Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
Wurst, Wolfgang, Müller, Marianne B, Zimmermann, Stephan, Sillaber, Inge, Hagemeyer, Thomas P, Deussing, Jan M, Timpl, Peter, Kormann, Michael S D, Droste, Susanne K, Kühn, Ralf, Reul, Johannes M H M, Holsboer, Florian
Published in Nature neuroscience (01.10.2003)
Published in Nature neuroscience (01.10.2003)
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Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
Chu, Van Trung, Weber, Timm, Wefers, Benedikt, Wurst, Wolfgang, Sander, Sandrine, Rajewsky, Klaus, Kühn, Ralf
Published in Nature biotechnology (01.05.2015)
Published in Nature biotechnology (01.05.2015)
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DNA Hypomethylation Perturbs the Function and Survival of CNS Neurons in Postnatal Animals
Fan, Guoping, Beard, Caroline, Chen, Richard Z, Csankovszki, Gyorgyi, Sun, Yi, Siniaia, Marina, Biniszkiewicz, Detlev, Bates, Brian, Lee, Peggy P, Kuhn, Ralf, Trumpp, Andreas, Poon, Chi-Sang, Wilson, Christopher B, Jaenisch, Rudolf
Published in The Journal of neuroscience (01.02.2001)
Published in The Journal of neuroscience (01.02.2001)
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Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function
Piwecka, Monika, Glažar, Petar, Hernandez-Miranda, Luis R., Memczak, Sebastian, Wolf, Susanne A., Rybak-Wolf, Agnieszka, Filipchyk, Andrei, Klironomos, Filippos, Jara, Cledi Alicia Cerda, Fenske, Pascal, Trimbuch, Thorsten, Zywitza, Vera, Plass, Mireya, Schreyer, Luisa, Ayoub, Salah, Kocks, Christine, Kühn, Ralf, Rosenmund, Christian, Birchmeier, Carmen, Rajewsky, Nikolaus
Published in Science (American Association for the Advancement of Science) (22.09.2017)
Published in Science (American Association for the Advancement of Science) (22.09.2017)
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AMEGIC++ 1.0, A Matrix Element Generator In C++
Krauss, Frank, Kuhn, Ralf, Soff, Gerhard
Published in The journal of high energy physics (27.02.2002)
Published in The journal of high energy physics (27.02.2002)
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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
Fecher, Caroline, Trovò, Laura, Müller, Stephan A, Snaidero, Nicolas, Wettmarshausen, Jennifer, Heink, Sylvia, Ortiz, Oskar, Wagner, Ingrid, Kühn, Ralf, Hartmann, Jana, Karl, Rosa Maria, Konnerth, Arthur, Korn, Thomas, Wurst, Wolfgang, Merkler, Doron, Lichtenthaler, Stefan F, Perocchi, Fabiana, Misgeld, Thomas
Published in Nature neuroscience (01.10.2019)
Published in Nature neuroscience (01.10.2019)
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Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes
Chu, Van Trung, Weber, Timm, Graf, Robin, Sommermann, Thomas, Petsch, Kerstin, Sack, Ulrike, Volchkov, Pavel, Rajewsky, Klaus, Kühn, Ralf
Published in BMC biotechnology (16.01.2016)
Published in BMC biotechnology (16.01.2016)
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Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line
Chu, Van Trung, Graf, Robin, Wirtz, Tristan, Weber, Timm, Favret, Jeremy, Li, Xun, Petsch, Kerstin, Tran, Ngoc Tung, Sieweke, Michael H., Berek, Claudia, Kühn, Ralf, Rajewsky, Klaus
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2016)
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Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs
Meyer, Katrina, Kirchner, Marieluise, Uyar, Bora, Cheng, Jing-Yuan, Russo, Giulia, Hernandez-Miranda, Luis R., Szymborska, Anna, Zauber, Henrik, Rudolph, Ina-Maria, Willnow, Thomas E., Akalin, Altuna, Haucke, Volker, Gerhardt, Holger, Birchmeier, Carmen, Kühn, Ralf, Krauss, Michael, Diecke, Sebastian, Pascual, Juan M., Selbach, Matthias
Published in Cell (20.09.2018)
Published in Cell (20.09.2018)
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Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth
Dzamukova, Maria, Brunner, Tobias M, Miotla-Zarebska, Jadwiga, Heinrich, Frederik, Brylka, Laura, Mashreghi, Mir-Farzin, Kusumbe, Anjali, Kühn, Ralf, Schinke, Thorsten, Vincent, Tonia L, Löhning, Max
Published in Nature communications (01.06.2022)
