Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children
Drilon, Alexander, Laetsch, Theodore W, Kummar, Shivaani, DuBois, Steven G, Lassen, Ulrik N, Demetri, George D, Nathenson, Michael, Doebele, Robert C, Farago, Anna F, Pappo, Alberto S, Turpin, Brian, Dowlati, Afshin, Brose, Marcia S, Mascarenhas, Leo, Federman, Noah, Berlin, Jordan, El-Deiry, Wafik S, Baik, Christina, Deeken, John, Boni, Valentina, Nagasubramanian, Ramamoorthy, Taylor, Matthew, Rudzinski, Erin R, Meric-Bernstam, Funda, Sohal, Davendra P.S, Ma, Patrick C, Raez, Luis E, Hechtman, Jaclyn F, Benayed, Ryma, Ladanyi, Marc, Tuch, Brian B, Ebata, Kevin, Cruickshank, Scott, Ku, Nora C, Cox, Michael C, Hawkins, Douglas S, Hong, David S, Hyman, David M
Published in The New England journal of medicine (22.02.2018)
Published in The New England journal of medicine (22.02.2018)
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Journal Article
Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study
Mato, Anthony R, Shah, Nirav N, Jurczak, Wojciech, Cheah, Chan Y, Pagel, John M, Woyach, Jennifer A, Fakhri, Bita, Eyre, Toby A, Lamanna, Nicole, Patel, Manish R, Alencar, Alvaro, Lech-Maranda, Ewa, Wierda, William G, Coombs, Catherine C, Gerson, James N, Ghia, Paolo, Le Gouill, Steven, Lewis, David John, Sundaram, Suchitra, Cohen, Jonathon B, Flinn, Ian W, Tam, Constantine S, Barve, Minal A, Kuss, Bryone, Taylor, Justin, Abdel-Wahab, Omar, Schuster, Stephen J, Palomba, M Lia, Lewis, Katharine L, Roeker, Lindsey E, Davids, Matthew S, Tan, Xuan Ni, Fenske, Timothy S, Wallin, Johan, Tsai, Donald E, Ku, Nora C, Zhu, Edward, Chen, Jessica, Yin, Ming, Nair, Binoj, Ebata, Kevin, Marella, Narasimha, Brown, Jennifer R, Wang, Michael
Published in The Lancet (British edition) (06.03.2021)
Published in The Lancet (British edition) (06.03.2021)
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Journal Article
Larotrectinib Demonstrates CNS Efficacy in TRK Fusion-Positive Solid Tumors
Rosen, Ezra Y, Schram, Alison M, Young, Robert J, Schreyer, Mark W, Hechtman, Jaclyn F, Shu, Catherine A, Ku, Nora C, Hyman, David M, Drilon, Alexander
Published in JCO precision oncology (16.05.2019)
Published in JCO precision oncology (16.05.2019)
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Journal Article
BRUIN CLL-321: A Phase 3 Open-Label, Randomized Study of Pirtobrutinib Versus Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Trial in Progress)
Sharman, Jeff P., Jurczak, Wojciech, Coombs, Catherine C., Hill, Marisa, Wang, Denise, Ku, Nora C., Guntur, Ananya, Shahda, Safi, Leow, Ching Ching, Ghia, Paolo, Mato, Anthony R.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
A First-in-Human Phase 1 Study of Oral LOXO-338, a Selective BCL2 Inhibitor, in Patients with Advanced Hematologic Malignancies (Trial in Progress)
Alencar, Alvaro J., Roeker, Lindsey E., Hoffmann, Marc, Guru Murthy, Guru Subramanian, Patel, Vishalkumar, Ku, Nora C., Pauff, James M., Eyre, Toby A., Jurczak, Wojciech, Le Gouill, Steven
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
CLL-114 BRUIN CLL-321: A Phase 3 Open-Label, Randomized Study of Pirtobrutinib Versus Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in BTK Inhibitor–Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Trial in Progress)
Hill, Marisa, Sharman, Jeff P., Jurczak, Wojciech, Coombs, Catherine C., Wang, Denise, Ku, Nora C., Guntur, Ananya, Shahda, Safi, Leow, Ching Ching, Ghia, Paolo, Mato, Anthony R.
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Journal Article
Poster: CLL-114 BRUIN CLL-321: A Phase 3 Open-Label, Randomized Study of Pirtobrutinib Versus Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in BTK Inhibitor–Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Trial in Progress)
Hill, Marisa, Sharman, Jeff P., Jurczak, Wojciech, Coombs, Catherine C., Wang, Denise, Ku, Nora C., Guntur, Ananya, Shahda, Safi, Leow, Ching Ching, Ghia, Paolo, Mato, Anthony R.
