Safety and Tolerability of ACP-501, a Recombinant Human Lecithin: Cholesterol Acyltransferase, in a Phase 1 Single-Dose Escalation Study
Shamburek, Robert D, Bakker-Arkema, Rebecca, Shamburek, Alexandra M, Freeman, Lita A, Amar, Marcelo J, Auerbach, Bruce, Krause, Brian R, Homan, Reynold, Adelman, Steve J, Collins, Heidi L, Sampson, Maureen, Wolska, Anna, Remaley, Alan T
Published in Circulation research (08.01.2016)
Published in Circulation research (08.01.2016)
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Journal Article
Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement
Shamburek, Robert D., MD, Bakker-Arkema, Rebecca, PharmD, Auerbach, Bruce J., PhD, Krause, Brian R., PhD, Homan, Reynold, PhD, Amar, Marcelo J., MD, Freeman, Lita A., PhD, Remaley, Alan T., MD, PhD
Published in Journal of clinical lipidology (01.03.2016)
Published in Journal of clinical lipidology (01.03.2016)
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Journal Article
Effect of recombinant human lecithin cholesterol acyltransferase infusion on lipoprotein metabolism in mice
Rousset, Xavier, Vaisman, Boris, Auerbach, Bruce, Krause, Brian R, Homan, Reyn, Stonik, John, Csako, Gyorgy, Shamburek, Robert, Remaley, Alan T
Published in The Journal of pharmacology and experimental therapeutics (01.10.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2010)
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Journal Article
The ACAT Inhibitor Avasimibe Reduces Macrophages and Matrix Metalloproteinase Expression in Atherosclerotic Lesions of Hypercholesterolemic Rabbits
Bocan, Thomas M. A, Krause, Brian R, Rosebury, Wendy S, Mueller, Sandra Bak, Lu, Xiaokang, Dagle, Catherine, Major, Terry, Lathia, Chetan, Lee, Helen
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2000)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.01.2000)
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Journal Article
Rapid Change in Plaque Size, Composition, and Molecular Footprint After Recombinant Apolipoprotein A-IMilano (ETC-216) Administration
Ibanez, Borja, MD, Vilahur, Gemma, DVM, PhD, Cimmino, Giovanni, MD, Speidl, Walter S., MD, Pinero, Antonio, MD, Choi, Brian G., MD, Zafar, M. Urooj, MD, Santos-Gallego, Carlos G., MD, Krause, Brian, PhD, Badimon, Lina, PhD, Fuster, Valentin, MD, PhD, FACC, Badimon, Juan J., PhD, FACC
Published in Journal of the American College of Cardiology (01.03.2008)
Published in Journal of the American College of Cardiology (01.03.2008)
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Journal Article
Dose-Related Effects of Repeated ETC-216 (Recombinant Apolipoprotein A-IMilano /1-Palmitoyl-2-Oleoyl Phosphatidylcholine Complexes) Administrations on Rabbit Lipid-Rich Soft Plaques
Parolini, Cinzia, PhD, Marchesi, Marta, PhD, Lorenzon, Paolo, Castano, Mauro, PhD, Balconi, Elena, BS, Miragoli, Luigi, Chaabane, Linda, PhD, Morisetti, Alberto, BS, Lorusso, Vito, BS, Martin, Bradley J., PhD, Bisgaier, Charles L., PhD, Krause, Brian, PhD, Newton, Roger S., PhD, Sirtori, Cesare R., MD, PhD, Chiesa, Giulia, PhD
Published in Journal of the American College of Cardiology (01.03.2008)
Published in Journal of the American College of Cardiology (01.03.2008)
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Journal Article
Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice?
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Journal Article
Identification of an IL-6 response element in the human LCAT promoter
Feister, Hilary A., Auerbach, Bruce J., Cole, Lisa A., Krause, Brian R., Karathanasis, Sotirios K.
Published in Journal of lipid research (01.06.2002)
Published in Journal of lipid research (01.06.2002)
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Journal Article
Influence of Various Central Moieties on the Hypolipidemic Properties of Long Hydrocarbon Chain Diols and Diacids
Oniciu, Daniela C, Dasseux, Jean-Louis H, Yang, Jing, Mueller, Ralf, Pop, Emil, Denysenko, Anna, Duan, Caiming, Huang, Tian-Bao, Zhang, Lianhao, Krause, Brian R, Drake, Sandra L, Lalwani, Narendra, Cramer, Clay T, Goetz, Brian, Pape, Michael E, McKee, Andrew, Fici, Gregory J, Lutostanski, Janell M, Brown, Stephen C, Bisgaier, Charles L
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
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Journal Article
The combined effect of inhibiting both ACAT and HMG-CoA reductase may directly induce atherosclerotic lesion regression
Bocan, Thomas M.A, Krause, Brian R, Rosebury, Wendy S, Lu, Xiaokang, Dagle, Catherine, Bak Mueller, Sandra, Auerbach, Bruce, Sliskovic, D.Robert
Published in Atherosclerosis (01.07.2001)
Published in Atherosclerosis (01.07.2001)
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Journal Article
α-cycloalkyl-substituted ω-keto-dicarboxylic acids as lipid regulating agents
Bell, Roel P.L., Verdijk, Dennis, Relou, Mike, Smith, Dennis, Regeling, Henk, Ebbers, Eelco J., C. Leemhuis, Frank M., Oniciu, Daniela C., Cramer, Clay T., Goetz, Brian, Pape, Michael E., Krause, Brian R., Dasseux, Jean-Louis
Published in Bioorganic & medicinal chemistry (03.01.2005)
Published in Bioorganic & medicinal chemistry (03.01.2005)
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Journal Article
Measurement of Heart Contractility in Isolated Adult Human Primary Cardiomyocytes
Abi Gerges, Najah, Stafford, Alexa, Truong, Ky, Miron, Yannick, Winrow, Bryce, Krause, Brian, Page, Guy, Ghetti, Andre
Published in Journal of visualized experiments (09.08.2022)
Published in Journal of visualized experiments (09.08.2022)
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Journal Article