The role of glial cells in multiple sclerosis disease progression
Healy, Luke M., Stratton, Jo Anne, Kuhlmann, Tanja, Antel, Jack
Published in Nature reviews. Neurology (01.04.2022)
Published in Nature reviews. Neurology (01.04.2022)
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An updated histological classification system for multiple sclerosis lesions
Kuhlmann, Tanja, Ludwin, Samuel, Prat, Alexandre, Antel, Jack, Brück, Wolfgang, Lassmann, Hans
Published in Acta neuropathologica (01.01.2017)
Published in Acta neuropathologica (01.01.2017)
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Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
Schafflick, David, Xu, Chenling A., Hartlehnert, Maike, Cole, Michael, Schulte-Mecklenbeck, Andreas, Lautwein, Tobias, Wolbert, Jolien, Heming, Michael, Meuth, Sven G., Kuhlmann, Tanja, Gross, Catharina C., Wiendl, Heinz, Yosef, Nir, Meyer zu Horste, Gerd
Published in Nature communications (14.01.2020)
Published in Nature communications (14.01.2020)
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Lesion stage-dependent causes for impaired remyelination in MS
Heß, Katharina, Starost, Laura, Kieran, Nicholas W., Thomas, Christian, Vincenten, Maria C. J., Antel, Jack, Martino, Gianvito, Huitinga, Inge, Healy, Luke, Kuhlmann, Tanja
Published in Acta neuropathologica (01.09.2020)
Published in Acta neuropathologica (01.09.2020)
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Central nervous system regeneration is driven by microglia necroptosis and repopulation
Lloyd, Amy F., Davies, Claire L., Holloway, Rebecca K., Labrak, Yasmine, Ireland, Graeme, Carradori, Dario, Dillenburg, Alessandra, Borger, Eva, Soong, Daniel, Richardson, Jill C., Kuhlmann, Tanja, Williams, Anna, Pollard, Jeffrey W., des Rieux, Anne, Priller, Josef, Miron, Veronique E.
Published in Nature neuroscience (01.07.2019)
Published in Nature neuroscience (01.07.2019)
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Achievements and obstacles of remyelinating therapies in multiple sclerosis
Stangel, Martin, Kuhlmann, Tanja, Matthews, Paul M., Kilpatrick, Trevor J.
Published in Nature reviews. Neurology (01.12.2017)
Published in Nature reviews. Neurology (01.12.2017)
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Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
Beuker, Carolin, Schafflick, David, Strecker, Jan-Kolja, Heming, Michael, Li, Xiaolin, Wolbert, Jolien, Schmidt-Pogoda, Antje, Thomas, Christian, Kuhlmann, Tanja, Aranda-Pardos, Irene, A-Gonzalez, Noelia, Kumar, Praveen Ashok, Werner, Yves, Kilic, Ertugrul, Hermann, Dirk M., Wiendl, Heinz, Stumm, Ralf, Meyer zu Hörste, Gerd, Minnerup, Jens
Published in Nature communications (17.02.2022)
Published in Nature communications (17.02.2022)
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Association between pathological and MRI findings in multiple sclerosis
Filippi, Massimo, Brück, Wolfgang, Chard, Declan, Fazekas, Franz, Geurts, Jeroen J G, Enzinger, Christian, Hametner, Simon, Kuhlmann, Tanja, Preziosa, Paolo, Rovira, Àlex, Schmierer, Klaus, Stadelmann, Christine, Rocca, Maria A
Published in Lancet neurology (01.02.2019)
Published in Lancet neurology (01.02.2019)
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G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators
Gurusamy, Malarvizhi, Tischner, Denise, Shao, Jingchen, Klatt, Stephan, Zukunft, Sven, Bonnavion, Remy, Günther, Stefan, Siebenbrodt, Kai, Kestner, Roxane-Isabelle, Kuhlmann, Tanja, Fleming, Ingrid, Offermanns, Stefan, Wettschureck, Nina
Published in Nature communications (23.11.2021)
Published in Nature communications (23.11.2021)
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Seeking neuroprotection in multiple sclerosis: an ongoing challenge
Antel, Jack P, Kennedy, Timothy E, Kuhlmann, Tanja
Published in The Journal of clinical investigation (03.04.2023)
Published in The Journal of clinical investigation (03.04.2023)
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Journal Article
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions
Fard, Maryam K, van der Meer, Franziska, Sánchez, Paula, Cantuti-Castelvetri, Ludovico, Mandad, Sunit, Jäkel, Sarah, Fornasiero, Eugenio F, Schmitt, Sebastian, Ehrlich, Marc, Starost, Laura, Kuhlmann, Tanja, Sergiou, Christina, Schultz, Verena, Wrzos, Claudia, Brück, Wolfgang, Urlaub, Henning, Dimou, Leda, Stadelmann, Christine, Simons, Mikael
