Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-d]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry
Deng, Yijun, Zhou, Xilin, Kugel Desmoulin, Sita, Wu, Jianmei, Cherian, Christina, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem
Published in Journal of medicinal chemistry (14.05.2009)
Published in Journal of medicinal chemistry (14.05.2009)
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Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter
Kugel Desmoulin, Sita, Wang, Lei, Hales, Eric, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Cherian, Christina, Gangjee, Aleem, Matherly, Larry H
Published in Molecular pharmacology (01.12.2011)
Published in Molecular pharmacology (01.12.2011)
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Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter
Hou, Zhanjun, Kugel Desmoulin, Sita, Etnyre, Erika, Olive, Mary, Hsiung, Benjamin, Cherian, Christina, Wloszczynski, Patrick A., Moin, Kamiar, Matherly, Larry H.
Published in The Journal of biological chemistry (10.02.2012)
Published in The Journal of biological chemistry (10.02.2012)
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Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier
Wang, Lei, Cherian, Christina, Kugel Desmoulin, Sita, Mitchell-Ryan, Shermaine, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry
Wang, Lei, Cherian, Christina, Kugel Desmoulin, Sita, Polin, Lisa, Deng, Yijun, Wu, Jianmei, Hou, Zhanjun, White, Kathryn, Kushner, Juiwanna, Matherly, Larry H, Gangjee, Aleem
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter
Cherian, Christina, Kugel Desmoulin, Sita, Wang, Lei, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Gangjee, Aleem, Matherly, Larry H.
Published in Cancer chemotherapy and pharmacology (01.04.2013)
Published in Cancer chemotherapy and pharmacology (01.04.2013)
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The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
Desmoulin, Sita Kugel, Hou, Zhanjun, Gangjee, Aleem, Matherly, Larry H.
Published in Cancer biology & therapy (01.12.2012)
Published in Cancer biology & therapy (01.12.2012)
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Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase
Wang, Lei, Desmoulin, Sita Kugel, Cherian, Christina, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Fulterer, Andreas, Chang, Min-Hwang, Mitchell-Ryan, Shermaine, Stout, Mark, Romero, Michael F, Hou, Zhanjun, Matherly, Larry H, Gangjee, Aleem
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Abstract 783: Identification of structural determinants of human proton-coupled folate transporter oligomerization
Hou, Zhanjun, Wilson, M. Roy, Wilson, Lucas, Desmoulin, Sita Kugel, Huang, Jenny, Matherly, Larry H.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter
Desmoulin, Sita Kugel, Wang, Lei, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Cherian, Christina, Gangjee, Aleem, Matherly, Larry H
Published in Molecular pharmacology (01.10.2012)
Published in Molecular pharmacology (01.10.2012)
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The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
Larson Gedman, A, Chen, Q, Kugel Desmoulin, S, Ge, Y, LaFiura, K, Haska, C L, Cherian, C, Devidas, M, Linda, S B, Taub, J W, Matherly, L H
Published in Leukemia (01.08.2009)
Published in Leukemia (01.08.2009)
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Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors
Desmoulin, Sita Kugel, Wang, Yiqiang, Wu, Jianmei, Stout, Mark, Hou, Zhanjun, Fulterer, Andreas, Chang, Min-Hwang, Romero, Michael F, Cherian, Christina, Gangjee, Aleem, Matherly, Larry H
Published in Molecular pharmacology (01.10.2010)
Published in Molecular pharmacology (01.10.2010)
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The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
Zhanjun Hou, Aleem Gangjee, Larry H. Matherly, Sita Kugel Desmoulin
Published in Cancer biology & therapy (01.12.2012)
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Published in Cancer biology & therapy (01.12.2012)
Journal Article
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
Zhanjun Hou, Aleem Gangjee, Larry H. Matherly, Sita Kugel Desmoulin
Published in Cancer biology & therapy (01.12.2012)
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Published in Cancer biology & therapy (01.12.2012)
Journal Article
The human proton-coupled folate transporter: Biology and therapeutic applications to cancer
Zhanjun Hou, Aleem Gangjee, Larry H. Matherly, Sita Kugel Desmoulin
Published in Cancer biology & therapy (01.12.2012)
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Published in Cancer biology & therapy (01.12.2012)
Journal Article
Abstract 1364: Design, synthesis and evaluation of potent antiproliferative and cytotoxic antifolates with selective FRs and PCFT transport over RFC and potent GARFTase inhibition
Wang, Lei, Cherian, Christina, Desmoulin, Sita Kugel, Hou, Zhanjun, Matherly, Larry H., Gangjee, Aleem
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Abstract 3825: The impact of the reduced folate carrier on the collateral sensitivity of novel 6-substituted pyrrolo[2,3- d ]pyrimidine thienoyl antifolates with selective uptake by the proton-coupled folate transporter
Desmoulin, Sita Kugel, Wang, Lei, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Cherian, Christina, Gangjee, Aleem, Matherly, Larry H.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 3826: Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3- d ]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter
Cherian, Christina, Desmoulin, Sita Kugel, Wang, Lei, Polin, Lisa, White, Kathryn, Kushner, Juiwanna, Stout, Mark, Hou, Zhanjun, Gangjee, Aleem, Matherly, Larry H.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Abstract 2528: Therapeutic targeting of a novel 6-substituted pyrrolo[2,3- d ]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by PCFT
Desmoulin, Sita Kugel, Wang, Lei, Tait, Larry, Polin, Lisa, Hou, Zhanjun, Cherian, Christina, Gangjee, Aleem, Matherly, Larry H.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Abstract 3250: Design, synthesis and biological evaluation of side chain pemetrexed (PMX) analogues as potent inhibitors of tumors expressing folate receptors via GARFTase inhibition
Wang, Yiqiang, Mitchell, Shermaine, Cherian, Christina, Desmoulin, Sita Kugel, Hou, Zhanjun, Kisliuk, Roy L., Matherly, Larry H., Gangjee, Aleem
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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