Phase I crossover study of DNA‐protein kinase inhibitor peposertib in healthy volunteers: Effect of food and pharmacokinetics of an oral suspension
Becker, Andreas, Krebs‐Brown, Axel, Vetter, Claudia, Reuter, Tanja, Rodriguez‐Gutierrez, Almudena, You, Xiaoli, Lissy, Michael
Published in Clinical and translational science (01.12.2023)
Published in Clinical and translational science (01.12.2023)
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Asia‐Inclusive Global Development of Enpatoran: Results of an Ethno‐Bridging Study, Intrinsic/Extrinsic Factor Assessments and Disease Trajectory Modeling to Inform Design of a Phase II Multiregional Clinical Trial
Klopp‐Schulze, Lena, Gopalakrishnan, Sathej, Yalkinoglu, Özkan, Kuroki, Yoshihiro, Lu, Hong, Goteti, Kosalaram, Krebs‐Brown, Axel, Nogueira Filho, Marco, Gradhand, Ulrike, Fluck, Markus, Shaw, Jamie, Dong, Jennifer, Venkatakrishnan, Karthik
Published in Clinical pharmacology and therapeutics (01.06.2024)
Published in Clinical pharmacology and therapeutics (01.06.2024)
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Journal Article
The Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat (FG-4592) and Warfarin in Healthy Volunteers: A Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction Study
Groenendaal-van de Meent, Dorien, den Adel, Martin, Rijnders, Sanne, Krebs-Brown, Axel, Kerbusch, Virginie, Golor, Georg, Schaddelee, Marloes
Published in Clinical therapeutics (01.04.2016)
Published in Clinical therapeutics (01.04.2016)
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Journal Article
Effect of Moderate Hepatic Impairment on the Pharmacokinetics and Pharmacodynamics of Roxadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor
Groenendaal-van de Meent, Dorien, Adel, Martin den, Noukens, Jan, Rijnders, Sanne, Krebs-Brown, Axel, Mateva, Lyudmila, Alexiev, Assen, Schaddelee, Marloes
Published in Clinical drug investigation (01.09.2016)
Published in Clinical drug investigation (01.09.2016)
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Journal Article
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial
Nisbet-Brown, Eric, Olivieri, Nancy F, Giardina, Patricia J, Grady, Robert W, Neufeld, Ellis J, Séchaud, Romain, Krebs-Brown, Axel J, Anderson, Judith R, Alberti, Daniele, Sizer, Kurt C, Nathan, David G
Published in The Lancet (British edition) (10.05.2003)
Published in The Lancet (British edition) (10.05.2003)
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Journal Article
Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects
BOLTON, Ann E, BIN PENG, HUBERT, Martine, KREBS-BROWN, Axel, CAPDEVILLE, Renaud, KELLER, Urs, SEIBERLING, Michael
Published in Cancer chemotherapy and pharmacology (01.02.2004)
Published in Cancer chemotherapy and pharmacology (01.02.2004)
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Journal Article
Pharmacokinetics of licarbazepine in healthy volunteers: single and multiple oral doses and effect of food
Souppart, Claire, Gardin, Anne, Greig, Gerard, Balez, Sebastien, Batard, Yannick, Krebs-Brown, Axel, Appel-Dingemanse, Silke
Published in Journal of clinical pharmacology (01.05.2008)
Published in Journal of clinical pharmacology (01.05.2008)
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Journal Article
Comment on: “Why Were More Than 200 Subjects Required to Demonstrate the Bioequivalence of a New Formulation of Levothyroxine with an Old One?”
Krebs-Brown, Axel, Munafo, Alain, Gaikwad, Sumedh, Urgatz, Bogumila, Castello-Bridoux, Claire
Published in Clinical pharmacokinetics (01.02.2020)
Published in Clinical pharmacokinetics (01.02.2020)
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Journal Article
Assessment of the potential of the MET inhibitor tepotinib to affect the pharmacokinetics of CYP3A4 and P-gp substrates
Yalkinoglu, Özkan, Becker, Andreas, Krebs-Brown, Axel, Vetter, Claudia, Lüpfert, Christian, Perrin, Dominique, Heuer, Jürgen, Biedert, Herlind, Hirt, Stefan, Bytyqi, Afrim, Bachmann, Angelika, Strotmann, Rainer
Published in Investigational new drugs (01.08.2023)
Published in Investigational new drugs (01.08.2023)
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Journal Article
The utility of experimental design short courses?
