The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome
Krischuns, Tim, Arragain, Benoît, Isel, Catherine, Paisant, Sylvain, Budt, Matthias, Wolff, Thorsten, Cusack, Stephen, Naffakh, Nadia
Published in Nature communications (05.02.2024)
Published in Nature communications (05.02.2024)
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Journal Article
Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase
Arragain, Benoît, Krischuns, Tim, Pelosse, Martin, Drncova, Petra, Blackledge, Martin, Naffakh, Nadia, Cusack, Stephen
Published in Nature communications (19.08.2024)
Published in Nature communications (19.08.2024)
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Journal Article
Dissecting the mechanism of signaling-triggered nuclear export of newly synthesized influenza virus ribonucleoprotein complexes
Schreiber, André, Boff, Laurita, Anhlan, Darisuren, Krischuns, Tim, Brunotte, Linda, Schuberth, Christian, Wedlich-Söldner, Roland, Drexler, Hannes, Ludwig, Stephan
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (14.07.2020)
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Journal Article
Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells
Krischuns, Tim, Günl, Franziska, Henschel, Lea, Binder, Marco, Willemsen, Joschka, Schloer, Sebastian, Rescher, Ursula, Gerlt, Vanessa, Zimmer, Gert, Nordhoff, Carolin, Ludwig, Stephan, Brunotte, Linda
Published in Frontiers in immunology (28.09.2018)
Published in Frontiers in immunology (28.09.2018)
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Journal Article
Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD
Krischuns, Tim, Isel, Catherine, Drncova, Petra, Lukarska, Maria, Pflug, Alexander, Paisant, Sylvain, Navratil, Vincent, Cusack, Stephen, Naffakh, Nadia
Published in PLoS pathogens (23.05.2022)
Published in PLoS pathogens (23.05.2022)
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Journal Article
The ubiquitination landscape of the influenza A virus polymerase
Günl, Franziska, Krischuns, Tim, Schreiber, Julian A., Henschel, Lea, Wahrenburg, Marius, Drexler, Hannes C. A., Leidel, Sebastian A., Cojocaru, Vlad, Seebohm, Guiscard, Mellmann, Alexander, Schwemmle, Martin, Ludwig, Stephan, Brunotte, Linda
Published in Nature communications (11.02.2023)
Published in Nature communications (11.02.2023)
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Journal Article
Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus
Krischuns, Tim, Lukarska, Maria, Naffakh, Nadia, Cusack, Stephen
Published in Annual review of biochemistry (20.06.2021)
Published in Annual review of biochemistry (20.06.2021)
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Journal Article
Correction: Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD
Krischuns, Tim, Isel, Catherine, Drncova, Petra, Lukarska, Maria, Pflug, Alexander, Paisant, Sylvain, Navratil, Vincent, Cusack, Stephen, Naffakh, Nadia
Published in PLoS pathogens (04.01.2023)
Published in PLoS pathogens (04.01.2023)
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Journal Article
The RBPome of influenza A virus NP-mRNA reveals a role for TDP-43 in viral replication
Dupont, Maud, Krischuns, Tim, Gianetto, Quentin Giai, Paisant, Sylvain, Bonazza, Stefano, Brault, Jean-Baptiste, Douché, Thibaut, Arragain, Benoît, Florez-Prada, Alberto, Perez-Perri, Joel I, Hentze, Matthias W, Cusack, Stephen, Matondo, Mariette, Isel, Catherine, Courtney, David G, Naffakh, Nadia
Published in Nucleic acids research (08.07.2024)
Published in Nucleic acids research (08.07.2024)
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Journal Article
Multivalent Dynamic Colocalization of Avian Influenza Polymerase and Nucleoprotein by Intrinsically Disordered ANP32A Reveals the Molecular Basis of Human Adaptation
