Distinct localization of chiral proofreaders resolves organellar translation conflict in plants
Kumar, Pradeep, Babu, Kandhalu Sagadevan Dinesh, Singh, Avinash Kumar, Singh, Dipesh Kumar, Nalli, Aswan, Mukul, Shivapura Jagadeesha, Roy, Ankit, Mazeed, Mohd, Raman, Bakthisaran, Kruparani, Shobha P, Siddiqi, Imran, Sankaranarayanan, Rajan
Published in Proceedings of the National Academy of Sciences - PNAS (13.06.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (13.06.2023)
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Journal Article
Design principles and functional basis of enantioselectivity of alanyl-tRNA synthetase and a chiral proofreader during protein biosynthesis
Sivakumar, Koushick, Venkadasamy, Vinitha Lakshmi, Amudhan, Gurumoorthy, Ann, Kezia J, Goud, Gadela Karteek, Nayani, Kiranmai, Gogoi, Jotin, Kuncha, Santosh Kumar, Mainkar, Prathama S, Kruparani, Shobha P, Sankaranarayanan, Rajan
Published in Nucleic acids research (24.04.2023)
Published in Nucleic acids research (24.04.2023)
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Journal Article
A translation proofreader of archaeal origin imparts multi-aldehyde stress tolerance to land plants
Kumar, Pradeep, Roy, Ankit, Mukul, Shivapura Jagadeesha, Singh, Avinash Kumar, Singh, Dipesh Kumar, Nalli, Aswan, Banerjee, Pujaita, Babu, Kandhalu Sagadevan Dinesh, Raman, Bakthisaran, Kruparani, Shobha P, Siddiqi, Imran, Sankaranarayanan, Rajan
Published in eLife (19.02.2024)
Published in eLife (19.02.2024)
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Journal Article
Elongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA Deacylase
Routh, Satya Brata, Pawar, Komal Ishwar, Ahmad, Sadeem, Singh, Swati, Suma, Katta, Kumar, Mantu, Kuncha, Santosh Kumar, Yadav, Kranthikumar, Kruparani, Shobha P, Sankaranarayanan, Rajan
Published in PLoS biology (01.05.2016)
Published in PLoS biology (01.05.2016)
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Journal Article
Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS
Pawar, Komal Ishwar, Suma, Katta, Seenivasan, Ayshwarya, Kuncha, Santosh Kumar, Routh, Satya Brata, Kruparani, Shobha P, Sankaranarayanan, Rajan
Published in eLife (31.03.2017)
Published in eLife (31.03.2017)
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Journal Article
Mechanistic insights into cognate substrate discrimination during proofreading in translation
Hussain, Tanweer, Kamarthapu, Venu, Kruparani, Shobha P., Deshmukh, Mandar V., Sankaranarayanan, Rajan, Fersht, Alan R.
Published in Proceedings of the National Academy of Sciences - PNAS (21.12.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (21.12.2010)
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Journal Article
Specificity and catalysis hardwired at the RNA–protein interface in a translational proofreading enzyme
Ahmad, Sadeem, Muthukumar, Sowndarya, Kuncha, Santosh Kumar, Routh, Satya Brata, Yerabham, Antony S.K., Hussain, Tanweer, Kamarthapu, Venu, Kruparani, Shobha P, Sankaranarayanan, Rajan
Published in Nature communications (26.06.2015)
Published in Nature communications (26.06.2015)
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Journal Article
A discriminator code-based DTD surveillance ensures faithful glycine delivery for protein biosynthesis in bacteria
Kuncha, Santosh Kumar, Suma, Katta, Pawar, Komal Ishwar, Gogoi, Jotin, Routh, Satya Brata, Pottabathini, Sambhavi, Kruparani, Shobha P, Sankaranarayanan, Rajan
Published in eLife (09.08.2018)
Published in eLife (09.08.2018)
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Journal Article
Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia
Kuncha, Santosh Kumar, Venkadasamy, Vinitha Lakshmi, Amudhan, Gurumoorthy, Dahate, Priyanka, Kola, Sankara Rao, Pottabathini, Sambhavi, Kruparani, Shobha P, Shekar, P Chandra, Sankaranarayanan, Rajan
Published in eLife (28.05.2020)
Published in eLife (28.05.2020)
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Journal Article
Mechanism of chiral proofreading during translation of the genetic code
Ahmad, Sadeem, Routh, Satya Brata, Kamarthapu, Venu, Chalissery, Jisha, Muthukumar, Sowndarya, Hussain, Tanweer, Kruparani, Shobha P, Deshmukh, Mandar V, Sankaranarayanan, Rajan
