Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors
Kung, Pei-Pei, Rui, Eugene, Bergqvist, Simon, Bingham, Patrick, Braganza, John, Collins, Michael, Cui, Mei, Diehl, Wade, Dinh, Dac, Fan, Connie, Fantin, Valeria R, Gukasyan, Hovhannes J, Hu, Wenyue, Huang, Buwen, Kephart, Susan, Krivacic, Cody, Kumpf, Robert A, Li, Gary, Maegley, Karen A, McAlpine, Indrawan, Nguyen, Lisa, Ninkovic, Sacha, Ornelas, Martha, Ryskin, Michael, Scales, Stephanie, Sutton, Scott, Tatlock, John, Verhelle, Dominique, Wang, Fen, Wells, Peter, Wythes, Martin, Yamazaki, Shinji, Yip, Brian, Yu, Xiu, Zehnder, Luke, Zhang, Wei-Guo, Rollins, Robert A, Edwards, Martin
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Kung, Pei-Pei, Bingham, Patrick, Brooun, Alexei, Collins, Michael, Deng, Ya-Li, Dinh, Dac, Fan, Connie, Gajiwala, Ketan S., Grantner, Rita, Gukasyan, Hovhannes J., Hu, Wenyue, Huang, Buwen, Kania, Robert, Kephart, Susan E., Krivacic, Cody, Kumpf, Robert A., Khamphavong, Penney, Kraus, Manfred, Liu, Wei, Maegley, Karen A., Nguyen, Lisa, Ren, Shijian, Richter, Dan, Rollins, Robert A., Sach, Neal, Sharma, Shikhar, Sherrill, John, Spangler, Jillian, Stewart, Albert E., Sutton, Scott, Uryu, Sean, Verhelle, Dominique, Wang, Hui, Wang, Shuiwang, Wythes, Martin, Xin, Shuibo, Yamazaki, Shinji, Zhu, Huichun, Zhu, JinJiang, Zehnder, Luke, Edwards, Martin
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance
Jensen-Pergakes, Kristen, Tatlock, John, Maegley, Karen A, McAlpine, Indrawan J, McTigue, Michele, Xie, Tao, Dillon, Christopher P, Wang, Yuli, Yamazaki, Shinji, Spiegel, Noah, Shi, Manli, Nemeth, Amy, Miller, Natalie, Hendrickson, Eleanore, Lam, Hieu, Sherrill, John, Chung, Chi-Yeh, McMillan, Elizabeth A, Bryant, Shannon Karlicek, Palde, Prakash, Braganza, John, Brooun, Alexei, Deng, Ya-Li, Goshtasbi, Vesta, Kephart, Susan E, Kumpf, Robert A, Liu, Wei, Patman, Ryan L, Rui, Eugene, Scales, Stephanie, Tran-Dube, Michelle, Wang, Fen, Wythes, Martin, Paul, Thomas A
Published in Molecular cancer therapeutics (01.01.2022)
Published in Molecular cancer therapeutics (01.01.2022)
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Development and Comprehensive Benchmark of a High-Quality AMBER-Consistent Small Molecule Force Field with Broad Chemical Space Coverage for Molecular Modeling and Free Energy Calculation
Xue, Bai, Yang, Qingyi, Zhang, Qiaochu, Wan, Xiao, Fang, Dong, Lin, Xiaolu, Sun, Guangxu, Gobbo, Gianpaolo, Cao, Fenglei, Mathiowetz, Alan M., Burke, Benjamin J., Kumpf, Robert A., Rai, Brajesh K., Wood, Geoffrey P. F., Pickard, Frank C., Wang, Junmei, Zhang, Peiyu, Ma, Jian, Jiang, Yide Alan, Wen, Shuhao, Hou, Xinjun, Zou, Junjie, Yang, Mingjun
Published in Journal of chemical theory and computation (23.01.2024)
Published in Journal of chemical theory and computation (23.01.2024)
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Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3–9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase
Taylor, Alexandria P, Swewczyk, Magdalena, Kennedy, Steven, Trush, Viacheslav V, Wu, Hong, Zeng, Hong, Dong, Aiping, Ferreira de Freitas, Renato, Tatlock, John, Kumpf, Robert A, Wythes, Martin, Casimiro-Garcia, Agustin, Denny, Rajiah Aldrin, Parikh, Mihir D, Li, Fengling, Barsyte-Lovejoy, Dalia, Schapira, Matthieu, Vedadi, Masoud, Brown, Peter J, Arrowsmith, Cheryl H, Owen, Dafydd R
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors
Kung, Pei-Pei, Rui, Eugene, Bergqvist, Simon, Bingham, Patrick, Braganza, John, Collins, Michael, Cui, Mei, Diehl, Wade, Dinh, Dac, Fan, Connie, Fantin, Valeria R, Gukasyan, Hovhannes J, Hu, Wenyue, Huang, Buwen, Kephart, Susan, Krivacic, Cody, Kumpf, Robert A, Li, Gary, Maegley, Karen A, McAlpine, Indrawan, Nguyen, Lisa, Ninkovic, Sacha, Ornelas, Martha, Ryskin, Michael, Scales, Stephanie, Sutton, Scott, Tatlock, John, Verhelle, Dominique, Wang, Fen, Wells, Peter, Wythes, Martin, Yamazaki, Shinji, Yip, Brian, Yu, Xiu, Zehnder, Luke, Zhang, Wei-Guo, Rollins, Robert A, Edwards, Martin
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure
Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