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
Published in Clinical lymphoma, myeloma and leukemia (01.10.2022)
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Journal Article
Results from a First-in-Human, Proof-of-Concept Phase 1 Trial in Pretreated B-Cell Malignancies for Loxo-305, a Next-Generation, Highly Selective, Non-Covalent BTK Inhibitor
Mato, Anthony R., Flinn, Ian W., Pagel, John M., Brown, Jennifer R., Cheah, Chan Y., Coombs, Catherine C., Patel, Manish R., Rothenberg, S. Michael, Tsai, Donald E., Ku, Nora C., Wang, Michael L.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
LOXO-305, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated Mantle Cell Lymphoma, Waldenström’s Macroglobulinemia, and Other Non-Hodgkin Lymphomas: Results from the Phase 1/2 BRUIN Study
Wang, Michael, Shah, Nirav N., Alencar, Alvaro J., Gerson, James N., Patel, Manish R., Fakhri, Bita, Jurczak, Wojciech, Tan, Xuan Ni, Lewis, Katharine L, Fenske, Timothy S., Coombs, Catherine C., Flinn, Ian W., Lewis, David John, Le Gouill, Steven, Palomba, M. Lia, Woyach, Jennifer A., Pagel, John M., Lamanna, Nicole, Cohen, Jonathon B., Barve, Minal, Ghia, Paolo, Eyre, Toby A., Yin, Ming, Nair, Binoj, Tsai, Donald, Ku, Nora C., Mato, Anthony, Cheah, Chan Yoon
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
LOXO-305, A Next Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated CLL/SLL: Results from the Phase 1/2 BRUIN Study
Mato, Anthony R., Pagel, John M., Coombs, Catherine C., Shah, Nirav N., Lamanna, Nicole, Lech-Marańda, Ewa, Eyre, Toby A., Woyach, Jennifer A., Wierda, William G., Cheah, Chan Yoon, Roeker, Lindsey E, Patel, Manish R., Fakhri, Bita, Barve, Minal, Tam, Constantine S., Lewis, David John, Gerson, James N., Alencar, Alvaro J., Taylor, Justin, Abdel-Wahab, Omar, Ghia, Paolo, Schuster, Stephen J., Chen, Jessica, Nair, Binoj, Tsai, Donald, Ku, Nora C., Davids, Matthew S., Brown, Jennifer R, Jurczak, Wojciech
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Poster: CLL-039: Pirtobrutinib (LOXO-305), a Next-Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated CLL/SLL: Results from the Phase 1/2 BRUIN Study
Coombs, Catherine C., Pagel, John M., Shah, Nirav N., Lamanna, Nicole, Lech-Maranda, Ewa, Eyre, Toby A., Woyach, Jennifer A., Wierda, William G, Cheah, Chan Y., Roeker, Lindsey, Patel, Manish R., Fakhri, Bita, Barve, Minal A., Tam, Constantine S., Lewis, David J., Gerson, James N., Alencar, Alvaro, Taylor, Justin, Abdel-Wahab, Omar, Ghia, Paolo, Schuster, Stephen J., Chen, Jessica, Nair, Binoj, Tsai, Donald E., Ku, Nora C., Davids, Matthew S., Brown, Jennifer R., Jurczak, Wojciech, Mato, Anthony R.
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
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Journal Article
Oral Abstract: CLL-039: Pirtobrutinib (LOXO-305), a Next-Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated CLL/SLL: Results from the Phase 1/2 BRUIN Study
Coombs, Catherine C., Pagel, John M., Shah, Nirav N., Lamanna, Nicole, Lech-Maranda, Ewa, Eyre, Toby A., Woyach, Jennifer A., Wierda, William G, Cheah, Chan Y., Roeker, Lindsey, Patel, Manish R., Fakhri, Bita, Barve, Minal A., Tam, Constantine S., Lewis, David J., Gerson, James N., Alencar, Alvaro, Taylor, Justin, Abdel-Wahab, Omar, Ghia, Paolo, Schuster, Stephen J., Chen, Jessica, Nair, Binoj, Tsai, Donald E., Ku, Nora C., Davids, Matthew S., Brown, Jennifer R., Jurczak, Wojciech, Mato, Anthony R.
