The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Krasemann, Susanne, Madore, Charlotte, Cialic, Ron, Baufeld, Caroline, Calcagno, Narghes, El Fatimy, Rachid, Beckers, Lien, O’Loughlin, Elaine, Xu, Yang, Fanek, Zain, Greco, David J., Smith, Scott T., Tweet, George, Humulock, Zachary, Zrzavy, Tobias, Conde-Sanroman, Patricia, Gacias, Mar, Weng, Zhiping, Chen, Hao, Tjon, Emily, Mazaheri, Fargol, Hartmann, Kristin, Madi, Asaf, Ulrich, Jason D., Glatzel, Markus, Worthmann, Anna, Heeren, Joerg, Budnik, Bogdan, Lemere, Cynthia, Ikezu, Tsuneya, Heppner, Frank L., Litvak, Vladimir, Holtzman, David M., Lassmann, Hans, Weiner, Howard L., Ochando, Jordi, Haass, Christian, Butovsky, Oleg
Published in Immunity (Cambridge, Mass.) (19.09.2017)
Published in Immunity (Cambridge, Mass.) (19.09.2017)
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Journal Article
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Parhizkar, Samira, Arzberger, Thomas, Brendel, Matthias, Kleinberger, Gernot, Deussing, Maximilian, Focke, Carola, Nuscher, Brigitte, Xiong, Monica, Ghasemigharagoz, Alireza, Katzmarski, Natalie, Krasemann, Susanne, Lichtenthaler, Stefan F., Müller, Stephan A., Colombo, Alessio, Monasor, Laura Sebastian, Tahirovic, Sabina, Herms, Jochen, Willem, Michael, Pettkus, Nadine, Butovsky, Oleg, Bartenstein, Peter, Edbauer, Dieter, Rominger, Axel, Ertürk, Ali, Grathwohl, Stefan A., Neher, Jonas J., Holtzman, David M., Meyer-Luehmann, Melanie, Haass, Christian
Published in Nature neuroscience (01.02.2019)
Published in Nature neuroscience (01.02.2019)
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Journal Article
TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury
Mazaheri, Fargol, Snaidero, Nicolas, Kleinberger, Gernot, Madore, Charlotte, Daria, Anna, Werner, Georg, Krasemann, Susanne, Capell, Anja, Trümbach, Dietrich, Wurst, Wolfgang, Brunner, Bettina, Bultmann, Sebastian, Tahirovic, Sabina, Kerschensteiner, Martin, Misgeld, Thomas, Butovsky, Oleg, Haass, Christian
Published in EMBO reports (01.07.2017)
Published in EMBO reports (01.07.2017)
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Journal Article
Exosomes and the Prion Protein: More than One Truth
Hartmann, Alexander, Muth, Christiane, Dabrowski, Oliver, Krasemann, Susanne, Glatzel, Markus
Published in Frontiers in neuroscience (19.04.2017)
Published in Frontiers in neuroscience (19.04.2017)
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Journal Article
Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres
Abreu, Celina Monteiro, Gama, Lucio, Krasemann, Susanne, Chesnut, Megan, Odwin-Dacosta, Shelly, Hogberg, Helena T, Hartung, Thomas, Pamies, David
Published in Frontiers in microbiology (04.12.2018)
Published in Frontiers in microbiology (04.12.2018)
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Journal Article
Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta‐mediated neurotoxicity
Falker, Clemens, Hartmann, Alexander, Guett, Inga, Dohler, Frank, Altmeppen, Hermann, Betzel, Christian, Schubert, Robin, Thurm, Dana, Wegwitz, Florian, Joshi, Pooja, Verderio, Claudia, Krasemann, Susanne, Glatzel, Markus
Published in Journal of neurochemistry (01.04.2016)
Published in Journal of neurochemistry (01.04.2016)
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Journal Article
Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice
Butovsky, Oleg, Jedrychowski, Mark P., Cialic, Ron, Krasemann, Susanne, Murugaiyan, Gopal, Fanek, Zain, Greco, David J., Wu, Pauline M., Doykan, Camille E., Kiner, Olga, Lawson, Robert J., Frosch, Matthew P., Pochet, Nathalie, Fatimy, Rachid El, Krichevsky, Anna M., Gygi, Steven P., Lassmann, Hans, Berry, James, Cudkowicz, Merit E., Weiner, Howard L.