Published in Nature communications (01.06.2022)
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Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome
Inak, Gizem, Rybak-Wolf, Agnieszka, Lisowski, Pawel, Pentimalli, Tancredi M, Jüttner, René, Glažar, Petar, Uppal, Karan, Bottani, Emanuela, Brunetti, Dario, Secker, Christopher, Zink, Annika, Meierhofer, David, Henke, Marie-Thérèse, Dey, Monishita, Ciptasari, Ummi, Mlody, Barbara, Hahn, Tobias, Berruezo-Llacuna, Maria, Karaiskos, Nikos, Di Virgilio, Michela, Mayr, Johannes A, Wortmann, Saskia B, Priller, Josef, Gotthardt, Michael, Jones, Dean P, Mayatepek, Ertan, Stenzel, Werner, Diecke, Sebastian, Kühn, Ralf, Wanker, Erich E, Rajewsky, Nikolaus, Schuelke, Markus, Prigione, Alessandro
Published in Nature communications (26.03.2021)
Published in Nature communications (26.03.2021)
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The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4
Funk, Natalja, Munz, Marita, Ott, Thomas, Brockmann, Kathrin, Wenninger-Weinzierl, Andrea, Kühn, Ralf, Vogt-Weisenhorn, Daniela, Giesert, Florian, Wurst, Wolfgang, Gasser, Thomas, Biskup, Saskia
Published in Scientific reports (14.03.2019)
Published in Scientific reports (14.03.2019)
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A homology independent sequence replacement strategy in human cells using a CRISPR nuclease
Danner, Eric, Lebedin, Mikhail, de la Rosa, Kathrin, Kühn, Ralf
Published in Open biology (01.01.2021)
Published in Open biology (01.01.2021)
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CRISPR-Cas9-Mediated ELANE Mutation Correction in Hematopoietic Stem and Progenitor Cells to Treat Severe Congenital Neutropenia
Tran, Ngoc Tung, Graf, Robin, Wulf-Goldenberg, Annika, Stecklum, Maria, Strauß, Gabriele, Kühn, Ralf, Kocks, Christine, Rajewsky, Klaus, Chu, Van Trung
Published in Molecular therapy (02.12.2020)
Published in Molecular therapy (02.12.2020)
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Oscillations of MyoD and Hes1 proteins regulate the maintenance of activated muscle stem cells
Lahmann, Ines, Bröhl, Dominique, Zyrianova, Tatiana, Isomura, Akihiro, Czajkowski, Maciej T, Kapoor, Varun, Griger, Joscha, Ruffault, Pierre-Louis, Mademtzoglou, Despoina, Zammit, Peter S, Wunderlich, Thomas, Spuler, Simone, Kühn, Ralf, Preibisch, Stephan, Wolf, Jana, Kageyama, Ryoichiro, Birchmeier, Carmen
Published in Genes & development (01.05.2019)
Published in Genes & development (01.05.2019)
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Novel human neurodevelopmental and neurodegenerative disease associated with IRF2BPL gene variants-mechanisms and therapeutic avenues
Bauersachs, Daniel, Bomholtz, Louise, Del Rey Mateos, Sara, Kühn, Ralf, Lisowski, Pawel
Published in Frontiers in neuroscience (06.06.2024)
Published in Frontiers in neuroscience (06.06.2024)
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Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
Lowenstein, Elijah D., Ruffault, Pierre-Louis, Misios, Aristotelis, Osman, Kate L., Li, Huimin, Greenberg, Rachel S., Thompson, Rebecca, Song, Kun, Dietrich, Stephan, Li, Xun, Vladimirov, Nikita, Woehler, Andrew, Brunet, Jean-François, Zampieri, Niccolò, Kühn, Ralf, Liberles, Stephen D., Jia, Shiqi, Lewin, Gary R., Rajewsky, Nikolaus, Lever, Teresa E., Birchmeier, Carmen
Published in Neuron (Cambridge, Mass.) (19.07.2023)
Published in Neuron (Cambridge, Mass.) (19.07.2023)
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Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA
Wefers, Benedikt, Panda, Sudeepta K, Ortiz, Oskar, Brandl, Christina, Hensler, Svenja, Hansen, Jens, Wurst, Wolfgang, Kühn, Ralf
Published in Nature protocols (01.12.2013)
Published in Nature protocols (01.12.2013)
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Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
Wefers, Benedikt, Meyer, Melanie, Ortiz, Oskar, de Angelis, Martin Hrabé, Hansen, Jens, Wurst, Wolfgang, Kühn, Ralf
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2013)
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