CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice
Sullivan, Timothy, Miao, Zhenhua, Dairaghi, Daniel J, Krasinski, Antoni, Wang, Yu, Zhao, Bin N, Baumgart, Trageen, Ertl, Linda S, Pennell, Andrew, Seitz, Lisa, Powers, Jay, Zhao, Ruiping, Ungashe, Solomon, Wei, Zheng, Boring, Landin, Tsou, Chia-Lin, Charo, Israel, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C
Published in American journal of physiology. Renal physiology (01.11.2013)
Published in American journal of physiology. Renal physiology (01.11.2013)
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Journal Article
CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS)
Miao, Zhenhua, Ertl, Linda S, Newland, Dale, Zhao, Bin, Wang, Yu, Zang, Xiaoping, Campbell, James J, Liu, Xiaoli, Dang, Ton, Miao, Shichang, Krasinski, Antoni, Punna, Sreenivas, Zeng, Yibin, McMahon, Jeffrey, Zhang, Penglie, Charo, Israel F, Schall, Thomas J, Singh, Rajinder
Published in PloS one (21.03.2018)
Published in PloS one (21.03.2018)
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Journal Article
Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes
Sullivan, Timothy J, Miao, Zhenhua, Zhao, Bin N, Ertl, Linda S, Wang, Yu, Krasinski, Antoni, Walters, Matthew J, Powers, Jay P, Dairaghi, Daniel J, Baumgart, Trageen, Seitz, Lisa C, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C
Published in Metabolism, clinical and experimental (01.11.2013)
Published in Metabolism, clinical and experimental (01.11.2013)
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Journal Article
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
Krasiński, Antoni, Radić, Zoran, Manetsch, Roman, Raushel, Jessica, Taylor, Palmer, Sharpless, K. Barry, Kolb, Hartmuth C.
Published in Journal of the American Chemical Society (11.05.2005)
Published in Journal of the American Chemical Society (11.05.2005)
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Journal Article
Immunosuppressive Myeloid Cells Induced by Chemotherapy Attenuate Antitumor CD4+ T-Cell Responses through the PD-1-PD-L1 Axis
DING, Zhi-Chun, XIAOYUN LU, BLAZAR, Bruce R, MELLOR, Andrew L, MUNN, David H, GANG ZHOU, MIAO YU, LEMOS, Henrique, LEI HUANG, CHANDLER, Phillip, KEBIN LIU, WALTERS, Matthew, KRASINSKI, Antoni, MACK, Matthias
Published in Cancer research (Chicago, Ill.) (01.07.2014)
Published in Cancer research (Chicago, Ill.) (01.07.2014)
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Journal Article
CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood
Zhao, Bin N, Campbell, James J, Salanga, Catherina L, Ertl, Linda S, Wang, Yu, Yau, Simon, Dang, Ton, Zeng, Yibin, McMahon, Jeffrey P, Krasinski, Antoni, Zhang, Penglie, Kufareva, Irina, Handel, Tracy M, Charo, Israel F, Singh, Rajinder, Schall, Thomas J
Published in The Journal of immunology (1950) (15.12.2019)
Published in The Journal of immunology (1950) (15.12.2019)
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Journal Article
5 PROCESSES AND INTERMEDIATES IN THE PREPARATION OF C5aR ANTAGONISTS
PUNNA SREENIVAS, TANAKA HIROKO, FAN PINGCHEN, KALISIAK JAROSLAW, POWERS JAY, ZHANG PENGLIE, KRASINSKI ANTONI, LUI REBECCA
Year of Publication 27.10.2023
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Year of Publication 27.10.2023
Patent
FP240CCR2 INHIBITION IMPROVES RENAL FUNCTION IN MURINE MODELS OF CHRONIC KIDNEY DISEASE
Miao, Zhenhua, Ertl, Linda, Wang, Yu, Zhao, Bin, Zang, Xiaoping, Newland, Dale, Zeng, Yibin, Krasinski, Antoni, Mcmahon, Jeffrey, Liu, Xiaoli, Dang, Ton, Yau, Simon, Campbell, James, Miao, Shichang, Zhang, Penglie, Charo, Israel, Schall, Thomas, Singh, Rajinder
Published in Nephrology, dialysis, transplantation (01.06.2019)
Published in Nephrology, dialysis, transplantation (01.06.2019)
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Journal Article
Abstract 5655: Inhibition of CCR2 potentiates checkpoint inhibitor immunotherapy in murine model of pancreatic cancer
Janson, Christine, Jung, Heiyoun, Ertl, Linda, Liu, Shirley, Dang, Ton, Zeng, Yibin, Krasinski, Antoni, McMahon, Jeff, Zhang, Penglie, Charo, Israel, Singh, Rajinder, Schall, Thomas J.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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보체 성분 C5a 수용체의 유리 염기 결정질 형태
SINGH RAJINDER, LUI REBECCA M, ZHANG PENGLIE, ZENG YIBIN, YAU KWOK, KRASINSKI ANTONI
Year of Publication 11.07.2022
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Year of Publication 11.07.2022
Patent
CCR6 억제제로서의 아릴 설포닐 피페리딘
HARLAND AUBRIE, LUI REBECCA M, ZHANG PENGLIE, YANG JU, ROTH HOWARD S, MARSHALL DANIEL R, LANGE CHRISTOPHER W, KRASINSKI ANTONI
Year of Publication 16.04.2024
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Year of Publication 16.04.2024
Patent
Tu1499 Efficacy of a Small Molecule CCR2 Antagonist in Experimental Model of Chronic Pancreatitis
Xue, Jing, Zhao, Qinglan, Sharma, Vishal, Kalisiak, Jaroslav, Zeng, Yibin, Krasinski, Antoni, Zhang, Penglie, McMahon, Jeff, Campbell, James J, Charo, Israel, Schall, Thomas, Habtezion, Aida
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
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Abstract 1745: Inhibition of chemokine receptor 2 (CCR2) with a small molecule antagonist enhances the effectiveness of checkpoint inhibition by altering the tumor microenvironment in mouse colorectal tumors: Reducing tumor size and increasing long term survival
Campbell, James J., Janson, Christine, Ertl, Linda, Li, Chris, Miao, Zhenhua, Krasinski, Antoni, Lui, Rebecca, Mali, Venkat, McMahon, Jeffrey, Zheng, Yibin, Wang, Yu, Zang, Xiaoping, Chhina, Vicky, Vilalta, Marta, Kumamoto, Alice, Dang, Ton, Liu, Shirley, Yao, Simon, Zhang, Penglie, Schall, Thomas J., Singh, Rajinder
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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FUSED HETEROARYL PYRIDYL AND PHENYL BENZENESUFLONAMIDES AS CCR2 MODULATORS FOR THE TREATMENT OF INFLAMMATION
PUNNA SREENIVAS, UNGASHE SOLOMON, WANG QIANG, ZENG YIBIN, KRASINSKI ANTONI
Year of Publication 12.05.2016
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Year of Publication 12.05.2016
Patent