Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo
Kordus, Shannon L, Kroh, Heather K, Rodríguez, Rubén Cano, Shrem, Rebecca A, Peritore-Galve, F Christopher, Shupe, John A, Wadzinski, Brian E, Lacy, D Borden, Spiller, Benjamin W
Published in PLoS pathogens (23.10.2023)
Published in PLoS pathogens (23.10.2023)
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In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation
Panizzi, Peter, Nahrendorf, Matthias, Figueiredo, Jose-Luiz, Panizzi, Jennifer, Marinelli, Brett, Iwamoto, Yoshiko, Keliher, Edmund, Maddur, Ashoka A, Waterman, Peter, Kroh, Heather K, Leuschner, Florian, Aikawa, Elena, Swirski, Filip K, Pittet, Mikael J, Hackeng, Tilman M, Fuentes-Prior, Pablo, Schneewind, Olaf, Bock, Paul E, Weissleder, Ralph
Published in Nature medicine (01.09.2011)
Published in Nature medicine (01.09.2011)
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The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling
Ng, Victoria H, Spencer, Zachary, Neitzel, Leif R, Nayak, Anmada, Loberg, Matthew A, Shen, Chen, Kassel, Sara N, Kroh, Heather K, An, Zhenyi, Anthony, Christin C, Bryant, Jamal M, Lawson, Amanda, Goldsmith, Lily, Benchabane, Hassina, Hansen, Amanda G, Li, Jingjing, D'Souza, Starina, Lebensohn, Andres M, Rohatgi, Rajat, Weiss, William A, Weiss, Vivian L, Williams, Charles, Hong, Charles C, Robbins, David J, Ahmed, Yashi, Lee, Ethan
Published in Nature communications (05.10.2023)
Published in Nature communications (05.10.2023)
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Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab
Hernandez, Lorraine D., Kroh, Heather K., Hsieh, Edward, Yang, Xiaoyu, Beaumont, Maribel, Sheth, Payal R., DiNunzio, Edward, Rutherford, Stacey A., Ohi, Melanie D., Ermakov, Grigori, Xiao, Li, Secore, Susan, Karczewski, Jerzy, Racine, Fred, Mayhood, Todd, Fischer, Paul, Sher, Xinwei, Gupta, Pulkit, Lacy, D. Borden, Therien, Alex G.
Published in Journal of molecular biology (07.04.2017)
Published in Journal of molecular biology (07.04.2017)
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Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
Quesada-Gómez, Carlos, López-Ureña, Diana, Chumbler, Nicole, Kroh, Heather K, Castro-Peña, Carolina, Rodríguez, César, Orozco-Aguilar, Josué, González-Camacho, Sara, Rucavado, Alexandra, Guzmán-Verri, Caterina, Lawley, Trevor D, Lacy, D Borden, Chaves-Olarte, Esteban
Published in Infection and immunity (01.03.2016)
Published in Infection and immunity (01.03.2016)
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Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin
Tam, John, Icho, Simoun, Utama, Evelyn, Orrell, Kathleen E., Gómez-Biagi, Rodolfo F., Theriot, Casey M., Kroh, Heather K., Rutherford, Stacey A., Lacy, D. Borden, Melnyk, Roman A.
Published in Proceedings of the National Academy of Sciences - PNAS (24.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (24.03.2020)
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Solution Structure of the Cytoplasmic Domain of Erythrocyte Membrane Band 3 Determined by Site-Directed Spin Labeling
Zhou, Zheng, DeSensi, Susan C, Stein, Richard A, Brandon, Suzanne, Dixit, Mrinalini, McArdle, Erin J, Warren, Eric M, Kroh, Heather K, Song, Likai, Cobb, Charles E, Hustedt, Eric J, Beth, Albert H
Published in Biochemistry (Easton) (22.11.2005)
Published in Biochemistry (Easton) (22.11.2005)
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Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants
Gupta, Pulkit, Zhang, Zhifen, Sugiman-Marangos, Seiji N., Tam, John, Raman, Swetha, Julien, Jean-Phillipe, Kroh, Heather K., Lacy, D. Borden, Murgolo, Nicholas, Bekkari, Kavitha, Therien, Alex G., Hernandez, Lorraine D., Melnyk, Roman A.
