SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo
Mainardi, Sara, Mulero-Sánchez, Antonio, Prahallad, Anirudh, Germano, Giovanni, Bosma, Astrid, Krimpenfort, Paul, Lieftink, Cor, Steinberg, Jeffrey D., de Wit, Niels, Gonçalves-Ribeiro, Samuel, Nadal, Ernest, Bardelli, Alberto, Villanueva, Alberto, Bernards, Rene
Published in Nature medicine (01.07.2018)
Published in Nature medicine (01.07.2018)
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Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair
Mylonas, Katie J, O'Sullivan, Eoin D, Humphries, Duncan, Baird, David P, Docherty, Marie-Helena, Neely, Sarah A, Krimpenfort, Paul J, Melk, Anette, Schmitt, Roland, Ferreira-Gonzalez, Sofia, Forbes, Stuart J, Hughes, Jeremy, Ferenbach, David A
Published in Science translational medicine (19.05.2021)
Published in Science translational medicine (19.05.2021)
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Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice
Badhai, Jitendra, Pandey, Gaurav Kumar, Song, Ji-Ying, Krijgsman, Oscar, Bhaskaran, Rajith, Chandrasekaran, Gayathri, Kwon, Min-Chul, Bombardelli, Lorenzo, Monkhorst, Kim, Grasso, Cristoforo, Zevenhoven, John, van der Vliet, Jan, Cozijnsen, Miranda, Krimpenfort, Paul, Peeper, Daniel, van Lohuizen, Maarten, Berns, Anton
Published in The Journal of experimental medicine (01.06.2020)
Published in The Journal of experimental medicine (01.06.2020)
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A doxycycline- and light-inducible Cre recombinase mouse model for optogenetic genome editing
Vizoso, Miguel, E. J. Pritchard, Colin, Bombardelli, Lorenzo, van den Broek, Bram, Krimpenfort, Paul, Beijersbergen, Roderick L., Jalink, Kees, van Rheenen, Jacco
Published in Nature communications (28.10.2022)
Published in Nature communications (28.10.2022)
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Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage
Ferreira-Gonzalez, Sofia, Man, Tak Yung, Esser, Hannah, Aird, Rhona, Kilpatrick, Alastair M, Rodrigo-Torres, Daniel, Younger, Nicholas, Campana, Lara, Gadd, Victoria L, Dwyer, Benjamin, Aleksieva, Niya, Boulter, Luke, Macmillan, Mark T, Wang, Yinmiao, Mylonas, Katie J, Ferenbach, David A, Kendall, Timothy J, Lu, Wei-Yu, Acosta, Juan Carlos, Kurian, Dominic, O'Neill, Stephen, Oniscu, Gabriel C, Banales, Jesus M, Krimpenfort, Paul J, Forbes, Stuart J
Published in Science translational medicine (07.12.2022)
Published in Science translational medicine (07.12.2022)
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Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis
Derksen, Patrick W.B., Liu, Xiaoling, Saridin, Francis, van der Gulden, Hanneke, Zevenhoven, John, Evers, Bastiaan, van Beijnum, Judy R., Griffioen, Arjan W., Vink, Jacqueline, Krimpenfort, Paul, Peterse, Johannes L., Cardiff, Robert D., Berns, Anton, Jonkers, Jos
Published in Cancer cell (01.11.2006)
Published in Cancer cell (01.11.2006)
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Journal Article
A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis
Krimpenfort, Paul, Snoek, Margriet, Lambooij, Jan-Paul, Song, Ji-Ying, van der Weide, Robin, Bhaskaran, Rajith, Teunissen, Hans, Adams, David J., de Wit, Elzo, Berns, Anton
Published in Nature communications (29.03.2019)
Published in Nature communications (29.03.2019)
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DCC Expression by Neurons Regulates Synaptic Plasticity in the Adult Brain
Horn, Katherine E., Glasgow, Stephen D., Gobert, Delphine, Bull, Sarah-Jane, Luk, Tamarah, Girgis, Jacklyn, Tremblay, Marie-Eve, McEachern, Danielle, Bouchard, Jean-François, Haber, Michael, Hamel, Edith, Krimpenfort, Paul, Murai, Keith K., Berns, Anton, Doucet, Guy, Chapman, C. Andrew, Ruthazer, Edward S., Kennedy, Timothy E.
