Cysteine oxidation and disulfide formation in the ribosomal exit tunnel
Schulte, Linda, Mao, Jiafei, Reitz, Julian, Sreeramulu, Sridhar, Kudlinzki, Denis, Hodirnau, Victor-Valentin, Meier-Credo, Jakob, Saxena, Krishna, Buhr, Florian, Langer, Julian D., Blackledge, Martin, Frangakis, Achilleas S., Glaubitz, Clemens, Schwalbe, Harald
Published in Nature communications (04.11.2020)
Published in Nature communications (04.11.2020)
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Journal Article
Molecular tuning of farnesoid X receptor partial agonism
Merk, Daniel, Sreeramulu, Sridhar, Kudlinzki, Denis, Saxena, Krishna, Linhard, Verena, Gande, Santosh L., Hiller, Fabian, Lamers, Christina, Nilsson, Ewa, Aagaard, Anna, Wissler, Lisa, Dekker, Niek, Bamberg, Krister, Schubert-Zsilavecz, Manfred, Schwalbe, Harald
Published in Nature communications (02.07.2019)
Published in Nature communications (02.07.2019)
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Journal Article
Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells
Scharow, Andrej, Raab, Monika, Saxena, Krishna, Sreeramulu, Sridhar, Kudlinzki, Denis, Gande, Santosh, Dötsch, Christina, Kurunci-Csacsko, Elisabeth, Klaeger, Susan, Kuster, Bernhard, Schwalbe, Harald, Strebhardt, Klaus, Berg, Thorsten
Published in ACS chemical biology (20.11.2015)
Published in ACS chemical biology (20.11.2015)
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Journal Article
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs
Heinzlmeir, Stephanie, Kudlinzki, Denis, Sreeramulu, Sridhar, Klaeger, Susan, Gande, Santosh Lakshmi, Linhard, Verena, Wilhelm, Mathias, Qiao, Huichao, Helm, Dominic, Ruprecht, Benjamin, Saxena, Krishna, Médard, Guillaume, Schwalbe, Harald, Kuster, Bernhard
Published in ACS chemical biology (16.12.2016)
Published in ACS chemical biology (16.12.2016)
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Journal Article
Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22
Kudlinzki, Denis, Schmitt, Andreas, Christian, Henning, Ficner, Ralf
Published in Biological chemistry (01.10.2012)
Published in Biological chemistry (01.10.2012)
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Journal Article
Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma
DiPrima, Michael, Wang, Dunrui, Tröster, Alix, Maric, Dragan, Terrades‐Garcia, Nekane, Ha, Taekyu, Kwak, Hyeongil, Sanchez‐Martin, David, Kudlinzki, Denis, Schwalbe, Harald, Tosato, Giovanna
Published in Molecular oncology (01.11.2019)
Published in Molecular oncology (01.11.2019)
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Journal Article
Influence of Heparin Mimetics on Assembly of the FGF·FGFR4 Signaling Complex
Saxena, Krishna, Schieborr, Ulrich, Anderka, Oliver, Duchardt-Ferner, Elke, Elshorst, Bettina, Gande, Santosh Lakshmi, Janzon, Julia, Kudlinzki, Denis, Sreeramulu, Sridhar, Dreyer, Matthias K., Wendt, K. Ulrich, Herbert, Corentin, Duchaussoy, Philippe, Bianciotto, Marc, Driguez, Pierre-Alexandre, Lassalle, Gilbert, Savi, Pierre, Mohammadi, Moosa, Bono, Françoise, Schwalbe, Harald
Published in The Journal of biological chemistry (20.08.2010)
Published in The Journal of biological chemistry (20.08.2010)
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Journal Article
Cover Feature: Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor (Chem. Eur. J. 23/2023)
Tröster, Alix, DiPrima, Michael, Jores, Nathalie, Kudlinzki, Denis, Sreeramulu, Sridhar, Gande, Santosh L., Linhard, Verena, Ludig, Damian, Schug, Alexander, Saxena, Krishna, Reinecke, Maria, Heinzlmeir, Stephanie, Leisegang, Matthias S., Wollenhaupt, Jan, Lennartz, Frank, Weiss, Manfred S., Kuster, Bernhard, Tosato, Giovanna, Schwalbe, Harald
Published in Chemistry : a European journal (21.04.2023)
Published in Chemistry : a European journal (21.04.2023)
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Journal Article
Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor
Tröster, Alix, DiPrima, Michael, Jores, Nathalie, Kudlinzki, Denis, Sreeramulu, Sridhar, Gande, Santosh L., Linhard, Verena, Ludig, Damian, Schug, Alexander, Saxena, Krishna, Reinecke, Maria, Heinzlmeir, Stephanie, Leisegang, Matthias S., Wollenhaupt, Jan, Lennartz, Frank, Weiss, Manfred S., Kuster, Bernhard, Tosato, Giovanna, Schwalbe, Harald
Published in Chemistry : a European journal (21.04.2023)
Published in Chemistry : a European journal (21.04.2023)
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Journal Article
Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug–Kinase Binding
Wienen-Schmidt, Barbara, Jonker, Hendrik R. A, Wulsdorf, Tobias, Gerber, Hans-Dieter, Saxena, Krishna, Kudlinzki, Denis, Sreeramulu, Sridhar, Parigi, Giacomo, Luchinat, Claudio, Heine, Andreas, Schwalbe, Harald, Klebe, Gerhard