Camacho-Zarco, Aldo R., Yu, Lefan, Krischuns, Tim, Dedeoglu, Selin, Maurin, Damien, Bouvignies, Guillaume, Crépin, Thibaut, Ruigrok, Rob W. H., Cusack, Stephan, Naffakh, Nadia, Blackledge, Martin
Published in Journal of the American Chemical Society (27.09.2023)
Published in Journal of the American Chemical Society (27.09.2023)
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Journal Article
A community effort in SARS‐CoV‐2 drug discovery
Schimunek, Johannes, Noé, Frank, Olsson, Simon, Raich, Lluís, Winter, Robin, Kurnikova, Maria G., Narangoda, Chamali H., Zubatyuk, Roman, Bosko, Ivan P., Furs, Konstantin V., Karpenko, Anna D., Kornoushenko, Yury V., Shuldau, Mikita, Yushkevich, Artsemi, Benabderrahmane, Mohammed B., Bousquet‐Melou, Patrick, Bureau, Ronan, Charton, Beatrice, Cirou, Bertrand C., Gil, Gérard, Allen, William J., Sirimulla, Suman, Antonopoulos, Nick, Epitropakis, Nikolaos, Krasoulis, Agamemnon, Theodorakis, Stavros, Medvedev, Alexander, Popov, Petr, Zaretckii, Mark, Halmich, Christina, Hochreiter, Sepp, Widrich, Michael, Kumar, Ashutosh, Jain, Moksh J., Korablyov, Maksym, Liu, Cheng‐Hao, Glaab, Enrico, Kaiser, Florian, Schroeder, Michael, Pugliese, Luisa, Athanasiou, Christina, Beccari, Andrea, Carloni, Paolo, Gianquinto, Eleonora, Goßen, Jonas, Joseph, Benjamin P., Kokh, Daria B., Kovachka, Sandra, Manelfi, Candida, Musiani, Francesco, Paiardi, Giulia, Rossetti, Giulia, Spyrakis, Francesca, Tsengenes, Alexandros, Copeland, Conner, Gaiser, Jeremiah, Roy, Amitava, Venkatraman, Vishwesh, Blaschitz, Klara, Cespugli, Marco, Durmaz, Vedat, Fischer, Patrick D., Gorgulla, Christoph, Gruber, Karl, Hetmann, Michael, Kinney, Jamie E., Padmanabha Das, Krishna M., Pandita, Shreya, Singh, Amit, Steinkellner, Georg, Tesseyre, Guilhem, Wagner, Gerhard, Wang, Zi‐Fu, Yust, Ryan J., Druzhilovskiy, Dmitry S., Filimonov, Dmitry A., Pogodin, Pavel V., Poroikov, Vladimir, Rudik, Anastassia V., Stolbov, Leonid A., De Rosa, Maria, De Simone, Giada, Gulotta, Maria R., Perricone, Ugo, Casini, Arturo, Embree, Amanda, Voigt, Christopher A., Chen, Kuang‐Yu, Jacob, Yves, Krischuns, Tim, Lafaye, Pierre, Rodríguez, M. Luis, White, Kris M., Fearon, Daren, Von Delft, Frank, Falsafi, Babak, Ford, Bryan, García‐Sastre, Adolfo, Naffakh, Nadia, Klambauer, Günter
Published in Molecular informatics (01.01.2024)
Published in Molecular informatics (01.01.2024)
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Journal Article
Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors
Hassan, Haitham, Chiavaralli, Jeanne, Hassan, Afnan, Bedda, Loay, Krischuns, Tim, Chen, Kuang-Yu, Li, Alice Shi Ming, Delpal, Adrien, Decroly, Etienne, Vedadi, Masoud, Naffakh, Nadia, Agou, Fabrice, Mallart, Sergio, Arafa, Reem K, Arimondo, Paola B
Published in MedChemComm (22.03.2023)
Published in MedChemComm (22.03.2023)
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Journal Article
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors
Chen, K Y, Krischuns, T, Ortega Varga, L, Harigua-Souiai, E, Paisant, S, Zettor, A, Chiaravalli, J, Courtney, D, O'Brien, A, Baker, S C, Isel, C, Agou, F, Jacob, Y, Blondel, A, Naffakh, N
Published in bioRxiv (21.12.2021)
Published in bioRxiv (21.12.2021)
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Journal Article
Paper
Type B and Type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD
Krischuns, Tim, Isel, Catherine, Drncova, Petra, Lukarska, Maria, Pflug, Alexander, Paisant, Sylvain, Navratil, Vincent, Cusack, Stephen, Naffakh, Nadia
Published in bioRxiv (04.02.2022)
Published in bioRxiv (04.02.2022)
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Paper