Published in Cell reports (Cambridge) (31.01.2013)
Published in Cell reports (Cambridge) (31.01.2013)
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Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells
Huijbers, Ivo J, Bin Ali, Rahmen, Pritchard, Colin, Cozijnsen, Miranda, Kwon, Min‐Chul, Proost, Natalie, Song, Ji‐Ying, de Vries, Hilda, Badhai, Jitendra, Sutherland, Kate, Krimpenfort, Paul, Michalak, Ewa M, Jonkers, Jos, Berns, Anton
Published in EMBO molecular medicine (01.02.2014)
Published in EMBO molecular medicine (01.02.2014)
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Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice
Derksen, Patrick W B, Braumuller, Tanya M, van der Burg, Eline, Hornsveld, Marten, Mesman, Elly, Wesseling, Jelle, Krimpenfort, Paul, Jonkers, Jos
Published in Disease models & mechanisms (01.05.2011)
Published in Disease models & mechanisms (01.05.2011)
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Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues
Hameyer, Dorothe, Loonstra, Ate, Eshkind, Leonid, Schmitt, Steffen, Antunes, Cecilia, Groen, Annemiek, Bindels, Eric, Jonkers, Jos, Krimpenfort, Paul, Meuwissen, Ralph, Rijswijk, Loes, Bex, Axel, Berns, Anton, Bockamp, Ernesto
Published in Physiological genomics (19.09.2007)
Published in Physiological genomics (19.09.2007)
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Journal Article
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence
Ha, Linan, Ichikawa, Takeshi, Anver, Miriam, Dickins, Ross, Lowe, Scott, Sharpless, Norman E, Krimpenfort, Paul, DePinho, Ronald A, Bennett, Dorothy C, Sviderskaya, Elena V, Merlino, Glenn
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2007)
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Journal Article
Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes
Bull, Sarah-Jane, Bin, Jenea M, Beaumont, Eric, Boutet, Alexandre, Krimpenfort, Paul, Sadikot, Abbas F, Kennedy, Timothy E
Published in The Journal of neuroscience (16.07.2014)
Published in The Journal of neuroscience (16.07.2014)
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Journal Article
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum
Marino, Silvia, Krimpenfort, Paul, Leung, Carly, van der Korput, Hetty A G M, Trapman, Jan, Camenisch, Isabelle, Berns, Anton, Brandner, Sebastian
Published in Development (Cambridge) (01.07.2002)
Published in Development (Cambridge) (01.07.2002)
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Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
Wijnholds, J, Evers, R, van Leusden, M R, Mol, C A, Zaman, G J, Mayer, U, Beijnen, J H, van der Valk, M, Krimpenfort, P, Borst, P
Published in Nature medicine (01.11.1997)
Published in Nature medicine (01.11.1997)
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An inducible mouse model of melanoma expressing a defined tumor antigen
HUIJBERS, Ivo J, KRIMPENFORT, Paul, CHOMEZ, Patrick, VAN DER VALK, Martin A, SONG, Ji-Ying, INDERBERG-SUSO, Else-Marit, SCHMITT-VERHULST, Anne-Marie, BERNS, Anton, VAN DEN EYNDE, Benoit J
Published in Cancer research (Chicago, Ill.) (15.03.2006)
Published in Cancer research (Chicago, Ill.) (15.03.2006)
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cGAS–STING drives ageing-related inflammation and neurodegeneration
Gulen, Muhammet F., Samson, Natasha, Keller, Alexander, Schwabenland, Marius, Liu, Chong, Glück, Selene, Thacker, Vivek V., Favre, Lucie, Mangeat, Bastien, Kroese, Lona J., Krimpenfort, Paul, Prinz, Marco, Ablasser, Andrea
Published in Nature (London) (10.08.2023)
Published in Nature (London) (10.08.2023)
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A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage
Hohenstein, P, Kielman, M F, Breukel, C, Bennett, L M, Wiseman, R, Krimpenfort, P, Cornelisse, C, van Ommen, G J, Devilee, P, Fodde, R
Published in Oncogene (03.05.2001)
Published in Oncogene (03.05.2001)
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