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Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase
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Published in Journal of medicinal chemistry (21.10.2004)
Published in Journal of medicinal chemistry (21.10.2004)
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Molecular recognition in aqueous media. New binding studies provide further insights into the cation-.pi. interaction and related phenomena
Kearney, Patrick C, Mizoue, Laura S, Kumpf, Robert A, Forman, Jonathan E, McCurdy, Alison, Dougherty, Dennis A
Published in Journal of the American Chemical Society (01.11.1993)
Published in Journal of the American Chemical Society (01.11.1993)
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Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361
CALABRESE, Christopher R, ALMASSY, Robert, LI, Jianke, MAEGLEY, Karen, NEWELL, David R, NOTARIANNI, Elena, STRATFORD, Ian J, SKALITZKY, Donald, THOMAS, Huw D, WANG, Ian-Zhen, WEBBER, Stephen E, WILLIAMS, Kaye J, BARTON, Stephanie, CURTIN, Nicola J, BATEY, Michael A, CALVERT, A. Hilary, CANAN-KOCH, Stacie, DURKACZ, Barbara W, HOSTOMSKY, Zdenek, KUMPF, Robert A, KYLE, Suzanne
Published in JNCI : Journal of the National Cancer Institute (07.01.2004)
Published in JNCI : Journal of the National Cancer Institute (07.01.2004)
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Parametrization of molecular mechanics calculations for the accurate description of hydrogen-bonding interactions
Damewood, James R, Kumpf, Robert A, Muhlbauer, Wolfgang C. F, Urban, Joseph J, Eksterowicz, John E
Published in Journal of physical chemistry (1952) (01.08.1990)
Published in Journal of physical chemistry (1952) (01.08.1990)
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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)‑5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)‑one (PF-06821497)
Kung, Pei-Pei, Bingham, Patrick, Brooun, Alexei, Collins, Michael, Deng, Ya-Li, Dinh, Dac, Fan, Connie, Gajiwala, Ketan S, Grantner, Rita, Gukasyan, Hovhannes J, Hu, Wenyue, Huang, Buwen, Kania, Robert, Kephart, Susan E, Krivacic, Cody, Kumpf, Robert A, Khamphavong, Penney, Kraus, Manfred, Liu, Wei, Maegley, Karen A, Nguyen, Lisa, Ren, Shijian, Richter, Dan, Rollins, Robert A, Sach, Neal, Sharma, Shikhar, Sherrill, John, Spangler, Jillian, Stewart, Albert E, Sutton, Scott, Uryu, Sean, Verhelle, Dominique, Wang, Hui, Wang, Shuiwang, Wythes, Martin, Xin, Shuibo, Yamazaki, Shinji, Zhu, Huichun, Zhu, JinJiang, Zehnder, Luke, Edwards, Martin
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Design, Synthesis, and Evaluation of 3,4-Dihydro-2 H -[1,4]diazepino[6,7,1- hi ]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase
Tikhe, Jayashree G., Webber, Stephen E., Hostomsky, Zdenek, Maegley, Karen A., Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J., Kumpf, Robert A., Boritzki, Theodore J., Zhang, Cathy, Calabrese, Chris R., Curtin, Nicola J., Kyle, Suzanne, Thomas, Huw D., Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T., Griffin, Roger J., Newell, David R.
Published in Journal of medicinal chemistry (01.10.2004)
Published in Journal of medicinal chemistry (01.10.2004)
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HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
HUANG BUWEN, LEWIS KATHLEEN K, DRESS KLAUS R, KUMPF ROBERT A, CANAN-KOCH STACIE S, MATTHEWS JEAN J, SAKATA SYLVIE K, ALEGRIA LARRY A, VIRGIL SCOTT C
Year of Publication 09.06.2005
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Year of Publication 09.06.2005
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ARYL AND HETEROARYL FUSED LACTAMS
MCALPINE, INDRAWAN JAMES IJ, NINKOVIC, SACHA S, EDWARDS, MARTIN PAUL MP, KUMPF, ROBERT ARNOLD RA, RUI, EUGENE YUANJIN EY, WYTHES, MARTIN JAMES MJ, ZEHNDER, LUKE RAYMOND LR, SUTTON, SCOTT CHANNING SC, KUNG, PEI-PEI P-P, TATLOCK, JOHN HOWARD JH
Year of Publication 18.03.2016
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Year of Publication 18.03.2016
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