Design and Synthesis of 3-(β-d-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential
Kun, Sándor, Mathomes, Rachel T, Docsa, Tibor, Somsák, László, Hayes, Joseph M
Published in Molecules (Basel, Switzerland) (28.03.2023)
Published in Molecules (Basel, Switzerland) (28.03.2023)
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Journal Article
Glycosylation with ulosonates under Mitsunobu conditions: scope and limitations
Kánya, Nándor, Kun, Sándor, Batta, Gyula, Somsák, László
Published in New journal of chemistry (14.09.2020)
Published in New journal of chemistry (14.09.2020)
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Journal Article
Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase
Kun, Sándor, Bokor, Éva, Sipos, Ádám, Docsa, Tibor, Somsák, László
Published in Molecules (Basel, Switzerland) (15.03.2018)
Published in Molecules (Basel, Switzerland) (15.03.2018)
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Journal Article
Glucopyranosylidene-spiro-benzo[b][1,4]oxazinones and -benzo[b][1,4]thiazinones: Synthesis and Investigation of Their Effects on Glycogen Phosphorylase and Plant Growth Inhibition
Kun, Sándor, Kánya, Nándor, Galó, Norbert, Páhi, András, Mándi, Attila, Kurtán, Tibor, Makleit, Péter, Veres, Szilvia, Sipos, Ádám, Docsa, Tibor, Somsák, László
Published in Journal of agricultural and food chemistry (19.06.2019)
Published in Journal of agricultural and food chemistry (19.06.2019)
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Journal Article
Identification of C‑β‑d‑Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies
Barr, Daniel, Szennyes, Eszter, Bokor, Éva, Al-Oanzi, Ziad H, Moffatt, Colin, Kun, Sándor, Docsa, Tibor, Sipos, Ádám, Davies, Matthew P, Mathomes, Rachel T, Snape, Timothy J, Agius, Loranne, Somsák, László, Hayes, Joseph M
Published in ACS chemical biology (19.07.2019)
Published in ACS chemical biology (19.07.2019)
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Journal Article
Glycogen phosphorylase inhibition improves beta cell function
Nagy, Lilla, Márton, Judit, Vida, András, Kis, Gréta, Bokor, Éva, Kun, Sándor, Gönczi, Mónika, Docsa, Tibor, Tóth, Attila, Antal, Miklós, Gergely, Pál, Csóka, Balázs, Pacher, Pal, Somsák, László, Bai, Péter
Published in British journal of pharmacology (01.01.2018)
Published in British journal of pharmacology (01.01.2018)
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Journal Article
New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase
Kun, Sándor, Bokor, Éva, Varga, Gergely, Szőcs, Béla, Páhi, András, Czifrák, Katalin, Tóth, Marietta, Juhász, László, Docsa, Tibor, Gergely, Pál, Somsák, László
Published in European journal of medicinal chemistry (09.04.2014)
Published in European journal of medicinal chemistry (09.04.2014)
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Journal Article
Dual-Target Compounds against Type 2 Diabetes Mellitus : Proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors
Sipos, Ádám, Szennyes, Eszter, Hajnal, Nikolett Éva, Kun, Sándor, Szabó, Katalin E, Uray, Karen, Somsák, László, Docsa, Tibor, Bokor, Éva
Published in Pharmaceuticals (Basel, Switzerland) (15.04.2021)
Published in Pharmaceuticals (Basel, Switzerland) (15.04.2021)
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Journal Article
Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase
Kantsadi, Anastassia L., Bokor, Éva, Kun, Sándor, Stravodimos, George A., Chatzileontiadou, Demetra S.M., Leonidas, Demetres D., Juhász-Tóth, Éva, Szakács, Andrea, Batta, Gyula, Docsa, Tibor, Gergely, Pál, Somsák, László
Published in European journal of medicinal chemistry (10.11.2016)
Published in European journal of medicinal chemistry (10.11.2016)
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Journal Article
New syntheses towards C-glycosyl type glycomimetics
Somsák, László, Bokor, Éva, Juhász, László, Kun, Sándor, Lázár, László, Juhász-Tóth, Éva, Tóth, Marietta
Published in Pure and applied chemistry (01.07.2019)
Published in Pure and applied chemistry (01.07.2019)
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Journal Article
In vivo functional analysis of L-rhamnose metabolic pathway in Aspergillus niger: a tool to identify the potential inducer of RhaR
Khosravi, Claire, Kun, Roland Sándor, Visser, Jaap, Aguilar-Pontes, María Victoria, de Vries, Ronald P, Battaglia, Evy
Published in BMC microbiology (06.11.2017)
Published in BMC microbiology (06.11.2017)
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Journal Article
The architecture of hydrogen and sulfur σ-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design
Kyriakis, Efthimios, Karra, Aikaterini G., Papaioannou, Olga, Solovou, Theodora, Skamnaki, Vassiliki T., Liggri, Panagiota G.V., Zographos, Spyros E., Szennyes, Eszter, Bokor, Éva, Kun, Sándor, Psarra, Anna-Maria G., Somsák, László, Leonidas, Demetres D.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
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Journal Article
A multidisciplinary study of 3-(β-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors
Kun, Sándor, Begum, Jaida, Kyriakis, Efthimios, Stamati, Evgenia C.V., Barkas, Thomas A., Szennyes, Eszter, Bokor, Éva, Szabó, Katalin E., Stravodimos, George A., Sipos, Ádám, Docsa, Tibor, Gergely, Pál, Moffatt, Colin, Patraskaki, Myrto S., Kokolaki, Maria C., Gkerdi, Alkistis, Skamnaki, Vassiliki T., Leonidas, Demetres D., Somsák, László, Hayes, Joseph M.
Published in European journal of medicinal chemistry (10.03.2018)
Published in European journal of medicinal chemistry (10.03.2018)
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Journal Article
van der Waals interactions govern C-β-d-glucopyranosyl triazoles’ nM inhibitory potency in human liver glycogen phosphorylase
Kantsadi, Anastassia L., Stravodimos, George A., Kyriakis, Efthimios, Chatzileontiadou, Demetra S.M., Solovou, Theodora G.A., Kun, Sándor, Bokor, Éva, Somsák, László, Leonidas, Demetres D.
Published in Journal of structural biology (01.07.2017)
Published in Journal of structural biology (01.07.2017)
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