Published in eLife (03.12.2013)
Published in eLife (03.12.2013)
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Journal Article
Chiral checkpoints during protein biosynthesis
Kuncha, Santosh Kumar, Kruparani, Shobha P., Sankaranarayanan, Rajan
Published in The Journal of biological chemistry (08.11.2019)
Published in The Journal of biological chemistry (08.11.2019)
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Journal Article
Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea
Hussain, Tanweer, Kruparani, Shobha P, Pal, Biswajit, Dock-Bregeon, Anne-Catherine, Dwivedi, Shweta, Shekar, Megala R, Sureshbabu, Kotini, Sankaranarayanan, Rajan
Published in The EMBO journal (06.09.2006)
Published in The EMBO journal (06.09.2006)
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Journal Article
Recruitment of archaeal DTD is a key event toward the emergence of land plants
Mazeed, Mohd, Singh, Raghvendra, Kumar, Pradeep, Roy, Ankit, Raman, Bakthisaran, Kruparani, Shobha P, Sankaranarayanan, Rajan
Published in Science advances (01.02.2021)
Published in Science advances (01.02.2021)
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Journal Article
Switching a conflicted bacterial DTD-tRNA code is essential for the emergence of mitochondria
Gogoi, Jotin, Bhatnagar, Akshay, Ann, Kezia J, Pottabathini, Sambhavi, Singh, Raghvendra, Mazeed, Mohd, Kuncha, Santosh Kumar, Kruparani, Shobha P, Sankaranarayanan, Rajan
Published in Science advances (14.01.2022)
Published in Science advances (14.01.2022)
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Journal Article
A D -amino acid editing module coupled to the translational apparatus in archaea
Sankaranarayanan, Rajan, Dwivedi, Shweta, Kruparani, Shobha P
Published in Nature structural & molecular biology (01.06.2005)
Published in Nature structural & molecular biology (01.06.2005)
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Journal Article
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analyses of threonyl-tRNA synthetase editing domain from Aeropyrum pernix
Ahmad, Sadeem, Sravankumar, Antony S. K., Kruparani, Shobha P., Sankaranarayanan, Rajan
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.11.2012)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.11.2012)
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Journal Article
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic investigations of a unique editing domain from archaebacteria
Dwivedi, Shweta, Kruparani, Shobha P., Sankaranarayanan, Rajan
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2004)
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2004)
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Journal Article
A translation proofreader of archaeal origin imparts multi-aldehyde stress tolerance to land plants
Kumar, Pradeep, Roy, Ankit, Mukul, Shivapura Jagadeesha, Singh, Avinash Kumar, Singh, Dipesh Kumar, Nalli, Aswan, Banerjee, Pujaita, Babu, Kandhalu Sagadevan Dinesh, Raman, Bakthisaran, Kruparani, Shobha P, Siddiqi, Imran, Sankaranarayanan, Rajan
Published in eLife (19.02.2024)
Published in eLife (19.02.2024)
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Journal Article
Mechanistic insights into chiral proofreading during translation of genetic code
Routh, Satya Brata, Pawar, Komal Ishwar, Suma, Katta, Kumar, Mantu, Kruparani, Shobha P., Sankaranarayanan, Rajan
Published in Acta crystallographica. Section A, Foundations and advances (01.12.2017)
Published in Acta crystallographica. Section A, Foundations and advances (01.12.2017)
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Journal Article
D -Chiral specificity of archaeal and cyanobacterial D -aminoacyl-tRNA deacylases
Mazeed, Mohd, Kuncha, Santosh Kumar, Routh, Satya Brata, Kruparani, Shobha P., Sankaranarayanan, Rajan
Published in Acta crystallographica. Section A, Foundations and advances (01.12.2017)
Published in Acta crystallographica. Section A, Foundations and advances (01.12.2017)
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Journal Article