Published in The Journal of biological chemistry (20.10.2017)
Published in The Journal of biological chemistry (20.10.2017)
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Novel Fluorescent Prothrombin Analogs as Probes of Staphylocoagulase-Prothrombin Interactions
Panizzi, Peter, Friedrich, Rainer, Fuentes-Prior, Pablo, Kroh, Heather K., Briggs, Judy, Tans, Guido, Bode, Wolfram, Bock, Paul E.
Published in The Journal of biological chemistry (13.01.2006)
Published in The Journal of biological chemistry (13.01.2006)
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Murine Intrarectal Instillation of Purified Recombinant Clostridioides difficile Toxins Enables Mechanistic Studies of Pathogenesis
Markham, Nicholas O, Bloch, Sarah C, Shupe, John A, Laubacher, Erin N, Thomas, Audrey K, Kroh, Heather K, Childress, Kevin O, Peritore-Galve, F Christopher, Washington, M Kay, Coffey, Robert J, Lacy, D Borden
Published in Infection and immunity (17.03.2021)
Published in Infection and immunity (17.03.2021)
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A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells
Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Zhang, Zhifen, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Melnyk, Roman A., Spiller, Benjamin W., Lacy, D. Borden
Published in The Journal of biological chemistry (19.01.2018)
Published in The Journal of biological chemistry (19.01.2018)
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Journal Article
Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin
Maddur, Ashoka A., Kroh, Heather K., Aschenbrenner, Mary E., Gibson, Breanne H.Y., Panizzi, Peter, Sheehan, Jonathan H., Meiler, Jens, Bock, Paul E., Verhamme, Ingrid M.
Published in The Journal of biological chemistry (24.04.2020)
Published in The Journal of biological chemistry (24.04.2020)
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Journal Article
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface
Kroh, Heather K., Chandrasekaran, Ramyavardhanee, Rosenthal, Kim, Woods, Rob, Jin, Xiaofang, Ohi, Melanie D., Nyborg, Andrew C., Rainey, G. Jonah, Warrener, Paul, Spiller, Benjamin W., Lacy, D. Borden
Published in The Journal of biological chemistry (01.09.2017)
Published in The Journal of biological chemistry (01.09.2017)
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Skizzle Is a Novel Plasminogen- and Plasmin-binding Protein from Streptococcus agalactiae That Targets Proteins of Human Fibrinolysis to Promote Plasmin Generation
Wiles, Karen G., Panizzi, Peter, Kroh, Heather K., Bock, Paul E.
Published in The Journal of biological chemistry (02.07.2010)
Published in The Journal of biological chemistry (02.07.2010)
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Control of antiviral innate immune response by protein geranylgeranylation
Yang, Shigao, Harding, Alfred T, Sweeney, Catherine, Miao, David, Swan, Gregory, Zhou, Connie, Jiang, Zhaozhao, Fitzgerald, Katherine A, Hammer, Gianna, Bergo, Martin O, Kroh, Heather K, Lacy, D Borden, Sun, Chunxiang, Glogauer, Michael, Que, Loretta G, Heaton, Nicholas S, Wang, Donghai
Published in Science advances (01.05.2019)
Published in Science advances (01.05.2019)
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Active Site-labeled Prothrombin Inhibits Prothrombinase in Vitro and Thrombosis in Vivo
Kroh, Heather K., Panizzi, Peter, Tchaikovski, Svetlana, Baird, T. Regan, Wei, Nancy, Krishnaswamy, Sriram, Tans, Guido, Rosing, Jan, Furie, Bruce, Furie, Barbara C., Bock, Paul E.
Published in The Journal of biological chemistry (01.07.2011)
Published in The Journal of biological chemistry (01.07.2011)
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