Krebs-Brown, Axel J., Yahyah, Mohammad, Kempson, Robert
Published in Pharmaceutical statistics : the journal of the pharmaceutical industry (01.06.2002)
Published in Pharmaceutical statistics : the journal of the pharmaceutical industry (01.06.2002)
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Journal Article
Comment on "Levothyrox® New and Old Formulations: Are They Switchable for Millions of Patients?"/Reply
Munafo, Alain, Krebs-Brown, Axel, Gaikwad, Sumedh, Urgatz, Bogumila, Castello-Bridoux, Claire, Concordet, Didier, Gandia, Peggy, Montastruc, Jean-Louis, Bousquet-Mélou, Alain, Lees, Peter, Ferran, Aude A, Toutain, Pierre-Louis
Published in Clinical pharmacokinetics (01.07.2019)
Published in Clinical pharmacokinetics (01.07.2019)
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Journal Article
Abstract C162: Assessment of the potential for QTc prolongation by the investigational ATR inhibitor tuvusertib in patients with advanced solid tumors using integrated nonclinical and clinical assessments
Mukker, Jatinder Kaur, Yap, Timothy A., Tolcher, Anthony W., de Bono, Johann S., Plummer, Ruth, Kulkarni, Rohan, Witjes, Han, Diderichsen, Paul Matthias, Krebs-Brown, Axel, Strotmann, Rainer, Szucs, Zoltan, Gounaris, Ioannis, Venkatakrishnan, Karthik
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
FP390MODERATE HEPATIC IMPAIRMENT HAS ONLY A MINOR IMPACT ON THE PHARMACOKINETICS OF ROXADUSTAT, AN ORAL HYPOXIA-INDUCIBLE FACTOR PROLYL-HYDROXYLASE INHIBITOR
Groenendaal−van de Meent, Dorien, den Adel, Martin, Noukens, Jan, Rijnders, Sanne, Krebs-Brown, Axel, Mateva, Lyudmila, Alexiev, Assen, Schaddelee, Marloes
Published in Nephrology, dialysis, transplantation (01.05.2015)
Published in Nephrology, dialysis, transplantation (01.05.2015)
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Evaluation of the CCK-4 model as a challenge paradigm in a population of healthy volunteers within a proof-of-concept study
ESER, Daniela, SCHÜLE, Cornelius, BAGHAI, Thomas, FLOESSER, Anette, KREBS-BROWN, Axel, ENUNWA, Michaela, DE LA MOTTE, Stephan, ENGEL, Rolf, KUCHER, Klaus, RUPPRECHT, Rainer
Published in Psychopharmacologia (01.07.2007)
Published in Psychopharmacologia (01.07.2007)
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Journal Article
Design and Analysis of Cross-Vver Trials (second edition) Jones B, Kenward M (2003) ISBN 0412606402; 408 pages; £52.99; $79.95 CRC Press; http://www.crcpress.co.uk/shopping_cart/products/product_detail.asp?sku=C0640, Cross-Over Trials in Clinical Research (second edition) Senn S (2002) ISBN 0471496537; 364 pages; £55.00; €82.50; $85.00 Wiley; http://www.wileyeurope.com/WileyCDA/WileyTitle/productCd-0471496537.html
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Book Review
Validation of MRI Measurement of Cardiac Output in the Dog: The Effects of Dobutamine and Minoxidil
Hockings, Paul D., Busza, Albert L., Byrne, Joanne, Patel, Bela, Smart, Sean C., Reid, David G., Lloyd, Heather L., White, Alan, Pointing, Karen, Farnfield, Belinda A., Criado-Gonzalez, Ana, Whelan, Greg A., Taylor, Gemma L., Birmingham, Jeffrey M., Slaughter, Mark R., Osborne, Janette A., Krebs-Brown, Axel, Templeton, David
Published in Toxicology mechanisms and methods (01.01.2003)
Published in Toxicology mechanisms and methods (01.01.2003)
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