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
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Journal Article
CLL-039: Pirtobrutinib (LOXO-305), a Next-Generation, Highly Selective, Non-Covalent BTK Inhibitor in Previously Treated CLL/SLL: Results from the Phase 1/2 BRUIN Study
Coombs, Catherine C., Pagel, John M., Shah, Nirav N., Lamanna, Nicole, Lech-Maranda, Ewa, Eyre, Toby A., Woyach, Jennifer A., Wierda, William G, Cheah, Chan Y., Roeker, Lindsey, Patel, Manish R., Fakhri, Bita, Barve, Minal A., Tam, Constantine S., Lewis, David J., Gerson, James N., Alencar, Alvaro, Taylor, Justin, Abdel-Wahab, Omar, Ghia, Paolo, Schuster, Stephen J., Chen, Jessica, Nair, Binoj, Tsai, Donald E., Ku, Nora C., Davids, Matthew S., Brown, Jennifer R., Jurczak, Wojciech, Mato, Anthony R.
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
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Journal Article
Poster: ABCL-040: Pirtobrutinib (LOXO-305), a Next-Generation, Highly Selective, Non-Covalent Bruton’s Tyrosine Kinase Inhibitor in Previously Treated Mantle Cell Lymphoma and Other Non-Hodgkin Lymphomas: Phase 1/2 BRUIN Study Results
Cohen, Jonathon B., Shah, Nirav N., Alencar, Alvaro J., Gerson, James N., Patel, Manish R., Fahkri, Bita, Jurczak, Wojciech, Tan, Xuan N., Lewis, Katharine L., Fenske, Timothy S., Coombs, Catherine C., Flinn, Ian, Lewis, David J., Gouill, Stephen Le, Palomba, M Lia, Woyach, Jennifer A., Pagel, John M., Lamanna, Nicole, Barve, Minal A., Ghia, Paolo, Eyre, Toby A., Yin, Ming, Nair, Binoj, Tsai, Donald E., Ku, Nora C., Mato, Anthony R., Cheah, Chan Y., Wang, Michael L.
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
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Journal Article
The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers
Hyman, David Michael, Laetsch, Theodore Willis, Kummar, Shivaani, DuBois, Steven G., Farago, Anna F., Pappo, Alberto S., Demetri, George D., El-Deiry, Wafik S., Lassen, Ulrik Niels, Dowlati, Afshin, Brose, Marcia S., Boni, Valentina, Turpin, Brian, Nagasubramanian, Ramamoorthy, Cruickshank, Scott, Cox, Michael Craig, Ku, Nora C., Hawkins, Douglas S., Hong, David S., Drilon, Alexander E.
Published in Journal of clinical oncology (20.06.2017)
Published in Journal of clinical oncology (20.06.2017)
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Journal Article
The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers
Hyman, David Michael, Laetsch, Theodore Willis, Kummar, Shivaani, DuBois, Steven G., Farago, Anna F., Pappo, Alberto S., Demetri, George D., El-Deiry, Wafik S., Lassen, Ulrik Niels, Dowlati, Afshin, Brose, Marcia S., Boni, Valentina, Turpin, Brian, Nagasubramanian, Ramamoorthy, Cruickshank, Scott, Cox, Michael Craig, Ku, Nora C., Hawkins, Douglas S., Hong, David S., Drilon, Alexander E.
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
ABCL-040: Pirtobrutinib (LOXO-305), a Next-Generation, Highly Selective, Non-Covalent Bruton's Tyrosine Kinase Inhibitor in Previously Treated Mantle Cell Lymphoma and Other Non-Hodgkin Lymphomas: Phase 1/2 BRUIN Study Results
Cohen, Jonathon B., Shah, Nirav N., Alencar, Alvaro J., Gerson, James N., Patel, Manish R., Fahkri, Bita, Jurczak, Wojciech, Tan, Xuan N., Lewis, Katharine L., Fenske, Timothy S., Coombs, Catherine C., Flinn, Ian, Lewis, David J., Gouill, Stephen Le, Palomba, M Lia, Woyach, Jennifer A., Pagel, John M., Lamanna, Nicole, Barve, Minal A., Ghia, Paolo, Eyre, Toby A., Yin, Ming, Nair, Binoj, Tsai, Donald E., Ku, Nora C., Mato, Anthony R., Cheah, Chan Y., Wang, Michael L.
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2021)
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Abstract CT138: Pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in combination with venetoclax ± rituximab in relapsed/refractory chronic lymphocytic leukemia: Results from the BRUIN phase 1b study
Roeker, Lindsey E., Mato, Anthony R., Brown, Jennifer R., Coombs, Catherine C., Shah, Nirav N., Wierda, William G., Patel, Manish R., Lewis, Katharine L., Balbas, Minna, Zhao, Junjie, Ku, Nora C., Kherani, Jennifer F., Tsai, Donald E., Nair, Binoj, Cheah, Chan Y.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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