A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade
Geuijen, Cecile, Tacken, Paul, Wang, Liang-Chuan, Klooster, Rinse, van Loo, Pieter Fokko, Zhou, Jing, Mondal, Arpita, Liu, Yao-Bin, Kramer, Arjen, Condamine, Thomas, Volgina, Alla, Hendriks, Linda J A, van der Maaden, Hans, Rovers, Eric, Engels, Steef, Fransen, Floris, den Blanken-Smit, Renate, Zondag-van der Zande, Vanessa, Basmeleh, Abdul, Bartelink, Willem, Kulkarni, Ashwini, Marissen, Wilfred, Huang, Cheng-Yen, Hall, Leslie, Harvey, Shane, Kim, Soyeon, Martinez, Marina, O'Brien, Shaun, Moon, Edmund, Albelda, Steven, Kanellopoulou, Chrysi, Stewart, Shaun, Nastri, Horacio, Bakker, Alexander B H, Scherle, Peggy, Logtenberg, Ton, Hollis, Gregory, de Kruif, John, Huber, Reid, Mayes, Patrick A, Throsby, Mark
Published in Nature communications (21.07.2021)
Published in Nature communications (21.07.2021)
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Isolation and Characterization of Human Monoclonal Antibodies from Individuals Infected with West Nile Virus
THROSBY, Mark, GEUIJEN, Cecile, SMIT, Renate, VISSER, Therese J, BIJL, Nora, MARISSEN, Wilfred E, LOEB, Mark, KELVIN, David J, PREISER, Wolfgang, TER MEULEN, Jan, DE KRUIF, John, GOUDSMIT, Jaap, BAKKER, Arjen Q, KORIMBOCUS, Jehanara, ARJEN KRAMER, R, CLIJSTERS-VAN DER HORST, Marieke, DE JONG, Maureen, JONGENEELEN, Mandy, THIJSSE, Sandra
Published in Journal of Virology (01.07.2006)
Published in Journal of Virology (01.07.2006)
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Novel Human Monoclonal Antibody Combination Effectively Neutralizing Natural Rabies Virus Variants and Individual In Vitro Escape Mutants
BAKKER, Alexander B. H, MARISSEN, Wilfred E, DIETZSCHOLD, Bernhard, RUPPRECHT, Charles E, GOUDSMIT, Jaap, KRAMER, R. Arjen, RICE, Amy B, WELDON, William C, NIEZGODA, Michael, HANLON, Cathleen A, THIJSSE, Sandra, BACKUS, Harold H. J, DE KRUIF, John
Published in Journal of Virology (01.07.2005)
Published in Journal of Virology (01.07.2005)
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A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis
de Kruif, John, Bakker, Alexander B H, Marissen, Wilfred E, Kramer, R Arjen, Throsby, Mark, Rupprecht, Charles E, Goudsmit, Jaap
Published in Annual review of medicine (01.01.2007)
Published in Annual review of medicine (01.01.2007)
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820 MCLA-145 is a bispecific IgG1 antibody that inhibits PD-1/PD-L1 signaling while simultaneously activating CD137 signaling on T cells
Tacken, Paul, Wang, Liang-chuan, Klooster, Rinse, Loo, Pieter Fokko Van, Zhou, Jing, Mondal, Arpita, Liu, Yao-Bin, Kramer, Arjen, Condamine, Thomas, Volgina, Alla, Hendriks, Linda, Maaden, Hans van der, Rovers, Eric, Engels, Steef, Fransen, Floris, Blanken-Smit, Renate den, Zande, Vanessa Zondag-van der, Basmeleh, Abdul, Bartelink, Willem, Kulkarni, Ashwini, Marissen, Wilfred, Huang, Cheng-Yen, Hall, Leslie, Harvey, Shane, Kanellopoulou, Chrysi, Stewart, Shaun, Nastri, Horacio, Bakker, Lex, Logtenberg, Ton, Plyte, Simon, Mayes, Patrick, Throsby, Mark, Geuijen, Cecile
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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The human antibody repertoire specific for rabies virus glycoprotein as selected from immune libraries
Kramer, R. Arjen, Marissen, Wilfred E., Goudsmit, Jaap, Visser, Therese J., Clijsters‐Van der Horst, Marieke, Bakker, Arjen Q., de Jong, Maureen, Jongeneelen, Mandy, Thijsse, Sandra, Backus, Harold H. J., Rice, Amy B., Weldon, William C., Rupprecht, Charles E., Dietzschold, Bernhard, Bakker, Alexander B. H., de Kruif, John
Published in European journal of immunology (01.07.2005)
Published in European journal of immunology (01.07.2005)
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Abstract 957: Zenocutuzumab: An antibody that can overcome HER3 mediated HRG signalling in tumor cells by docking on HER2
Geuijen, Cecile, Maussang-Detaille, David, Gallenne, Tristan, Hendriks, Linda, Kramer, Arjen, Gerlach, Jan, Throsby, Mark, de Kruif, John
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT
Kramer, R. Arjen, Brandenburg, Klaus, Vandeputte‐Rutten, Lucy, Werkhoven, Marjolein, Gros, Piet, Dekker, Niek, Egmond, Maarten R.