Published in Annals of neurology (01.01.2015)
Published in Annals of neurology (01.01.2015)
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Journal Article
Lassa virus persistence with high viral titers following experimental infection in its natural reservoir host, Mastomys natalensis
Hoffmann, Chris, Krasemann, Susanne, Wurr, Stephanie, Hartmann, Kristin, Adam, Elisa, Bockholt, Sabrina, Müller, Jonas, Günther, Stephan, Oestereich, Lisa
Published in Nature communications (29.10.2024)
Published in Nature communications (29.10.2024)
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Journal Article
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
Krasemann, Susanne, Haferkamp, Undine, Pfefferle, Susanne, Woo, Marcel S., Heinrich, Fabian, Schweizer, Michaela, Appelt-Menzel, Antje, Cubukova, Alevtina, Barenberg, Janica, Leu, Jennifer, Hartmann, Kristin, Thies, Edda, Littau, Jessica Lisa, Sepulveda-Falla, Diego, Zhang, Liang, Ton, Kathy, Liang, Yan, Matschke, Jakob, Ricklefs, Franz, Sauvigny, Thomas, Sperhake, Jan, Fitzek, Antonia, Gerhartl, Anna, Brachner, Andreas, Geiger, Nina, König, Eva-Maria, Bodem, Jochen, Franzenburg, Sören, Franke, Andre, Moese, Stefan, Müller, Franz-Josef, Geisslinger, Gerd, Claussen, Carsten, Kannt, Aimo, Zaliani, Andrea, Gribbon, Philip, Ondruschka, Benjamin, Neuhaus, Winfried, Friese, Manuel A., Glatzel, Markus, Pless, Ole
Published in Stem cell reports (08.02.2022)
Published in Stem cell reports (08.02.2022)
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Journal Article
Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans
Zickler, Martin, Stanelle-Bertram, Stephanie, Ehret, Sandra, Heinrich, Fabian, Lange, Philine, Schaumburg, Berfin, Kouassi, Nancy Mounogou, Beck, Sebastian, Jaeckstein, Michelle Y., Mann, Oliver, Krasemann, Susanne, Schroeder, Maria, Jarczak, Dominik, Nierhaus, Axel, Kluge, Stefan, Peschka, Manuela, Schlüter, Hartmut, Renné, Thomas, Pueschel, Klaus, Kloetgen, Andreas, Scheja, Ludger, Ondruschka, Benjamin, Heeren, Joerg, Gabriel, Guelsah
Published in Cell metabolism (04.01.2022)
Published in Cell metabolism (04.01.2022)
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Journal Article
Four-wheel-drive immune protection
Heinrich, Fabian, Krasemann, Susanne
Published in Signal transduction and targeted therapy (27.09.2022)
Published in Signal transduction and targeted therapy (27.09.2022)
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Journal Article
Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever
Oestereich, Lisa, Rieger, Toni, Neumann, Melanie, Bernreuther, Christian, Lehmann, Maria, Krasemann, Susanne, Wurr, Stephanie, Emmerich, Petra, de Lamballerie, Xavier, Ölschläger, Stephan, Günther, Stephan
Published in PLoS neglected tropical diseases (01.05.2014)
Published in PLoS neglected tropical diseases (01.05.2014)
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Journal Article
YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias
Llorens, Franc, Thüne, Katrin, Tahir, Waqas, Kanata, Eirini, Diaz-Lucena, Daniela, Xanthopoulos, Konstantinos, Kovatsi, Eleni, Pleschka, Catharina, Garcia-Esparcia, Paula, Schmitz, Matthias, Ozbay, Duru, Correia, Susana, Correia, Ângela, Milosevic, Ira, Andréoletti, Olivier, Fernández-Borges, Natalia, Vorberg, Ina M, Glatzel, Markus, Sklaviadis, Theodoros, Torres, Juan Maria, Krasemann, Susanne, Sánchez-Valle, Raquel, Ferrer, Isidro, Zerr, Inga
