Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
Paris, Jasmin, Morgan, Marcos, Campos, Joana, Spencer, Gary J., Shmakova, Alena, Ivanova, Ivayla, Mapperley, Christopher, Lawson, Hannah, Wotherspoon, David A., Sepulveda, Catarina, Vukovic, Milica, Allen, Lewis, Sarapuu, Annika, Tavosanis, Andrea, Guitart, Amelie V., Villacreces, Arnaud, Much, Christian, Choe, Junho, Azar, Ali, van de Lagemaat, Louie N., Vernimmen, Douglas, Nehme, Ali, Mazurier, Frederic, Somervaille, Tim C.P., Gregory, Richard I., O’Carroll, Dónal, Kranc, Kamil R.
Published in Cell stem cell (03.07.2019)
Published in Cell stem cell (03.07.2019)
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The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
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Published in The Journal of experimental medicine (14.03.2011)
Published in The Journal of experimental medicine (14.03.2011)
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MYC sensitises cells to apoptosis by driving energetic demand
Edwards-Hicks, Joy, Su, Huizhong, Mangolini, Maurizio, Yoneten, Kubra K, Wills, Jimi, Rodriguez-Blanco, Giovanny, Young, Christine, Cho, Kevin, Barker, Heather, Muir, Morwenna, Guerrieri, Ania Naila, Li, Xue-Feng, White, Rachel, Manasterski, Piotr, Mandrou, Elena, Wills, Karen, Chen, Jingyu, Abraham, Emily, Sateri, Kianoosh, Qian, Bin-Zhi, Bankhead, Peter, Arends, Mark, Gammoh, Noor, von Kriegsheim, Alex, Patti, Gary J, Sims, Andrew H, Acosta, Juan Carlos, Brunton, Valerie, Kranc, Kamil R, Christophorou, Maria, Pearce, Erika L, Ringshausen, Ingo, Finch, Andrew J
Published in Nature communications (09.08.2022)
Published in Nature communications (09.08.2022)
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hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival
Pellicano, Francesca, Park, Laura, Hopcroft, Lisa E.M., Shah, Mansi M., Jackson, Lorna, Scott, Mary T., Clarke, Cassie J., Sinclair, Amy, Abraham, Sheela A., Hair, Alan, Helgason, G. Vignir, Aspinall-O'Dea, Mark, Bhatia, Ravi, Leone, Gustavo, Kranc, Kamil R., Whetton, Anthony D., Holyoake, Tessa L.
Published in Blood (05.04.2018)
Published in Blood (05.04.2018)
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Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death
Woodley, Keith, Dillingh, Laura S, Giotopoulos, George, Madrigal, Pedro, Rattigan, Kevin M, Philippe, Céline, Dembitz, Vilma, Magee, Aoife M S, Asby, Ryan, van de Lagemaat, Louie N, Mapperley, Christopher, James, Sophie C, Prehn, Jochen H M, Tzelepis, Konstantinos, Rouault-Pierre, Kevin, Vassiliou, George S, Kranc, Kamil R, Helgason, G Vignir, Huntly, Brian J P, Gallipoli, Paolo
Published in Nature communications (14.04.2023)
Published in Nature communications (14.04.2023)
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Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia
Menendez-Gonzalez, Juan Bautista, Vukovic, Milica, Abdelfattah, Ali, Saleh, Lubaid, Almotiri, Alhomidi, Thomas, Leigh-anne, Agirre-Lizaso, Aloña, Azevedo, Aleksandra, Menezes, Ana Catarina, Tornillo, Giusy, Edkins, Sarah, Kong, Kay, Giles, Peter, Anjos-Afonso, Fernando, Tonks, Alex, Boyd, Ashleigh S., Kranc, Kamil R., Rodrigues, Neil P.
Published in Stem cell reports (13.08.2019)
Published in Stem cell reports (13.08.2019)
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A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells
Turner, David J, Saveliev, Alexander, Salerno, Fiamma, Matheson, Louise S, Screen, Michael, Lawson, Hannah, Wotherspoon, David, Kranc, Kamil R, Turner, Martin
Published in eLife (22.04.2022)
Published in eLife (22.04.2022)
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Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny
Calaminus, Simon D J, Guitart, Amelie V, Guitart, Amelie, Sinclair, Amy, Schachtner, Hannah, Watson, Steve P, Holyoake, Tessa L, Kranc, Kamil R, Machesky, Laura M
Published in PloS one (27.12.2012)
Published in PloS one (27.12.2012)
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Immunodeficient NBSGW mouse strain allows chemotherapy modeling in AML patient‐derived xenografts
Dembitz, Vilma, Durko, Jozef, Campos, Joana, James, Sophie C., Lawson, Hannah, Kranc, Kamil R., Gallipoli, Paolo
Published in HemaSphere (01.01.2024)
Published in HemaSphere (01.01.2024)
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Intrinsic function of the peptidylarginine deiminase PADI4 is dispensable for normal haematopoiesis
Young, Christine, Russell, John R, Van De Lagemaat, Louie N, Lawson, Hannah, Mapperley, Christopher, Kranc, Kamil R, Christophorou, Maria A
Published in Biology open (15.06.2022)
Published in Biology open (15.06.2022)
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CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands
van de Lagemaat, Louie N, Flenley, Maria, Lynch, Magnus D, Garrick, David, Tomlinson, Simon R, Kranc, Kamil R, Vernimmen, Douglas
Published in Epigenetics & chromatin (06.10.2018)
Published in Epigenetics & chromatin (06.10.2018)
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Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self‐Renewal of Mouse Embryonic Stem Cells
Kranc, Kamil R., Oliveira, Daniel V., Armesilla-Diaz, Alejandro, Pacheco-Leyva, Ivette, Catarina Matias, Ana, Luisa Escapa, Ana, Subramani, Chithra, Wheadon, Helen, Trindade, Marlene, Nichols, Jennifer, Kaji, Keisuke, Enver, Tariq, Bragança, José
Published in Stem cells (Dayton, Ohio) (01.03.2015)
Published in Stem cells (Dayton, Ohio) (01.03.2015)
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NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells
Codino, Azzurra, Turowski, Tomasz, van de Lagemaat, Louie N., Ivanova, Ivayla, Tavosanis, Andrea, Much, Christian, Auchynnikava, Tania, Vasiliauskaitė, Lina, Morgan, Marcos, Rappsilber, Juri, Allshire, Robin C., Kranc, Kamil R., Tollervey, David, O'Carroll, Dónal
Published in iScience (23.07.2021)
Published in iScience (23.07.2021)
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The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function
Mapperley, Christopher, van de Lagemaat, Louie N, Lawson, Hannah, Tavosanis, Andrea, Paris, Jasmin, Campos, Joana, Wotherspoon, David, Durko, Jozef, Sarapuu, Annika, Choe, Junho, Ivanova, Ivayla, Krause, Daniela S, von Kriegsheim, Alex, Much, Christian, Morgan, Marcos, Gregory, Richard I, Mead, Adam J, O'Carroll, Dónal, Kranc, Kamil R
Published in The Journal of experimental medicine (01.03.2021)
Published in The Journal of experimental medicine (01.03.2021)
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Transcriptional Coactivator Cited2 Induces Bmi1 and Mel18 and Controls Fibroblast Proliferation via Ink4a/ARF
Kranc, Kamil R., Bamforth, Simon D., Bragança, José, Norbury, Chris, van Lohuizen, Maarten, Bhattacharya, Shoumo
Published in Molecular and Cellular Biology (01.11.2003)
Published in Molecular and Cellular Biology (01.11.2003)
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