Published in European journal of biochemistry (01.03.2002)
Published in European journal of biochemistry (01.03.2002)
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Abstract 4999: Preclinical evaluation of MCLA-129, a bispecific antibody targeting EGFR and c-MET on solid tumor cells, in comparison with amivantamab
de Gorter, David J.J., Deshiere, Alexandre, Kramer, Arjen, van Rosmalen, Martijn, Mortensen, Franziska, Geuijen, Cecile
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis
van Loo, Pieter Fokko, Hangalapura, Basav N., Thordardottir, Soley, Gibbins, John D., Veninga, Henrike, Hendriks, Linda J. A., Kramer, Arjen, Roovers, Rob C., Leenders, Marij, de Kruif, John, Doornbos, Robert P., Sirulnik, Andres, Throsby, Mark, Logtenberg, Ton, Dolstra, Harry, Bakker, Alexander B. H.
Published in Expert opinion on biological therapy (03.07.2019)
Published in Expert opinion on biological therapy (03.07.2019)
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Novel Rabies Virus-Neutralizing Epitope Recognized by Human Monoclonal Antibody: Fine Mapping and Escape Mutant Analysis
MARISSEN, Wilfred E, ARJEN KRAMER, R, JONGENEELEN, Mandy, THIJSSE, Sandra, THROSBY, Mark, DE KRUIF, John, RUPPRECHT, Charles E, DIETZSCHOLD, Bernhard, GOUDSMIT, Jaap, BAKKER, Alexander B. H, RICE, Amy, WELDON, William C, NIEZGODA, Michael, FABER, Milosz, SLOOTSTRA, Jerry W, MELOEN, Rob H, CLIJSTERS-VAN DER HORST, Marieke, VISSER, Therese J
Published in Journal of Virology (01.04.2005)
Published in Journal of Virology (01.04.2005)
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Abstract 541: An unbiased screen identifies a CD137xPD-L1 bispecific IgG1 antibody with unique T cell activation and binding properties
Geuijen, Cecile A., Tacken, Paul, Klooster, Rinse, Nastri, Horacio, Stewart, Shaun, Zhou, Jing, Wang, Steve, Huang, Cheng-Yen, Kramer, Arjen, Kaldenberg-Hendriks, Linda, Kruif, John de, Blanken-Smit, Renate den, Zande, Vanessa Zondag-van de, Basmeleh, Abdul, Bartelink, Willem, Mayes, Patrick, Hollis, Gregory, Huber, Reid, Throsby, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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A novel helper phage that improves phage display selection efficiency by preventing the amplification of phages without recombinant protein
Kramer, R. Arjen, Cox, Freek, van der Horst, Marieke, van den Oudenrijn, Sonja, Res, Pieter C. M., Bia, Judith, Logtenberg, Ton, de Kruif, John
Published in Nucleic acids research (01.06.2003)
Published in Nucleic acids research (01.06.2003)
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Generation of stable cell clones expressing mixtures of human antibodies
de Kruif, John, Kramer, Arjen, Nijhuis, Roy, van der Zande, Vanessa, den Blanken, Renate, Clements, Carina, Visser, Therèse, Keehnen, Rob, den Hartog, Marcel, Throsby, Mark, Logtenberg, Ton
Published in Biotechnology and bioengineering (01.08.2010)
Published in Biotechnology and bioengineering (01.08.2010)
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Abstract LB-261: Mechanism of action of MCLA-128, a humanized bispecific IgG1 antibody targeting the HER2:HER3 heterodimer
Geuijen, Cecile, Rovers, Eric, Gallenne, Tristan, Maussang-Detaille, David, Kramer, Arjen, Nieuwenhuizen, Nellie, Clements, Carina, van Zoest, Katinka, Nijhuis, Roy, Visser, Therese, Den Blanken-Smit, Renate, Bartelink, Willem, Zondag-van der Zande, Vanessa, Kaldenberg, Linda, van Loo, Pieter-Fokko, Roovers, Rob, Doornbos, Robert, Price, Leo, Braam, Stefan, van Driel, Setareh, Bakker, Lex, Logtenberg, Ton, de Kruif, John, Throsby, Mark
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Human Immunoglobulin Repertoires against Tetanus Toxoid Contain a Large and Diverse Fraction of High-Affinity Promiscuous VH Genes
de Kruif, John, Kramer, Arjen, Visser, Therèse, Clements, Carina, Nijhuis, Roy, Cox, Freek, van der Zande, Vanessa, Smit, Renate, Pinto, Daniel, Throsby, Mark, Logtenberg, Ton
Published in Journal of molecular biology (03.04.2009)
Published in Journal of molecular biology (03.04.2009)
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Preclinical activity of MCLA-128, an ADCC enhanced bispecific IgG1 antibody targeting the HER2:HER3 heterodimer
Geuijen, Cecile, Rovers, Eric, Nijhuis, Roy, den Blanken-Smit, Renate, Visser, Therese, Bartelink, Willem, Kramer, Arjen, