Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase
Feng, Danqing, Biftu, Tesfaye, Romero, F. Anthony, Kekec, Ahmet, Dropinski, James, Kassick, Andrew, Xu, Shiyao, Kurtz, Marc M, Gollapudi, Anantha, Shao, Qing, Yang, Xiaodong, Lu, Ku, Zhou, Gaochao, Kemp, Daniel, Myers, Robert W, Guan, Hong-Ping, Trujillo, Maria E, Li, Cai, Weber, Ann, Sebhat, Iyassu K
Published in ACS medicinal chemistry letters (11.01.2018)
Published in ACS medicinal chemistry letters (11.01.2018)
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Identification, localization and receptor characterization of novel mammalian substance P-like peptides
Kurtz, Marc M, Wang, Ruiping, Clements, Michelle K, Cascieri, Margaret A, Austin, Christopher P, Cunningham, Barry R, Chicchi, Gary G, Liu, Qingyun
Published in Gene (21.08.2002)
Published in Gene (21.08.2002)
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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Myers, Robert W., Guan, Hong-Ping, Ehrhart, Juliann, Petrov, Aleksandr, Prahalada, Srinivasa, Tozzo, Effie, Yang, Xiaodong, Kurtz, Marc M., Trujillo, Maria, Trotter, Dinko Gonzalez, Feng, Danqing, Xu, Shiyao, Eiermann, George, Holahan, Marie A., Rubins, Daniel, Conarello, Stacey, Niu, Xiaoda, Souza, Sandra C., Miller, Corin, Liu, Jinqi, Lu, Ku, Feng, Wen, Li, Ying, Painter, Ronald E., Milligan, James A., He, Huaibing, Liu, Franklin, Ogawa, Aimie, Wisniewski, Douglas, Rohm, Rory J., Wang, Liyang, Bunzel, Michelle, Qian, Ying, Zhu, Wei, Wang, Hongwu, Bennet, Bindu, Scheuch, Lisa LaFranco, Fernandez, Guillermo E., Li, Cai, Klimas, Michael, Zhou, Gaochao, van Heek, Margaret, Biftu, Tesfaye, Weber, Ann, Kelley, David E., Thornberry, Nancy, Erion, Mark D., Kemp, Daniel M., Sebhat, Iyassu K.
Published in Science (American Association for the Advancement of Science) (04.08.2017)
Published in Science (American Association for the Advancement of Science) (04.08.2017)
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Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
Muise, Eric S, Guan, Hong-Ping, Liu, Jinqi, Nawrocki, Andrea R, Yang, Xiaodong, Wang, Chuanlin, Rodríguez, Carlos G, Zhou, Dan, Gorski, Judith N, Kurtz, Marc M, Feng, Danqing, Leavitt, Kenneth J, Wei, Lan, Wilkening, Robert R, Apgar, James M, Xu, Shiyao, Lu, Ku, Feng, Wen, Li, Ying, He, Huaibing, Previs, Stephen F, Shen, Xiaolan, van Heek, Margaret, Souza, Sandra C, Rosenbach, Mark J, Biftu, Tesfaye, Erion, Mark D, Kelley, David E, Kemp, Daniel M, Myers, Robert W, Sebhat, Iyassu K
Published in PloS one (27.02.2019)
Published in PloS one (27.02.2019)
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The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine
LIN, Peter, LEHUA CHANG, KURTZ, Marc M, TSAO, Kwei-Lan C, WHEELDON, Alan, CARLSON, Emma J, ENG, Waisi, BURNS, H. Donald, HARGREAVES, Richard J, MILLS, Sander G, DEVITA, Robert J, YOUNG, Jonathan R, EID, Ronsar, XINCHUN TONG, SONG ZHENG, BALL, Richard G, TSOU, Nancy N, CHICCHI, Gary G
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
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Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists
THOMSON, Christopher G, CARLSON, Emma, CHICCHI, Gary G, KULAGOWSKI, Janusz J, KURTZ, Marc M, SWAIN, Christopher J, TSAO, Kwei-Lan C, WHEELDON, Alan
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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Journal Article
4,4-Disubstituted cyclohexylamine NK1 receptor antagonists II
COOPER, Laura C, CARLSON, Emma J, RYCROFT, Wayne, TSAO, Kwei-Lan, SWAIN, Christopher J, CASTRO, Jose L, CHICCHI, Gary G, DINNELL, Kevin, DI SALVO, Jerry, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Marc M, RIDGILL, Mark P
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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Journal Article
Potent, Brain-Penetrant, Hydroisoindoline-Based Human Neurokinin-1 Receptor Antagonists
Jiang, Jinlong, Bunda, Jaime L, Doss, Geoge A, Chicchi, Gary G, Kurtz, Marc M, Tsao, Kwei-Lan C, Tong, Xinchun, Zheng, Song, Upthagrove, Alana, Samuel, Koppara, Tschirret-Guth, Richard, Kumar, Sanjeev, Wheeldon, Alan, Carlson, Emma J, Hargreaves, Richard, Burns, Donald, Hamill, Terence, Ryan, Christine, Krause, Stephen M, Eng, WaiSi, DeVita, Robert J, Mills, Sander G
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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High-Throughput Simultaneous Analysis of RNA, Protein, and Lipid Biomarkers in Heterogeneous Tissue Samples
REISER, Vladimir, SMITH, Ryan C, TANEN, Michael R, LAZAR, Gloria, ZIEBA, Renata, ICHETOVKIN, Marina, ZHU CHEN, O'NEILL, Edward A, TANAKA, Wesley K, MARTON, Matthew J, JASON LIAO, MORRIS, Mark, JIYAN XUE, HAILMAN, Eric, TOKIWA, George Y, PLUMP, Andrew S, KURTZ, Marc M, RONG LIU, LEGRAND, Cheryl, XUANMIN HE, XIANG YU, PEGGY WONG, HINCHCLIFFE, John S
