CCX559 is a potent, orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity
Sullivan, Kathleen M C, Vilalta, Marta, Ertl, Linda S, Wang, Yu, Dunlap, Carolyn, Ebsworth, Karen, Zhao, Bin N, Li, Shijie, Zeng, Yibin, Miao, Zhenhua, Fan, Pingchen, Mali, Venkat, Lange, Christopher, McMurtrie, Darren, Yang, Ju, Lui, Rebecca, Scamp, Ryan, Chhina, Vicky, Kumamoto, Alice, Yau, Simon, Dang, Ton, Easterday, Ashton, Liu, Shirley, Miao, Shichang, Charo, Israel, Schall, Thomas J, Zhang, Penglie
Published in PloS one (07.06.2023)
Published in PloS one (07.06.2023)
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214 The KRASG12D(ON) covalent tricomplex inhibitor RM-044 increases tumor antigen presentation and TCR repertoire diversity to promote anti-tumor immunity in a preclinical model of KRASG12D mutant cancer
Shifrin, Nataliya Tovbis, Menard, Marie, Courtney, Haley, Ganesh, Swetha, Kumamoto, Alice, Seu, Lillian, Smith, Jacqueline AM, Quintana, Elsa
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Efficacy of Chemokine Receptor Inhibition in Treating IL-36α-Induced Psoriasiform Inflammation
Campbell, James J, Ebsworth, Karen, Ertl, Linda S, McMahon, Jeffrey P, Wang, Yu, Yau, Simon, Mali, Venkat R, Chhina, Vicky, Kumamoto, Alice, Liu, Shirley, Dang, Ton, Newland, Dale, Charo, Israel F, Zhang, Penglie, Schall, Thomas J, Singh, Rajinder
Published in The Journal of immunology (1950) (15.03.2019)
Published in The Journal of immunology (1950) (15.03.2019)
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Therapeutic Benefit of CCR2 Antagonism in a Model of Diabetic Nephropathy Suggests a Mechanism of Action Distinct from Nrf2 Activation: PO0943
Miao, Zhenhua, Zhao, Bin N., Ertl, Linda, Chhina, Vicky, Kumamoto, Alice L., Dang, Ton H., Yau, Simon K., Luong, Kenken, Zhang, Penglie, Sullivan, Kathleen M., Charo, Israel, Schall, Thomas J.
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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Abstract 1274: CCX559 is a potent orally-administered small molecule PD-L1 inhibitor that induces anti-tumor immunity
Li, Chris, Vilalta, Marta, Ertl, Linda S., Wang, Yu, Zeng, Yibin, Fan, Pingchen, Lange, Christopher, McMurtrie, Darren, Yang, Ju, Lui, Rebecca, Scamp, Ryan, Chhina, Vicky, Kumamoto, Alice, Ong, Ryan, Dang, Ton, Easterday, Ashton, Zhao, Niky, Liu, Shirley, Singh, Rajinder, Charo, Israel, Sullivan, Kathleen, Schall, Thomas J., Zhang, Penglie
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Targeting Chemokine Receptors CCR6 and CXCR2 in A Murine Model Of IL-36a-Induced Pustular Psoriasis
Campbell, James J, Ebsworth, Karen, Ertl, Linda, McMahon, Jeffrey P, Wang, Yu, Yau, Simon, Mali, Venkat R, Chhina, Vicky, Kumamoto, Alice, Liu, Shirley, Dang, Ton, Newland, Dale, Charo, Israel F, Zhang, Penglie, Schall, Thomas J, Singh, Rajinder
Published in The Journal of immunology (1950) (01.05.2019)
Published in The Journal of immunology (1950) (01.05.2019)
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Abstract 5693: Anti-tumor effect of orally available small molecule PD-L1 inhibitors in a murine model of colon adenocarcinoma
Li, Shijie "Chris", Vilalta, Marta, Ertl, Linda S., Wang, Yu, Zeng, Yibin, Fan, Pingchen, Lange, Christopher, McMurtrie, Darren, Yang, Ju, Lui, Rebecca, Ong, Ryan, Chhina, Vicky, Kumamoto, Alice, Yau, Simon, Dang, Ton, Easterday, Ashton, Liu, Shirley, Singh, Rajinder, Charo, Israel, Schall, Thomas J., Zhang, Penglie
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 581: Identification of potential biomarkers of response to RASMULTI(ON) plus anti-PD-1 combination in preclinical PDAC models
Seu, Lillian, Menard, Marie, Lee, Jasmine, Chow, Christopher, Blaj, Cristina, Ayala, Mariela Moreno, Shifrin, Nataliya, Salmon, Avery, Ganesh, Swetha, Wig, Philip, Kumamoto, Alice, Soto-Perez, Paola, Taavili, Tippy, Morton, Vivian, Evans, James W., Smith, Jacqueline A., Quintana, Elsa
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 1745: Inhibition of chemokine receptor 2 (CCR2) with a small molecule antagonist enhances the effectiveness of checkpoint inhibition by altering the tumor microenvironment in mouse colorectal tumors: Reducing tumor size and increasing long term survival
Campbell, James J., Janson, Christine, Ertl, Linda, Li, Chris, Miao, Zhenhua, Krasinski, Antoni, Lui, Rebecca, Mali, Venkat, McMahon, Jeffrey, Zheng, Yibin, Wang, Yu, Zang, Xiaoping, Chhina, Vicky, Vilalta, Marta, Kumamoto, Alice, Dang, Ton, Liu, Shirley, Yao, Simon, Zhang, Penglie, Schall, Thomas J., Singh, Rajinder
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Abstract 3475: RMC-9805, a first-in-class, mutant-selective, covalent and orally bioavailable KRASG12D(ON) inhibitor, promotes cancer-associated neoantigen recognition and synergizes with immunotherapy in preclinical models
Menard, Marie J., Chow, Christopher, Chen, Kevin, Blaj, Cristina, Shifrin, Nataliya Tovbis, Courtney, Haley, Nasholm, Nicole M., Pham, Anna, Kumamoto, Alice, Ganesh, Swetha, Evans, James W., Lawrence, Lindsey, Vonmelchert, Brian, Kwok-Parkhill, Amy C., Jiang, Jingjing, Knox, John E., Smith, Jacqueline, Quintana, Elsa
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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