Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine
Ereño-Orbea, June, Majtan, Tomas, Oyenarte, Iker, Kraus, Jan P, Martínez-Cruz, Luis Alfonso
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
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Journal Article
Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM
Pey, Angel L, Majtan, Tomas, Sanchez-Ruiz, Jose M, Kraus, Jan P
Published in Biochemical journal (01.01.2013)
Published in Biochemical journal (01.01.2013)
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Journal Article
Structural basis of regulation and oligomerization of human cystathionine β-synthase, the central enzyme of transsulfuration
Ereño-Orbea, June, Majtan, Tomas, Oyenarte, Iker, Kraus, Jan P, Martínez-Cruz, Luis Alfonso
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2013)
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Journal Article
Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases
Majtan, Tomas, Pey, Angel L, Fernández, Roberto, Fernández, José A, Martínez-Cruz, Luis A, Kraus, Jan P
Published in PloS one (14.08.2014)
Published in PloS one (14.08.2014)
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Journal Article
Activation of mutant enzyme function in vivo by proteasome inhibitors and treatments that induce Hsp70
Singh, Laishram R, Gupta, Sapna, Honig, Nicholaas H, Kraus, Jan P, Kruger, Warren D
Published in PLoS genetics (01.01.2010)
Published in PLoS genetics (01.01.2010)
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Journal Article
Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
Maclean, Kenneth N., Sikora, Jakub, Kožich, Viktor, Jiang, Hua, Greiner, Lori S., Kraus, Eva, Krijt, Jakub, Crnic, Linda S., Allen, Robert H., Stabler, Sally P., Elleder, Milan, Kraus, Jan P.
Published in Molecular genetics and metabolism (01.10.2010)
Published in Molecular genetics and metabolism (01.10.2010)
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Journal Article
Brain phenotype of transgenic mice overexpressing cystathionine β-synthase
Régnier, Vinciane, Billard, Jean-Marie, Gupta, Sapna, Potier, Brigitte, Woerner, Stéphanie, Paly, Evelyne, Ledru, Aurélie, David, Sabrina, Luilier, Sabrina, Bizot, Jean-Charles, Vacano, Guido, Kraus, Jan P, Patterson, David, Kruger, Warren D, Delabar, Jean M, London, Jaqueline
Published in PloS one (12.01.2012)
Published in PloS one (12.01.2012)
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Journal Article
Import of TAT-Conjugated Propionyl Coenzyme A Carboxylase Using Models of Propionic Acidemia
Collard, Renata, Majtan, Tomas, Park, Insun, Kraus, Jan P.
Published in Molecular and cellular biology (01.03.2018)
Published in Molecular and cellular biology (01.03.2018)
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Journal Article
Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase
Majtan, Tomas, Krijt, Jakub, Sokolová, Jitka, Křížková, Michaela, Ralat, Maria A, Kent, Jana, Gregory, 3rd, Jesse F, Kožich, Viktor, Kraus, Jan P
Published in Antioxidants & redox signaling (01.02.2018)
Published in Antioxidants & redox signaling (01.02.2018)
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Journal Article
Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy
Majtan, Tomas, Park, Insun, Cox, Allaura, Branchford, Brian R, di Paola, Jorge, Bublil, Erez M, Kraus, Jan P
Published in The FASEB journal (01.11.2019)
Published in The FASEB journal (01.11.2019)
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Journal Article
Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria
Majtan, Tomas, Jones, Wendell, Krijt, Jakub, Park, Insun, Kruger, Warren D., Kožich, Viktor, Bassnett, Steven, Bublil, Erez M., Kraus, Jan P.
Published in Molecular therapy (07.03.2018)
Published in Molecular therapy (07.03.2018)
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Journal Article
Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model
Bublil, Erez M, Majtan, Tomas, Park, Insun, Carrillo, Richard S, Hůlková, Helena, Krijt, Jakub, Kožich, Viktor, Kraus, Jan P
Published in The Journal of clinical investigation (01.06.2016)
Published in The Journal of clinical investigation (01.06.2016)
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Journal Article
Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria
Majtan, Tomas, Park, Insun, Carrillo, Richard S, Bublil, Erez M, Kraus, Jan P
Published in Biomacromolecules (12.06.2017)
Published in Biomacromolecules (12.06.2017)
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Journal Article