Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1
Nawrocka, Daria, Krzyscik, Mateusz Adam, Sluzalska, Katarzyna Dominika, Otlewski, Jacek
Published in International journal of molecular sciences (01.06.2023)
Published in International journal of molecular sciences (01.06.2023)
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Journal Article
Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers
Porębska, Natalia, Knapik, Agata, Poźniak, Marta, Krzyścik, Mateusz Adam, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz
Published in Biomacromolecules (13.12.2021)
Published in Biomacromolecules (13.12.2021)
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FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization
Pozniak, Marta, Sokolowska‐Wedzina, Aleksandra, Jastrzebski, Kamil, Szymczyk, Jakub, Porebska, Natalia, Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Miaczynska, Marta, Otlewski, Jacek, Opalinski, Lukasz
Published in Molecular oncology (01.09.2020)
Published in Molecular oncology (01.09.2020)
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The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells
Poźniak, Marta, Porębska, Natalia, Krzyścik, Mateusz Adam, Sokołowska-Wędzina, Aleksandra, Jastrzębski, Kamil, Sochacka, Martyna, Szymczyk, Jakub, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz
Published in Molecular medicine (Cambridge, Mass.) (07.05.2021)
Published in Molecular medicine (Cambridge, Mass.) (07.05.2021)
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The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases
Poźniak, Marta, Żukowska, Dominika, Gędaj, Aleksandra, Krzyścik, Mateusz Adam, Porębska, Natalia, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz
Published in International journal of molecular sciences (31.07.2022)
Published in International journal of molecular sciences (31.07.2022)
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Journal Article
Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors
Poźniak, Marta, PorÄbska, Natalia, JastrzÄbski, Kamil, KrzyÅcik, Mateusz Adam, KuciÅska, Marika, Zarzycka, Weronika, Barbach, Agnieszka, Zakrzewska, MaÅgorzata, Otlewski, Jacek, MiÄczyÅska, Marta, OpaliÅski, Åukasz
Published in Journal of biomedical science (11.10.2021)
Published in Journal of biomedical science (11.10.2021)
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Journal Article
Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors
Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Sørensen, Vigdis, Sokolowska-Wedzina, Aleksandra, Lobocki, Michal, Swiderska, Karolina Weronika, Krowarsch, Daniel, Wiedlocha, Antoni, Otlewski, Jacek
Published in ACS omega (31.07.2017)
Published in ACS omega (31.07.2017)
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Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1)
Krzyscik, Mateusz Adam, Zakrzewska, Małgorzata, Otlewski, Jacek
Published in Molecular pharmaceutics (06.07.2020)
Published in Molecular pharmaceutics (06.07.2020)
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Journal Article
Methotrexate and epirubicin conjugates as potential antitumor drugs
Kmiecik, Szymon Wojciech, Krzyścik, Mateusz Adam, Filip-Psurska, Beata, Wietrzyk, Joanna, Boratyński, Janusz, Goszczyński, Tomasz Marek
Published in Postȩpy higieny i medycyny doświadczalnej (30.07.2017)
Published in Postȩpy higieny i medycyny doświadczalnej (30.07.2017)
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Drug Conjugation via Maleimide–Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies
Jendryczko, Karolina, Rzeszotko, Jakub, Krzyscik, Mateusz Adam, Kocyła, Anna, Szymczyk, Jakub, Otlewski, Jacek, Szlachcic, Anna
Published in Molecular pharmaceutics (02.05.2022)
Published in Molecular pharmaceutics (02.05.2022)
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Journal Article
Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1
Porebska, Natalia, Pozniak, Marta, Krzyscik, Mateusz Adam, Knapik, Agata, Czyrek, Aleksandra, Kucinska, Marika, Jastrzebski, Kamil, Zakrzewska, Malgorzata, Otlewski, Jacek, Opalinski, Lukasz
Published in International journal of biological macromolecules (01.06.2021)
Published in International journal of biological macromolecules (01.06.2021)
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Journal Article
Nanodiamonds as “artificial proteins”: Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals
Balek, Lukas, Buchtova, Marcela, Kunova Bosakova, Michaela, Varecha, Miroslav, Foldynova-Trantirkova, Silvie, Gudernova, Iva, Vesela, Iva, Havlik, Jan, Neburkova, Jitka, Turner, Stuart, Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Klimaschewski, Lars, Claus, Peter, Trantirek, Lukas, Cigler, Petr, Krejci, Pavel
Published in Biomaterials (01.09.2018)
Published in Biomaterials (01.09.2018)
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Journal Article
Fibroblast growth factor 2 conjugated with monomethyl auristatin E inhibits tumor growth in a mouse model
Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Sørensen, Vigdis, Øy, Geir Frode, Bruheim, Skjalg, Haugsten, Ellen Margrethe, Mælandsmo, Gunhild Mari, Wiedlocha, Antoni, Otlewski, Jacek
Published in Biomacromolecules (2021)
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Published in Biomacromolecules (2021)
Journal Article
Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model
Krzyscik, Mateusz A, Zakrzewska, Malgorzata, Sørensen, Vigdis, Øy, Geir Frode, Brunheim, Skjalg, Haugsten, Ellen M, Mælandsmo, Gunhild M, Wiedlocha, Antoni, Otlewski, Jacek
Published in Biomacromolecules (11.10.2021)
Published in Biomacromolecules (11.10.2021)
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Journal Article
Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation
Krzyscik, Mateusz Adam, Sokolowska-Wedzina, Aleksandra, Jendryczko, Karolina, Pozniak, Marta, Nawrocka, Daria, Porebska, Natalia, Zakrzewska, Malgorzata, Otlewski, Jacek, Szlachcic, Anna, Opalinski, Lukasz
Published in Journal of visualized experiments (05.01.2021)
Published in Journal of visualized experiments (05.01.2021)
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