Published in Molecular neurodegeneration (10.11.2017)
Published in Molecular neurodegeneration (10.11.2017)
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Journal Article
Complement 3 + -astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
Hartmann, Kristin, Sepulveda-Falla, Diego, Rose, Indigo V L, Madore, Charlotte, Muth, Christiane, Matschke, Jakob, Butovsky, Oleg, Liddelow, Shane, Glatzel, Markus, Krasemann, Susanne
Published in Acta neuropathologica communications (22.05.2019)
Published in Acta neuropathologica communications (22.05.2019)
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Journal Article
New Postmortem Perspective on Emerging SARS-CoV-2 Variants of Concern, Germany
Heinrich, Fabian, Huter, Tobias, Mertens, Sophie, Lange, Philine, Vering, Jessica, Heinemann, Axel, Nörz, Dominik Sebastian, Hoffmann, Armin, Aepfelbacher, Martin, Ondruschka, Benjamin, Krasemann, Susanne, Lütgehetmann, Marc
Published in Emerging infectious diseases (01.03.2023)
Published in Emerging infectious diseases (01.03.2023)
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Journal Article
Reactive Astrocytes Contribute to Alzheimer's Disease-Related Neurotoxicity and Synaptotoxicity in a Neuron-Astrocyte Co-culture Assay
Wasilewski, David, Villalba-Moreno, Nelson David, Stange, Inke, Glatzel, Markus, Sepulveda-Falla, Diego, Krasemann, Susanne
Published in Frontiers in cellular neuroscience (21.01.2022)
Published in Frontiers in cellular neuroscience (21.01.2022)
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Journal Article
Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy
Tallarek, Ann-Christin, Urbschat, Christopher, Fonseca Brito, Luis, Stanelle-Bertram, Stephanie, Krasemann, Susanne, Frascaroli, Giada, Thiele, Kristin, Wieczorek, Agnes, Felber, Nadine, Lütgehetmann, Marc, Markert, Udo R., Hecher, Kurt, Brune, Wolfram, Stahl, Felix, Gabriel, Gülsah, Diemert, Anke, Arck, Petra Clara
Published in Frontiers in immunology (03.06.2021)
Published in Frontiers in immunology (03.06.2021)
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Journal Article
Chimeric Mice with Competent Hematopoietic Immunity Reproduce Key Features of Severe Lassa Fever
Oestereich, Lisa, Lüdtke, Anja, Ruibal, Paula, Pallasch, Elisa, Kerber, Romy, Rieger, Toni, Wurr, Stephanie, Bockholt, Sabrina, Pérez-Girón, José V, Krasemann, Susanne, Günther, Stephan, Muñoz-Fontela, César
Published in PLoS pathogens (01.05.2016)
Published in PLoS pathogens (01.05.2016)
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Journal Article
Young COVID-19 Patients Show a Higher Degree of Microglial Activation When Compared to Controls
Matschke, Jakob, Lahann, Henri, Krasemann, Susanne, Altmeppen, Hermann, Pfefferle, Susanne, Galliciotti, Giovanna, Fitzek, Antonia, Sperhake, Jan-Peter, Ondruschka, Benjamin, Busch, Miriam, Rotermund, Natalie, Schulz, Kristina, Lohr, Christian, Dottermusch, Matthias, Glatzel, Markus
Published in Frontiers in neurology (16.06.2022)
Published in Frontiers in neurology (16.06.2022)
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