-075 and BCL-2 with venetoclax (ABT-199) is synergistic in primary acute myeloid leukemia models
Cai, Tianyu, Kuruvilla, Vinitha Mary, Uziel, Tamar, Zhang, Qi, Han, Lina, Cavazos, Antonio, Shen, Yu, Konopleva, Marina
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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The Direct Interactions with Bone Marrow Microenvironment Confer Resistance to the Inhibition of Oxidative Phosphorylation in AML
Tabe, Yoko, Saito, Kaori, Yamatani, Kotoko, Yang, Haeun, Jacamo, Rodrigo, Ma, Helen, Ruvolo, Vivian, Zhang, Qi, Kuruvilla, Vinitha Mary, Baran, Natalia, Imoto, Junichi, Ikeo, Kazuho, Suzuki, Koya, Miida, Takashi, Andreeff, Michael, Vellano, Christopher P, Marszalek, Joseph R, Konopleva, Marina
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
AML Cells Alter Bone Homeostasis By Promoting the Formation of Immature Bone and Resorption of Mature Bone That Supports Leukemia Progression
Tyagi, Anudishi, Yuan, Bin, Ly, Stanley, El-Dana, Fouad, Kuruvilla, Vinitha Mary, Zhang, Qi, Peterson, Christine B, Zhou, Xin, deCrombrugghe, Benoit, Andreeff, Michael, Konopleva, Marina, Amini, Behrang, Battula, Venkata Lokesh
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Targeting the Second Bromodomain (BDII) of BET Family with Abbv-744 Results in Robust Anti-Leukemia Activity in AML Models with Excellent In Vivo Tolerability
Cai, Tianyu, Kuruvilla, Vinitha Mary, Uziel, Tamar, Zhang, Qi, Han, Lina, Cavazos, Antonio, Shen, Yu, Konopleva, Marina Y., Lin, Xiaoyu, Lu, Xin, Zhang, Lu
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Targeting DHODH with AG-636 Induces Apoptosis and Differentiation and Inhibits Mitochondrial Function in AML, Translating into Anti-Tumor Efficacy in Vitro and in Vivo
Zeng, Zhihong, Baran, Natalia, Konoplev, Sergej, Cavazos, Antonio, Zhang, Qi, Kuruvilla, Vinitha Mary, Lorenzi, Philip, Kantarjian, Hagop M., Andreeff, Michael, DiNardo, Courtney D., Murtie, Joshua, Ulanet, Danielle, Konopleva, Marina Y
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Targeting BCL-XL By Protac DT2216 Effectively Eliminates Leukemia Cells in T-ALL Pre-Clinical Models
Zhang, Qi, Khan, Sajid, Zhang, Xuan, Kuruvilla, Vinitha Mary, Ghotbaldini, Sanaz, Wells, Julia, Baran, Natalia, Cai, Tianyu, Han, Lina, Ferrando, Adolfo, Kim, Yong-Mi, Zheng, Guangrong, Zhou, Daohong, Konopleva, Marina Y
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Inhibition of Mcl-1 Enhances the Efficacy of Tyrosine Kinase Inhibition in FLT3 Mutated AML and Synergizes with Venetoclax Targeting AML Stem Cells
Carter, Bing Z, Tao, Wenjing, Mak, Po Yee, Zhang, Qi, Wang, Xiangmeng, Kuruvilla, Vinitha Mary, Stewart, Carli, Ruvolo, Vivian, Battula, Venkata Lokesh, Konopleva, Marina Y, Caenepeel, Sean, Canon, Jude, Hughes, Paul, Morrow, PK, Andreeff, Michael
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Mitochondrial Oxphos As Survival Mechanism of Minimal Residual AML Cells after Induction Chemotherapy : Survival Benefit By Complex I Inhibition with Iacs-010759
Han, Lina, Cavazos, Antonio, Baran, Natalia, Zhang, Qi, Kuruvilla, Vinitha Mary, Gay, Jason P, Feng, Ningping, Battula, Venkata Lokesh, Kantarjian, Hagop M., Daver, Naval G., Marszalek, Joseph R, Andreeff, Michael, Konopleva, Marina Y
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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AZA + Glutaminase Inhibition with Telaglenastat (CB-839) for Advanced MDS: An Updated Interim Analysis
Saxena, Kapil, Konopleva, Marina, Bhagat, Tushar D, Guerra, Veronica A, Maduike, Rita, Tiziani, Stefano, Borthakur, Gautam, Jabbour, Elias, Pemmaraju, Naveen, Kadia, Tapan M., Short, Nicholas J., Burger, Jan A., Kornblau, Steven M., Daver, Naval, Naqvi, Kiran, Cai, Tianyu, Kuruvilla, Vinitha Mary, Kantarjian, Hagop M., Garcia-Manero, Guillermo, Verma, Amit, DiNardo, Courtney D.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Pre-Clinical Efficacy of CD123-Targeting Antibody-Drug Conjugate IMGN632 in Blastic Plasmacytoid Dentritic Cell Neoplasm (BPDCN) Models
Zhang, Qi, Cai, Tianyu, Han, Lina, Kuruvilla, Vinitha Mary, Adams, Sharlene, Callum, Sloss M, Harutyunyan, Karine, Lane, Andrew A., Kovtun, Yelena, Daver, Naval G., Pemmaraju, Naveen, McKay, Patrick Zweider, Konopleva, Marina Y.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Efficacy Proof of Concept for Allogeneic CD123 Targeting CAR T-Cells Against Primary Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): Efficient Control of Tumor Progression in PDX Model and Potential Loss of CD123 Expression in Relapsed Disease
Cai, Tianyu, Black, Kathryn L, Naqvi, Ammar S., Taylor, Deanne, Zhao, Ming, Yuan, Qi, Sugita, Mayumi, Galetto, Roman, Gouble, Agnès, Smith, Julianne N.P., Cavazos, Antonio, Han, Lina, Zhang, Qi, Kuruvilla, Vinitha Mary, Ma, Helen, Konoplev, Sergej, Tang, Guilin, Gu, Jun, Su, Xiaoping, Neelapu, Sattva S, Lane, Andrew A., Kantarjian, Hagop M., Guzman, Monica L., Pemmaraju, Naveen, Thomas-Tikhonenko, Andrei, Konopleva, Marina Y
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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