The Ryanodine Receptor as a Sensor for Intracellular Environments in Muscles
Kobayashi, Takuya, Kurebayashi, Nagomi, Murayama, Takashi
Published in International journal of molecular sciences (06.10.2021)
Published in International journal of molecular sciences (06.10.2021)
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Journal Article
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke
Yamazawa, Toshiko, Kobayashi, Takuya, Kurebayashi, Nagomi, Konishi, Masato, Noguchi, Satoru, Inoue, Takayoshi, Inoue, Yukiko U., Nishino, Ichizo, Mori, Shuichi, Iinuma, Hiroto, Manaka, Noriaki, Kagechika, Hiroyuki, Uryash, Arkady, Adams, Jose, Lopez, Jose R., Liu, Xiaochen, Diggle, Christine, Allen, Paul D., Kakizawa, Sho, Ikeda, Keigo, Lin, Bangzhong, Ikemi, Yui, Nunomura, Kazuto, Nakagawa, Shinsaku, Sakurai, Takashi, Murayama, Takashi
Published in Nature communications (13.07.2021)
Published in Nature communications (13.07.2021)
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Journal Article
Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations
Kobayashi, Takuya, Tsutsumi, Akihisa, Kurebayashi, Nagomi, Saito, Kei, Kodama, Masami, Sakurai, Takashi, Kikkawa, Masahide, Murayama, Takashi, Ogawa, Haruo
Published in Nature communications (20.05.2022)
Published in Nature communications (20.05.2022)
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Co-Phenotype of Left Ventricular Non-Compaction Cardiomyopathy and Atypical Catecholaminergic Polymorphic Ventricular Tachycardia in Association With R169Q, a Ryanodine Receptor Type 2 Missense Mutation
Nozaki, Yoshihiro, Kato, Yoshiaki, Uike, Kiyoshi, Yamamura, Kenichiro, Kikuchi, Masahiro, Yasuda, Maki, Ohno, Seiko, Horie, Minoru, Murayama, Takashi, Kurebayashi, Nagomi, Horigome, Hitoshi
Published in Circulation Journal (24.01.2020)
Published in Circulation Journal (24.01.2020)
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Journal Article
Development of a water-soluble ryanodine receptor 1 inhibitor
Ishida, Ryosuke, Mori, Shuichi, Murayama, Takashi, Nakamichi, Ayaka, Chai, Xikun, Kurebayashi, Nagomi, Iinuma, Hiroto, Kagechika, Hiroyuki
Published in Bioorganic & medicinal chemistry (15.11.2022)
Published in Bioorganic & medicinal chemistry (15.11.2022)
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Journal Article
Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating
Oyama, Kotaro, Zeeb, Vadim, Yamazawa, Toshiko, Kurebayashi, Nagomi, Kobirumaki-Shimozawa, Fuyu, Murayama, Takashi, Oyamada, Hideto, Noguchi, Satoru, Inoue, Takayoshi, Inoue, Yukiko U., Nishino, Ichizo, Harada, Yoshie, Fukuda, Norio, Ishiwata, Shin’ichi, Suzuki, Madoka
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2022)
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Journal Article
Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels
Murayama, Takashi, Kurebayashi, Nagomi, Ishigami-Yuasa, Mari, Mori, Shuichi, Suzuki, Yukina, Akima, Ryunosuke, Ogawa, Haruo, Suzuki, Junji, Kanemaru, Kazunori, Oyamada, Hideto, Kiuchi, Yuji, Iino, Masamitsu, Kagechika, Hiroyuki, Sakurai, Takashi
Published in Molecular pharmacology (01.07.2018)
Published in Molecular pharmacology (01.07.2018)
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Journal Article
Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel
Murayama, Takashi, Kurebayashi, Nagomi, Ogawa, Haruo, Yamazawa, Toshiko, Oyamada, Hideto, Suzuki, Junji, Kanemaru, Kazunori, Oguchi, Katsuji, Iino, Masamitsu, Sakurai, Takashi