Published in Clinical chemistry (Baltimore, Md.) (01.11.2011)
Published in Clinical chemistry (Baltimore, Md.) (01.11.2011)
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Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists
Morriello, Gregori J, Devita, Robert J, Mills, Sander G, Young, Jonathan R, Lin, Peter, Doss, George, Chicchi, Gary G, Demartino, Julie, Kurtz, Marc M, Tsao, Kwei-Lan C, Carlson, Emma, Townson, Karen, Wheeldon, Alan, Boyce, Susan, Collinson, Neil, Rupniak, Nadia, Moore, Stephen
Published in Bioorganic & medicinal chemistry (01.03.2008)
Published in Bioorganic & medicinal chemistry (01.03.2008)
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Journal Article
Tetrahydroindolizinone NK1 antagonists
JIANMING BAO, HUAGANG LU, MILLS, Sander G, DEVITA, Robert J, MORRIELLO, Gregori J, CARLSON, Emma J, WHEELDON, Alan, CHICCHI, Gary G, KURTZ, Marc M, TSAO, Kwei-Lan C, SONG ZHENG, XINCHUN TONG
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
Published in Bioorganic & medicinal chemistry letters (01.04.2010)
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Journal Article
Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists
YOUNG, Jonathan R, EID, Ronsar, TURNER, Cherilyn, DEVITA, Robert J, KURTZ, Marc M, TSAO, Kwei-Lan C, CHICCHI, Gary G, WHEELDON, Alan, CARLSON, Emma, MILLS, Sander G
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
Published in Bioorganic & medicinal chemistry letters (01.10.2007)
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Journal Article
1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK 1) antagonists
Huscroft, Ian T., Carlson, Emma J., Chicchi, Gary G., Kurtz, Marc M., London, Clare, Raubo, Piotr, Wheeldon, Alan, Kulagowski, Janusz J.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
NK1 antagonists based on seven membered lactam scaffolds
ELLIOTT, Jason M, CARLSON, Emma J, WHEELDON, Alan, CHICCHI, Gary G, DIRAT, Olivier, DOMINGUEZ, Maria, GERHARD, Ute, JELLEY, Richard, JONES, A. Brian, KURTZ, Marc M, TSAO, Kwei Lan
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Journal Article
Comparison of the functional blockade of rat substance P (NK 1) receptors by GR205171, RP67580, SR140333 and NKP-608
Rupniak, Nadia M.J, Carlson, Emma J, Shepheard, Sara, Bentley, Graham, Williams, Angela R, Hill, Alastair, Swain, Christopher, Mills, Sander G, Di Salvo, Jerry, Kilburn, Ruth, Cascieri, Margaret A, Kurtz, Marc M, Tsao, Kwei-Lan, Gould, Sandra L, Chicchi, Gary G
Published in Neuropharmacology (01.08.2003)
Published in Neuropharmacology (01.08.2003)
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Journal Article
2-Aryl indole NK1 receptor antagonists : Optimisation of the 2-aryl ring and the indole nitrogen substituent
DINNELL, Kevin, CHICCHI, Gary G, SWAIN, Christopher J, DHAR, Madhumeeta J, ELLIOTT, Jason M, HOLLINGWORTH, Gregory J, KURTZ, Marc M, RIDGILL, Mark P, RYCROFT, Wayne, TSAO, Kwei-Lan, WILLIAMS, Angela R
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
Published in Bioorganic & medicinal chemistry letters (07.05.2001)
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Journal Article
Spirocyclic NK1 antagonists I:[4.5] and [5.5]-spiroketals
SEWARD, Eileen M, CARLSON, Emma, SADOWSKI, Sharon J, SWAIN, Christopher J, WILLIAMS, Brian J, HARRISON, Timothy, HAWORTH, Karen E, HERBERT, Richard, KELLEHER, Fintan J, KURTZ, Marc M, MOSELEY, Jonathan, OWEN, Simon N, OWENS, Andrew P
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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Journal Article
Novel lactam NK1 antagonists with anti-emetic activity
HOLLINGWORTH, Gregory J, CARLSON, Emma J, KURTZ, Marc M, RYCROFT, Wayne, TATTERSALL, F. David, TSAO, Kwei-Lan, SWAIN, Christopher J, CASTRO, José L, CHICCHI, Gary G, CLARK, Natalie, COOPER, Laura C, DIRAT, Olivier, DI SALVO, Jerry, ELLIOTT, Jason M, KILBURN, Ruth
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
4,4-Disubstituted cyclohexylamine NK1 receptor antagonists I
ELLIOTT, Jason M, CASTRO, Jose L, SWAIN, Christopher J, TSAO, Kwei-Lan, LIHU YANG, CHICCHI, Gary G, COOPER, Laura C, DINNELL, Kevin, HOLLINGWORTH, Gregory J, RIDGILL, Mark P, RYCROFT, Wayne, KURTZ, Marc M, SHAW, Duncan E
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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Journal Article
Selective Protection and Relative Importance of the Carboxylic Acid Groups of Zaragozic Acid A for Squalene Synthase Inhibition
Biftu, Tesfaye, Acton, John J, Berger, Gregory D, Bergstrom, James D, Dufresne, Claude, Kurtz, Marc M, Marquis, Robert W, Parsons, William H, Rew, Deborah R, Wilson, Kenneth E
Published in Journal of medicinal chemistry (01.02.1994)
Published in Journal of medicinal chemistry (01.02.1994)
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