Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
Baccelli, Irène, Gareau, Yves, Lehnertz, Bernhard, Gingras, Stéphane, Spinella, Jean-François, Corneau, Sophie, Mayotte, Nadine, Girard, Simon, Frechette, Mélanie, Blouin-Chagnon, Valérie, Leveillé, Koryne, Boivin, Isabel, MacRae, Tara, Krosl, Jana, Thiollier, Clarisse, Lavallée, Vincent-Philippe, Kanshin, Evgeny, Bertomeu, Thierry, Coulombe-Huntington, Jasmin, St-Denis, Corinne, Bordeleau, Marie-Eve, Boucher, Geneviève, Roux, Philippe P., Lemieux, Sébastien, Tyers, Mike, Thibault, Pierre, Hébert, Josée, Marinier, Anne, Sauvageau, Guy
Published in Cancer cell (08.07.2019)
Published in Cancer cell (08.07.2019)
Get full text
Journal Article
The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
Lavallée, Vincent-Philippe, Baccelli, Irène, Krosl, Jana, Wilhelm, Brian, Barabé, Frédéric, Gendron, Patrick, Boucher, Geneviève, Lemieux, Sébastien, Marinier, Anne, Meloche, Sylvain, Hébert, Josée, Sauvageau, Guy
Published in Nature genetics (01.09.2015)
Published in Nature genetics (01.09.2015)
Get full text
Journal Article
Genetic characterization of ABT-199 sensitivity in human AML
Bisaillon, Richard, Moison, Céline, Thiollier, Clarisse, Krosl, Jana, Bordeleau, Marie-Eve, Lehnertz, Bernhard, Lavallée, Vincent-Philippe, MacRae, Tara, Mayotte, Nadine, Labelle, Caroline, Boucher, Geneviève, Spinella, Jean-François, Boivin, Isabel, D’Angelo, Giovanni, Lavallée, Sylvie, Marinier, Anne, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy
Published in Leukemia (01.01.2020)
Published in Leukemia (01.01.2020)
Get full text
Journal Article
Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
Lavallée, Vincent-Philippe, Krosl, Jana, Lemieux, Sébastien, Boucher, Geneviève, Gendron, Patrick, Pabst, Caroline, Boivin, Isabel, Marinier, Anne, Guidos, Cynthia J., Meloche, Sylvain, Hébert, Josée, Sauvageau, Guy
Published in Blood (16.06.2016)
Published in Blood (16.06.2016)
Get full text
Journal Article
The methyltransferase G9a regulates HoxA9-dependent transcription in AML
Lehnertz, Bernhard, Pabst, Caroline, Su, Le, Miller, Michelle, Liu, Feng, Yi, Lin, Zhang, Regan, Krosl, Jana, Yung, Eric, Kirschner, Jeanette, Rosten, Patty, Underhill, T Michael, Jin, Jian, Hébert, Josée, Sauvageau, Guy, Humphries, R Keith, Rossi, Fabio M
Published in Genes & development (15.02.2014)
Published in Genes & development (15.02.2014)
Get full text
Journal Article
Chemogenomic Landscape of RUNX1 -mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
Simon, Laura, Lavallée, Vincent-Philippe, Bordeleau, Marie-Eve, Krosl, Jana, Baccelli, Irène, Boucher, Geneviève, Lehnertz, Bernhard, Chagraoui, Jalila, MacRae, Tara, Ruel, Réjean, Chantigny, Yves, Lemieux, Sébastien, Marinier, Anne, Hébert, Josée, Sauvageau, Guy
Published in Clinical cancer research (15.11.2017)
Published in Clinical cancer research (15.11.2017)
Get full text
Journal Article
RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity
Cellot, Sonia, Hope, Kristin J., Chagraoui, Jalila, Sauvageau, Martin, Deneault, Éric, MacRae, Tara, Mayotte, Nadine, Wilhelm, Brian T., Landry, Josette R., Ting, Stephen B., Krosl, Jana, Humphries, Keith, Thompson, Alexander, Sauvageau, Guy
Published in Blood (29.08.2013)
Published in Blood (29.08.2013)
Get full text
Journal Article
Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway
Heinonen, Krista M, Vanegas, Juan Ruiz, Lew, Deborah, Krosl, Jana, Perreault, Claude
Published in PloS one (26.04.2011)
Published in PloS one (26.04.2011)
Get full text
Journal Article
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