Published in Science translational medicine (06.12.2017)
Published in Science translational medicine (06.12.2017)
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CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome
Gross, Catharina C., Meyer, Céline, Bhatia, Urvashi, Yshii, Lidia, Kleffner, Ilka, Bauer, Jan, Tröscher, Anna R., Schulte-Mecklenbeck, Andreas, Herich, Sebastian, Schneider-Hohendorf, Tilman, Plate, Henrike, Kuhlmann, Tanja, Schwaninger, Markus, Brück, Wolfgang, Pawlitzki, Marc, Laplaud, David-Axel, Loussouarn, Delphine, Parratt, John, Barnett, Michael, Buckland, Michael E., Hardy, Todd A., Reddel, Stephen W., Ringelstein, Marius, Dörr, Jan, Wildemann, Brigitte, Kraemer, Markus, Lassmann, Hans, Höftberger, Romana, Beltrán, Eduardo, Dornmair, Klaus, Schwab, Nicholas, Klotz, Luisa, Meuth, Sven G., Martin-Blondel, Guillaume, Wiendl, Heinz, Liblau, Roland
Published in Nature communications (18.12.2019)
Published in Nature communications (18.12.2019)
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Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression
Reinhardt, Peter, Schmid, Benjamin, Burbulla, Lena F., Schöndorf, David C., Wagner, Lydia, Glatza, Michael, Höing, Susanne, Hargus, Gunnar, Heck, Susanna A., Dhingra, Ashutosh, Wu, Guangming, Müller, Stephan, Brockmann, Kathrin, Kluba, Torsten, Maisel, Martina, Krüger, Rejko, Berg, Daniela, Tsytsyura, Yaroslav, Thiel, Cora S., Psathaki, Olympia-Ekaterini, Klingauf, Jürgen, Kuhlmann, Tanja, Klewin, Marlene, Müller, Heiko, Gasser, Thomas, Schöler, Hans R., Sterneckert, Jared
Published in Cell stem cell (07.03.2013)
Published in Cell stem cell (07.03.2013)
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Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity
Hucke, Stephanie, Eschborn, Melanie, Liebmann, Marie, Herold, Martin, Freise, Nicole, Engbers, Annika, Ehling, Petra, Meuth, Sven G, Roth, Johannes, Kuhlmann, Tanja, Wiendl, Heinz, Klotz, Luisa
Published in Journal of autoimmunity (01.02.2016)
Published in Journal of autoimmunity (01.02.2016)
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Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis
Starost, Laura, Lindner, Maren, Herold, Martin, Xu, Yu Kang T., Drexler, Hannes C. A., Heß, Katharina, Ehrlich, Marc, Ottoboni, Linda, Ruffini, Francesca, Stehling, Martin, Röpke, Albrecht, Thomas, Christian, Schöler, Hans R., Antel, Jack, Winkler, Jürgen, Martino, Gianvito, Klotz, Luisa, Kuhlmann, Tanja
Published in Acta neuropathologica (01.11.2020)
Published in Acta neuropathologica (01.11.2020)
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CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing
Schneider-Hohendorf, Tilman, Mohan, Hema, Bien, Christian G., Breuer, Johanna, Becker, Albert, Görlich, Dennis, Kuhlmann, Tanja, Widman, Guido, Herich, Sebastian, Elpers, Christiane, Melzer, Nico, Dornmair, Klaus, Kurlemann, Gerhard, Wiendl, Heinz, Schwab, Nicholas
Published in Nature communications (04.04.2016)
Published in Nature communications (04.04.2016)
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Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning
Weider, Matthias, Starost, Laura Julia, Groll, Katharina, Küspert, Melanie, Sock, Elisabeth, Wedel, Miriam, Fröb, Franziska, Schmitt, Christian, Baroti, Tina, Hartwig, Anna C., Hillgärtner, Simone, Piefke, Sandra, Fadler, Tanja, Ehrlich, Marc, Ehlert, Corinna, Stehling, Martin, Albrecht, Stefanie, Jabali, Ammar, Schöler, Hans R., Winkler, Jürgen, Kuhlmann, Tanja, Wegner, Michael
Published in Nature communications (02.03.2018)
Published in Nature communications (02.03.2018)
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Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration
Molina-Gonzalez, Irene, Holloway, Rebecca K., Jiwaji, Zoeb, Dando, Owen, Kent, Sarah A., Emelianova, Katie, Lloyd, Amy F., Forbes, Lindsey H., Mahmood, Ayisha, Skripuletz, Thomas, Gudi, Viktoria, Febery, James A., Johnson, Jeffrey A., Fowler, Jill H., Kuhlmann, Tanja, Williams, Anna, Chandran, Siddharthan, Stangel, Martin, Howden, Andrew J. M., Hardingham, Giles E., Miron, Veronique E.
Published in Nature communications (08.06.2023)
Published in Nature communications (08.06.2023)
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