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Journal Article
Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling
Herbert, Corentin, Schieborr, Ulrich, Saxena, Krishna, Juraszek, Jarek, De Smet, Frederik, Alcouffe, Chantal, Bianciotto, Marc, Saladino, Giorgio, Sibrac, David, Kudlinzki, Denis, Sreeramulu, Sridhar, Brown, Alan, Rigon, Patrice, Herault, Jean-Pascal, Lassalle, Gilbert, Blundell, Tom L., Rousseau, Frederic, Gils, Ann, Schymkowitz, Joost, Tompa, Peter, Herbert, Jean-Marc, Carmeliet, Peter, Gervasio, Francesco Luigi, Schwalbe, Harald, Bono, Françoise
Published in Cancer cell (15.04.2013)
Published in Cancer cell (15.04.2013)
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Journal Article
The landscape of EPHA2 inhibition
Kudlinzki, Denis, Heinzlmeir, Stephanie, Kuster, Bernhard, Schwalbe, Harald
Published in Acta crystallographica. Section A, Foundations and advances (26.05.2017)
Published in Acta crystallographica. Section A, Foundations and advances (26.05.2017)
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Journal Article
Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding
Lehner, Florian, Kudlinzki, Denis, Richter, Christian, Müller‐Werkmeister, Henrike M., Eberl, Katharina B., Bredenbeck, Jens, Schwalbe, Harald, Silvers, Robert
Published in Chembiochem : a European journal of chemical biology (05.12.2017)
Published in Chembiochem : a European journal of chemical biology (05.12.2017)
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Journal Article
Chemoproteomics‐Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors
Heinzlmeir, Stephanie, Lohse, Jonas, Treiber, Tobias, Kudlinzki, Denis, Linhard, Verena, Gande, Santosh Lakshmi, Sreeramulu, Sridhar, Saxena, Krishna, Liu, Xiaofeng, Wilhelm, Mathias, Schwalbe, Harald, Kuster, Bernhard, Médard, Guillaume
Published in ChemMedChem (21.06.2017)
Published in ChemMedChem (21.06.2017)
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Journal Article
NVP‐BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family
Tröster, Alix, Heinzlmeir, Stephanie, Berger, Benedict‐Tilman, Gande, Santosh L., Saxena, Krishna, Sreeramulu, Sridhar, Linhard, Verena, Nasiri, Amir H., Bolte, Michael, Müller, Susanne, Kuster, Bernhard, Médard, Guillaume, Kudlinzki, Denis, Schwalbe, Harald
Published in ChemMedChem (20.08.2018)
Published in ChemMedChem (20.08.2018)
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Journal Article
Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina
Chatterjee, Deep, Kudlinzki, Denis, Linhard, Verena, Saxena, Krishna, Schieborr, Ulrich, Gande, Santosh L., Wurm, Jan Philip, Wöhnert, Jens, Abele, Rupert, Rogov, Vladimir V., Dötsch, Volker, Osiewacz, Heinz D., Sreeramulu, Sridhar, Schwalbe, Harald
Published in The Journal of biological chemistry (26.06.2015)
Published in The Journal of biological chemistry (26.06.2015)
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Journal Article
Cover Feature: Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding (ChemBioChem 23/2017)
Lehner, Florian, Kudlinzki, Denis, Richter, Christian, Müller‐Werkmeister, Henrike M., Eberl, Katharina B., Bredenbeck, Jens, Schwalbe, Harald, Silvers, Robert
Published in Chembiochem : a European journal of chemical biology (05.12.2017)
Published in Chembiochem : a European journal of chemical biology (05.12.2017)
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Journal Article
Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds
Raab, Monika, Sanhaji, Mourad, Pietsch, Larissa, Béquignon, Isabelle, Herbrand, Amanda K, Süß, Evelyn, Gande, Santosh L, Caspar, Birgit, Kudlinzki, Denis, Saxena, Krishna, Sreeramulu, Sridhar, Schwalbe, Harald, Strebhardt, Klaus, Biondi, Ricardo M
Published in ACS chemical biology (17.08.2018)
Published in ACS chemical biology (17.08.2018)
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Journal Article
On the Implication of Water on Fragment‐to‐Ligand Growth in Kinase Binding Thermodynamics
Wienen‐Schmidt, Barbara, Wulsdorf, Tobias, Jonker, Hendrik R. A., Saxena, Krishna, Kudlinzki, Denis, Linhard, Verena, Sreeramulu, Sridhar, Heine, Andreas, Schwalbe, Harald, Klebe, Gerhard
Published in ChemMedChem (19.09.2018)
Published in ChemMedChem (19.09.2018)
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Journal Article
Expression and Purification of EPHA2 Tyrosine Kinase Domain for Crystallographic and NMR Studies
Gande, Santosh L., Saxena, Krishna, Sreeramulu, Sridhar, Linhard, Verena, Kudlinzki, Denis, Heinzlmeir, Stephanie, Reichert, Andreas J., Skerra, Arne, Kuster, Bernhard, Schwalbe, Harald
Published in Chembiochem : a European journal of chemical biology (02.12.2016)
Published in Chembiochem : a European journal of chemical biology (02.12.2016)
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Journal Article