JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction
Gelotte, Cathy K., Vakil, Amy M., Zimmerman, Brenda A., Zannikos, Peter, Mishra, Rajesh, Eichenbaum, Gary, Kuffner, Edwin K., Flores, Christopher M.
Published in Regulatory toxicology and pharmacology (23.08.2023)
Published in Regulatory toxicology and pharmacology (23.08.2023)
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Journal Article
Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses
Zhou, Junguo, De Jonghe, Sandra, Codd, Ellen E., Weiner, Sandy, Gallacher, David, Stahle, Paul, Kelley, Michael F., Kuffner, Edwin K., Flores, Christopher M., Eichenbaum, Gary E.
Published in Regulatory toxicology and pharmacology (04.01.2023)
Published in Regulatory toxicology and pharmacology (04.01.2023)
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Journal Article
First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen
Gelotte, Cathy K., Vakil, Amy M., Berwaerts, Joris, Zimmerman, Brenda A., Eichenbaum, Gary E., Flores, Christopher M., Kuffner, Edwin K.
Published in Regulatory toxicology and pharmacology (01.10.2022)
Published in Regulatory toxicology and pharmacology (01.10.2022)
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Journal Article
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans
Lim, Heng-Keang, Chen, Jie, Lam, Wing, Gong, Yong, Leclercq, Laurent, Silva, Jose, Salter, Rhys, Berwaerts, Joris, Gelotte, Cathy K., Vakil, Amy M., Eichenbaum, Gary E., Kuffner, Edwin K., Flores, Christopher M.
Published in Regulatory toxicology and pharmacology (16.03.2023)
Published in Regulatory toxicology and pharmacology (16.03.2023)
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Journal Article
Dosing and Antipyretic Efficacy of Oral Acetaminophen in Children
Temple, Anthony R., MD, Temple, Brigham R., MD, Kuffner, Edwin K., MD
Published in Clinical therapeutics (01.09.2013)
Published in Clinical therapeutics (01.09.2013)
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A Pilot Study Assessing Common Medication Organizers for Child-Resistant Features
Teum, Lilai, Gokhman, Fallon, Park, Sophia, Budnitz, Daniel S., Aquilina, Joseph W., Kuffner, Edwin K.
Published in AJPM Focus (01.08.2024)
Published in AJPM Focus (01.08.2024)
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Journal Article
Comparison of the Efficacy and Safety of 2 Acetaminophen Dosing Regimens in Febrile Infants and Children: A Report on 3 Legacy Studies
Temple, Anthony R, Zimmerman, Brenda, Gelotte, Cathy, Kuffner, Edwin K
Published in The journal of pediatric pharmacology and therapeutics (01.01.2017)
Published in The journal of pediatric pharmacology and therapeutics (01.01.2017)
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Journal Article
Retrospective analysis of transient elevations in alanine aminotransferase during long-term treatment with acetaminophen in osteoarthritis clinical trials
Kuffner, Edwin K., Temple, Anthony R., Cooper, Kimberly M., Baggish, Jeffrey S., Parenti, Dennis L.
Published in Current medical research and opinion (01.11.2006)
Published in Current medical research and opinion (01.11.2006)
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Journal Article
Low-Level Alanine Aminotransferase Elevations in Osteoarthritis Patients within Approximately 2 Weeks of Treatment Initiation with Daily Acetaminophen: A Retrospective Analysis Evaluating Subsequent Alanine Aminotransferase Activity on Continued Acetaminophen Therapy
Kuffner, Edwin K., Cooper, Kimberly M., Baggish, Jeffrey S., Lynch, Joseph M., Zimmerman, Brenda A., Bloom, Leslie A., Franklin, Kathleen B., Temple, Anthony R.
Published in Clinical Medicine Insights: Therapeutics (14.11.2013)
Published in Clinical Medicine Insights: Therapeutics (14.11.2013)
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Journal Article
Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential
Jaeschke, Hartmut, Murray, F. Jay, Monnot, Andrew D., Jacobson-Kram, David, Cohen, Samuel M., Hardisty, Jerry F., Atillasoy, Evren, Hermanowski-Vosatka, Anne, Kuffner, Edwin, Wikoff, Daniele, Chappell, Grace A., Bandara, Suren B., Deore, Milind, Pitchaiyan, Suresh Kumar, Eichenbaum, Gary
Published in Regulatory toxicology and pharmacology (01.03.2021)
Published in Regulatory toxicology and pharmacology (01.03.2021)
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Journal Article
Successful Treatment of Latrodectism with Antivenin after 90 Hours
O'Malley, Gerald F, Dart, Richard C, Kuffner, Edwin F
Published in The New England journal of medicine (25.02.1999)
Published in The New England journal of medicine (25.02.1999)
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Journal Article
Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen
Eichenbaum, Gary, Yang, Kyunghee, Gebremichael, Yeshitila, Howell, Brett A., Murray, F. Jay, Jacobson-Kram, David, Jaeschke, Hartmut, Kuffner, Edwin, Gelotte, Cathy K., Lai, John C.K., Wikoff, Daniele, Atillasoy, Evren
Published in Regulatory toxicology and pharmacology (01.12.2020)
Published in Regulatory toxicology and pharmacology (01.12.2020)
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Journal Article
A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential
Murray, F. Jay, Monnot, Andrew D., Jacobson-Kram, David, Cohen, Samuel M., Hardisty, Jerry F., Bandara, Suren B., Kovochich, Michael, Deore, Milind, Pitchaiyan, Suresh Kumar, Gelotte, Cathy K., Lai, John C.K., Atillasoy, Evren, Hermanowski-Vosatka, Anne, Kuffner, Edwin, Unice, Kenneth M., Yang, Kyunghee, Gebremichael, Yeshitila, Howell, Brett A., Eichenbaum, Gary
Published in Regulatory toxicology and pharmacology (01.12.2020)
Published in Regulatory toxicology and pharmacology (01.12.2020)
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Journal Article
New insights into root causes of pediatric accidental unsupervised ingestions of over-the-counter medications
Schoenewald, Sandy, Ross, Stacey, Bloom, Leslie, Shah, Megha, Lynch, Joseph, Lin, Changshuan Lily, Patel, Mitesh, Boyle, Kathleen, Kuffner, Edwin
Published in Clinical toxicology (Philadelphia, Pa.) (01.12.2013)
Published in Clinical toxicology (Philadelphia, Pa.) (01.12.2013)
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Journal Article
Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial
Kuffner, E K, Dart, R C, Bogdan, G M, Hill, R E, Casper, E, Darton, L
Published in Archives of internal medicine (1960) (08.10.2001)
Published in Archives of internal medicine (1960) (08.10.2001)
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Clinical policy: Critical issues in the evaluation and management of adult patients presenting with suspected pulmonary embolism
Published in Annals of emergency medicine
(01.02.2003)
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