133 CRISPR/Cas9 gene-edited allogeneic CAR-T cells targeting CD33 show high preclinical efficacy against AML without long-term hematopoietic toxicity
Terrett, Jonathan, Mcewan, Brigid, Hostetter, Daniel, Gamboa, Luis, Kuppuraju, Meghna, Ghonime, Mohammed, Chain, Robert, Padalia, Zinkal, Kalaitzidis, Demetrios
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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274 Development of CTX112 a next generation allogeneic multiplexed CRISPR-edited CART cell therapy with disruptions of the TGFBR2 and Regnase-1 genes for improved manufacturing and potency
Kalaitzidis, Demetrios, Ghonime, Mohammed, Chain, Robert, Jaishankar, Nivedita, Settipane, Davis, Padalia, Zinkal, Zakas, Lauren, Kuppuraju, Meghna, Tetteh, Paul, Dequeant, Mary-Lee, Karnik, Sushant, Massilamany, Chandirasegaran, McEwan, Brigid, Dar, Henia, Allen, Melanie, Serwer, Laura, Nguyen, Thao, Butler-Gauthier, Melanie, Sripakdeevong, Parin, Nagar, Shashwat, Tang, Yin, Flanagan, Nicole, Huang, Elaine, Phuyal, Shashwant, Dunn, Andrew, Koch, Elizabeth, Sula, Erisa, Waldman, Jacob, Zhang, Maria Lei, Loaiza, Cristian, Thorstensen, Erin, Steiger, Keith, Schum, Katie, Urbaez, Kayla, Ma, Anna, Weaver, Annie Yang, Finch, Christopher, Cohen, Sarah, Morrow, PK, Benton, Mark, Terrett, Jonathan
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Abstract 880: Allogeneic CAR-T cell products containing 10 gene edits using CRISPR/Cas9 can retain full functionality in vivo and in vitro
McEwan, Brigid, Kuppuraju, Meghna, Padalia, Zinkal, Terrett, Jonathan, Kalaitzidis, Demetrios
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 879: Functional and single-cell assessment of CRISPR-modified CAR-T cells from NSCLC patients and healthy donors
Padalia, Zinkal, Dunn, Andrew, Karagiannis, Konstantinos, McEwan, Brigid, Kuppuraju, Meghna, Sagert, Jason, Karnik, Sushant, Dequeant, Mary-Lee, Terrett, Jonathan, Kalaitzidis, Demetrios
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract ND02: CTX112 and CTX131: Next-generation CRISPR/Cas9-engineered allogeneic (allo) CAR T cells incorporating novel edits that increase potency and efficacy in the treatment of lymphoid and solid tumors
Terrett, Jonathan A., Kalaitzidis, Demetrios, Dequeant, Mary-Lee, Karnik, Sushant, Ghonime, Mohammed, Guo, Changan, Chain, Robert, Heath, Heidi, Jaishankar, Nivedita, Yuen, Rachel, Settipane, Davis, Padalia, Zinkal, Zakas, Lauren, Kuppuraju, Meghna, Tetteh, Paul, Massilamany, Chandirasegaran, McEwan, Brigid, Leary, Glenn, Dar, Henia, Ferulo, Daniel, Allen, Melanie, Tipton, Kimberley, Serwer, Laura, Nguyen, Thao, Butler-Gauthier, Melanie, Sripakdeevong, Parin, Nagar, Shashwat D., Tang, Yin, Chaudhari, Hemangi, Flanagan, Nicole, Huang, Elaine, Phuyal, Shashwant, Koch, Elizabeth, Dunn, Andrew, Sula, Erisa, Waldman, Jacob, Loaiza, Cristian, Zhang, Maria Lei, Thorstensen, Erin, Steiger, Keith, Schum, Katie, Urbaez, Kayla, Benton, Mark, Ma, Anna, Cohen, Sarah, Weaver, Annie, Finch, Christopher, Morrow, Phuong Khanh
Published in Cancer research (Chicago, Ill.) (29.05.2023)
Published in Cancer research (Chicago, Ill.) (29.05.2023)
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