Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease
Forner, Stefania, Kawauchi, Shimako, Balderrama-Gutierrez, Gabriela, Kramár, Enikö A., Matheos, Dina P., Phan, Jimmy, Javonillo, Dominic I., Tran, Kristine M., Hingco, Edna, da Cunha, Celia, Rezaie, Narges, Alcantara, Joshua A., Baglietto-Vargas, David, Jansen, Camden, Neumann, Jonathan, Wood, Marcelo A., MacGregor, Grant R., Mortazavi, Ali, Tenner, Andrea J., LaFerla, Frank M., Green, Kim N.
Published in Scientific data (15.10.2021)
Published in Scientific data (15.10.2021)
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Journal Article
Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease
Javonillo, Dominic I, Tran, Kristine M, Phan, Jimmy, Hingco, Edna, Kramár, Enikö A, da Cunha, Celia, Forner, Stefania, Kawauchi, Shimako, Milinkeviciute, Giedre, Gomez-Arboledas, Angela, Neumann, Jonathan, Banh, Crystal E, Huynh, Michelle, Matheos, Dina P, Rezaie, Narges, Alcantara, Joshua A, Mortazavi, Ali, Wood, Marcelo A, Tenner, Andrea J, MacGregor, Grant R, Green, Kim N, LaFerla, Frank M
Published in Frontiers in neuroscience (24.01.2022)
Published in Frontiers in neuroscience (24.01.2022)
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Journal Article
Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer’s risk gene mutation
Johnston, Kevin G., Berackey, Bereket T., Tran, Kristine M., Gelber, Alon, Yu, Zhaoxia, MacGregor, Grant R., Mukamel, Eran A., Tan, Zhiqun, Green, Kim N., Xu, Xiangmin
Published in Molecular psychiatry (05.08.2024)
Published in Molecular psychiatry (05.08.2024)
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Journal Article
BIN1 K358R variant in 5xFAD mice ameliorates AB pathology and microgliosis
Tran, Katelynn, Milinkeviciute, Giedre, Tran, Kristine M, Phan, Jimmy, Da Cunha, Celia, Javonillo, Dominic I, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Genetic diversity promotes resilience in a mouse model of Alzheimer's disease
Soni, Neelakshi, Hohsfield, Lindsay A., Tran, Kristine M., Kawauchi, Shimako, Walker, Amber, Javonillo, Dominic, Phan, Jimmy, Matheos, Dina, Da Cunha, Celia, Uyar, Asli, Milinkeviciute, Giedre, Gomez‐Arboledas, Angela, Tran, Katelynn, Kaczorowski, Catherine C., Wood, Marcelo A., Tenner, Andrea J., LaFerla, Frank M., Carter, Gregory W., Mortazavi, Ali, Swarup, Vivek, MacGregor, Grant R., Green, Kim N.
Published in Alzheimer's & dementia (01.04.2024)
Published in Alzheimer's & dementia (01.04.2024)
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Journal Article
A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
Tran, Kristine M, Kawauchi, Shimako, Kramár, Enikö A, Rezaie, Narges, Liang, Heidi Yahan, Sakr, Jasmine S, Gomez-Arboledas, Angela, Arreola, Miguel A, Cunha, Celia da, Phan, Jimmy, Wang, Shuling, Collins, Sherilyn, Walker, Amber, Shi, Kai-Xuan, Neumann, Jonathan, Filimban, Ghassan, Shi, Zechuan, Milinkeviciute, Giedre, Javonillo, Dominic I, Tran, Katelynn, Gantuz, Magdalena, Forner, Stefania, Swarup, Vivek, Tenner, Andrea J, LaFerla, Frank M, Wood, Marcelo A, Mortazavi, Ali, MacGregor, Grant R, Green, Kim N
Published in Molecular neurodegeneration (17.02.2023)
Published in Molecular neurodegeneration (17.02.2023)
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Journal Article
APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
Tran, Kristine M, Kwang, Nellie, Gomez-Arboledas, Angela, Kawauchi, Shimako, Mar, Cassandra, Chao, Donna, Da Cunha, Celia, Wang, Shuling, Collins, Sherilyn, Walker, Amber, Shi, Kai-Xuan, Alcantara, Joshua A, Neumann, Jonathan, Tenner, Andrea J, LaFerla, Frank M, Hohsfield, Lindsay A, Swarup, Vivek, MacGregor, Grant R, Green, Kim N
Published in bioRxiv (04.06.2024)
Published in bioRxiv (04.06.2024)
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Journal Article
The Clu‐rs2279590_h2kb variant increases axonal and neuritic damage in 5xFAD mice
Milinkeviciute, Giedre, Tran, Katelynn, Tran, Kristine M, Phan, Jimmy, Da Cunha, Celia, Javonillo, Dominic I, Neumann, Jonathan, Alcantara, Joshua A, Walker, Amber, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Trem2 R47H NSS; 5xFAD mice display age/disease progression‐dependent changes in plaques and plaque‐associated microglia, and increased plasma neurofilament light chain
