Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM
Pey, Angel L, Majtan, Tomas, Sanchez-Ruiz, Jose M, Kraus, Jan P
Published in Biochemical journal (01.01.2013)
Published in Biochemical journal (01.01.2013)
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Journal Article
Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine
Ereño-Orbea, June, Majtan, Tomas, Oyenarte, Iker, Kraus, Jan P, Martínez-Cruz, Luis Alfonso
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.09.2014)
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Journal Article
Import of TAT-Conjugated Propionyl Coenzyme A Carboxylase Using Models of Propionic Acidemia
Collard, Renata, Majtan, Tomas, Park, Insun, Kraus, Jan P.
Published in Molecular and cellular biology (01.03.2018)
Published in Molecular and cellular biology (01.03.2018)
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Journal Article
Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases
Majtan, Tomas, Pey, Angel L, Fernández, Roberto, Fernández, José A, Martínez-Cruz, Luis A, Kraus, Jan P
Published in PloS one (14.08.2014)
Published in PloS one (14.08.2014)
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Journal Article
Structural basis of regulation and oligomerization of human cystathionine β-synthase, the central enzyme of transsulfuration
Ereño-Orbea, June, Majtan, Tomas, Oyenarte, Iker, Kraus, Jan P, Martínez-Cruz, Luis Alfonso
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (01.10.2013)
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Journal Article
Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy
Majtan, Tomas, Park, Insun, Cox, Allaura, Branchford, Brian R, di Paola, Jorge, Bublil, Erez M, Kraus, Jan P
Published in The FASEB journal (01.11.2019)
Published in The FASEB journal (01.11.2019)
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Journal Article
Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase
Majtan, Tomas, Krijt, Jakub, Sokolová, Jitka, Křížková, Michaela, Ralat, Maria A, Kent, Jana, Gregory, 3rd, Jesse F, Kožich, Viktor, Kraus, Jan P
Published in Antioxidants & redox signaling (01.02.2018)
Published in Antioxidants & redox signaling (01.02.2018)
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Journal Article
Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria
Majtan, Tomas, Jones, Wendell, Krijt, Jakub, Park, Insun, Kruger, Warren D., Kožich, Viktor, Bassnett, Steven, Bublil, Erez M., Kraus, Jan P.
Published in Molecular therapy (07.03.2018)
Published in Molecular therapy (07.03.2018)
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Journal Article
Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model
Bublil, Erez M, Majtan, Tomas, Park, Insun, Carrillo, Richard S, Hůlková, Helena, Krijt, Jakub, Kožich, Viktor, Kraus, Jan P
Published in The Journal of clinical investigation (01.06.2016)
Published in The Journal of clinical investigation (01.06.2016)
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Journal Article
Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria
Majtan, Tomas, Park, Insun, Carrillo, Richard S, Bublil, Erez M, Kraus, Jan P
Published in Biomacromolecules (12.06.2017)
Published in Biomacromolecules (12.06.2017)
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Journal Article
Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta-synthase for treatment of homocystinuria
Majtan, Tomas, Bublil, Erez M., Park, Insun, Arning, Erland, Bottiglieri, Teodoro, Glavin, Frank, Kraus, Jan P.
Published in Life sciences (1973) (01.05.2018)
Published in Life sciences (1973) (01.05.2018)
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