Sauvageau, Guy, Krosl, Jana, Austin, Pamela, Beslu, Nathalie, Kroon, Evert, Humphries, R Keith
Published in Nature medicine (01.11.2003)
Published in Nature medicine (01.11.2003)
Get full text
Journal Article
Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene‐Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia
Ramsey, Joanne M., Kettyle, Laura M.J., Sharpe, Daniel J., Mulgrew, Nuala M., Dickson, Glenda J., Bijl, Janet J., Austin, Pamela, Mayotte, Nadine, Cellot, Sonia, Lappin, Terence R.J., Zhang, Shu‐Dong, Mills, Ken I., Krosl, Jana, Sauvageau, Guy, Thompson, Alexander
Published in Stem cells (Dayton, Ohio) (01.07.2013)
Published in Stem cells (Dayton, Ohio) (01.07.2013)
Get full text
Journal Article
Molecular interactions involved in HOXB4-induced activation of HSC self-renewal
Beslu, Nathalie, Krosl, Jana, Laurin, Mélanie, Mayotte, Nadine, Humphries, Keith R., Sauvageau, Guy
Published in Blood (15.10.2004)
Published in Blood (15.10.2004)
Get full text
Journal Article
Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions
Fortier, Simon, Bilodeau, Mélanie, Macrae, Tara, Laverdure, Jean-Philippe, Azcoitia, Valeria, Girard, Simon, Chagraoui, Jalila, Ringuette, Nancy, Hébert, Josée, Krosl, Jana, Mayotte, Nadine, Sauvageau, Guy
Published in PLoS genetics (01.12.2010)
Published in PLoS genetics (01.12.2010)
Get full text
Journal Article
Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1
KROSL, J, BABAN, S, KROSL, G, ROZENFELD, S, LARGMAN, C, SAUVAGEAU, G
Published in Oncogene (02.07.1998)
Published in Oncogene (02.07.1998)
Get full text
Journal Article
The Competitive Nature of HOXB4-Transduced HSC Is Limited by PBX1
Krosl, Jana, Beslu, Nathalie, Mayotte, Nadine, Humphries, R.Keith, Sauvageau, Guy
Published in Immunity (Cambridge, Mass.) (01.04.2003)
Published in Immunity (Cambridge, Mass.) (01.04.2003)
Get full text
Journal Article
GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
Pabst, Caroline, Bergeron, Anne, Lavallée, Vincent-Philippe, Yeh, Jonathan, Gendron, Patrick, Norddahl, Gudmundur L., Krosl, Jana, Boivin, Isabel, Deneault, Eric, Simard, Jessica, Imren, Suzan, Boucher, Geneviève, Eppert, Kolja, Herold, Tobias, Bohlander, Stefan K., Humphries, Keith, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy, Barabé, Frédéric
Published in Blood (21.04.2016)
Published in Blood (21.04.2016)
Get full text
Journal Article
Identification of small molecules that support human leukemia stem cell activity ex vivo
Pabst, Caroline, Krosl, Jana, Fares, Iman, Boucher, Geneviève, Ruel, Réjean, Marinier, Anne, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy
Published in Nature methods (01.04.2014)
Published in Nature methods (01.04.2014)
Get full text
Journal Article
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
Simon, Camille, Chagraoui, Jalila, Krosl, Jana, Gendron, Patrick, Wilhelm, Brian, Lemieux, Sébastien, Boucher, Geneviève, Chagnon, Pierre, Drouin, Simon, Lambert, Raphaëlle, Rondeau, Claude, Bilodeau, Annie, Lavallée, Sylvie, Sauvageau, Martin, Hébert, Josée, Sauvageau, Guy
Published in Genes & development (01.04.2012)
Published in Genes & development (01.04.2012)
Get full text
Journal Article
Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin
Lavallée, Vincent-Philippe, Chagraoui, Jalila, MacRae, Tara, Marquis, Miriam, Bonnefoy, Arnaud, Krosl, Jana, Lemieux, Sébastien, Marinier, Anne, Pabst, Caroline, Rivard, Georges-Étienne, Hébert, Josée, Sauvageau, Guy
Published in Leukemia (01.06.2018)
Published in Leukemia (01.06.2018)
Get full text
Journal Article