Published in Human mutation (01.11.2016)
Published in Human mutation (01.11.2016)
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Journal Article
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2
Kurebayashi, Nagomi, Murayama, Takashi, Ota, Ryosaku, Suzuki, Junji, Kanemaru, Kazunori, Kobayashi, Takuya, Ohno, Seiko, Horie, Minoru, Iino, Masamitsu, Yamashita, Fumiyoshi, Sakurai, Takashi
Published in The Journal of general physiology (05.09.2022)
Published in The Journal of general physiology (05.09.2022)
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Journal Article
A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment
Ishida, Ryosuke, Kurebayashi, Nagomi, Iinuma, Hiroto, Zeng, Xi, Mori, Shuichi, Kodama, Masami, Murayama, Takashi, Masuno, Hiroyuki, Takeda, Fumi, Kawahata, Masatoshi, Tanatani, Aya, Miura, Aya, Nishio, Hajime, Sakurai, Takashi, Kagechika, Hiroyuki
Published in European journal of medicinal chemistry (15.12.2023)
Published in European journal of medicinal chemistry (15.12.2023)
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Journal Article
Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease
Hori, Atsushi, Inaba, Haruka, Hato, Takashi, Tanaka, Kimie, Sato, Shoichi, Okamoto, Mizuho, Horiuchi, Yuna, Paran, Faith Jessica, Tabe, Yoko, Mori, Shusuke, Rosales, Corina, Akamatsu, Wado, Murayama, Takashi, Kurebayashi, Nagomi, Sakurai, Takashi, Ai, Tomohiko, Miida, Takashi
Published in PloS one (2024)
Published in PloS one (2024)
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Journal Article
An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice
Okabe, Yuta, Murakoshi, Nobuyuki, Kurebayashi, Nagomi, Inoue, Hana, Ito, Yoko, Murayama, Takashi, Miyoshi, Chika, Funato, Hiromasa, Ishii, Koichiro, Xu, Dongzhu, Tajiri, Kazuko, Qin, Rujie, Aonuma, Kazuhiro, Murakata, Yoshiko, Song, Zonghu, Wakana, Shigeharu, Yokoyama, Utako, Sakurai, Takashi, Aonuma, Kazutaka, Ieda, Masaki, Yanagisawa, Masashi
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2024)
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Journal Article
A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery
Murayama, Takashi, Kurebayashi, Nagomi, Numaga-Tomita, Takuro, Kobayashi, Takuya, Okazaki, Satoru, Yamashiro, Kyosuke, Nakada, Tsutomu, Mori, Shuichi, Ishida, Ryosuke, Kagechika, Hiroyuki, Yamada, Mitsuhiko, Sakurai, Takashi
Published in The Journal of general physiology (05.12.2022)
Published in The Journal of general physiology (05.12.2022)
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Journal Article
Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome
Hirose, Sayako, Murayama, Takashi, Tetsuo, Naoyuki, Hoshiai, Minako, Kise, Hiroaki, Yoshinaga, Masao, Aoki, Hisaaki, Fukuyama, Megumi, Wuriyanghai, Yimin, Wada, Yuko, Kato, Koichi, Makiyama, Takeru, Kimura, Takeshi, Sakurai, Takashi, Horie, Minoru, Kurebayashi, Nagomi, Ohno, Seiko
Published in Europace (London, England) (02.03.2022)
Published in Europace (London, England) (02.03.2022)
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A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain
Uzu, Miaki, Nonaka, Miki, Miyano, Kanako, Sato, Hiromi, Kurebayashi, Nagomi, Yanagihara, Kazuyoshi, Sakurai, Takashi, Hisaka, Akihiro, Uezono, Yasuhito
Published in Journal of pharmacological sciences (01.05.2019)
Published in Journal of pharmacological sciences (01.05.2019)
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