Tran, Kristine M, Kawauchi, Shimako, Javonillo, Dominic I, Da Cunha, Celia, Phan, Jimmy, Rezaie, Narges, Liang, Heidi Yahan, Milinkeviciute, Giedre, Gomez‐Arboledas, Angela, Forner, Stefania, Mortazavi, Ali, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Late‐onset AD risk mutation PICALMH458R prevents plaque generation in 5xFAD mice
Gomez‐Arboledas, Angela, Tran, Kristine M, Javonillo, Dominic I, Phan, Jimmy, Milinkeviciute, Giedre, Da Cunha, Celia, Forner, Stefania, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Late‐onset AD risk mutation PICALM H458R prevents plaque generation in 5xFAD mice
Gomez‐Arboledas, Angela, Tran, Kristine M, Javonillo, Dominic I, Phan, Jimmy, Milinkeviciute, Giedre, Da Cunha, Celia, Forner, Stefania, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2022)
Published in Alzheimer's & dementia (01.12.2022)
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Journal Article
Accumulation of periodic‐acid Schiff granules is increased in the presence of humanized amyloid beta
Forner, Stefania, Javonillo, Dominic I, Tran, Kristine M, Phan, Jimmy, Da Cunha, Celia, Baglietto‐Vargas, David, Kawauchi, Shimako, Tenner, Andrea J, LaFerla, Frank, MacGregor, Grant R, Green, Kim N
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
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Journal Article
Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2 R47H Alzheimer's risk gene mutation
Johnston, Kevin G, Berackey, Bereket T, Tran, Kristine M, Gelber, Alon, Yu, Zhaoxia, MacGregor, Grant R, Mukamel, Eran A, Tan, Zhiqun, Green, Kim N, Xu, Xiangmin
Published in Molecular psychiatry (05.08.2024)
Get full text
Published in Molecular psychiatry (05.08.2024)
Journal Article
A Trem2 R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
Tran, Kristine M, Kawauchi, Shimako, Kramár, Enikö A, Rezaie, Narges, Liang, Heidi Yahan, Sakr, Jasmine S, Gomez-Arboledas, Angela, Arreola, Miguel A, Cunha, Celia da, Phan, Jimmy, Wang, Shuling, Collins, Sherilyn, Walker, Amber, Shi, Kai-Xuan, Neumann, Jonathan, Filimban, Ghassan, Shi, Zechuan, Milinkeviciute, Giedre, Javonillo, Dominic I, Tran, Katelynn, Gantuz, Magdalena, Forner, Stefania, Swarup, Vivek, Tenner, Andrea J, LaFerla, Frank M, Wood, Marcelo A, Mortazavi, Ali, MacGregor, Grant R, Green, Kim N
Published in Molecular neurodegeneration (17.02.2023)
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Published in Molecular neurodegeneration (17.02.2023)
Journal Article
A Trem2 R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine S. Sakr, Angela Gomez-Arboledas, Miguel A. Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Ghassan Filimban, Zechuan Shi, Giedre Milinkeviciute, Dominic I. Javonillo, Katelynn Tran, Magdalena Gantuz, Stefania Forner, Vivek Swarup, Andrea J. Tenner, Frank M. LaFerla, Marcelo A. Wood, Ali Mortazavi, Grant R. MacGregor, Kim N. Green
Published in Molecular neurodegeneration (01.02.2023)
Published in Molecular neurodegeneration (01.02.2023)
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Journal Article
A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques
Tran, Kristine M, Kawauchi, Shimako, Rezaie, Narges, Liang, Heidi Yahan, Arreola, Miguel, Celia Da Cunda, Phan, Jimmy, Collins, Sherilyn, Walker, Amber, Milinkeviciute, Giedre, Neumann, Jonathan, Gomez-Arboledas, Angela, Javonillo, Dominic I, Tran, Katelynn, Gantuz, Magdalena, ner, Stefania, Swarup, Vivek, Tenner, Andrea J, Leferla, Frank, Wood, Marcelo A, Mortazavi, Ali, Macgregor, Grant, Green, Kim N
Published in bioRxiv (12.03.2022)
Published in bioRxiv (12.03.2022)
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Paper
Systematic phenotyping and characterization of the 3xTg-AD mouse model of Alzheimer's Disease
Javonillo, Dominic I, Tran, Kristine M, Phan, Jimmy, Hingco, Edna, Kramár, Enikö A, Da Cunha, Celia, ner, Stefania, Kawauchi, Shimako, Neumann, Jonathan, Banh, Crystal E, Hyunh, Michelle, Matheos, Dina P, Rezai, Narges, Alcantara, Joshua A, Mortazavi, Ali, Wiid, Marcelo A, Tenner, Andrea J, Macgregor, Grant, Green, Kim N, Laferla, Frank M
Published in bioRxiv (02.10.2021)
Published in bioRxiv (02.10.2021)
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Paper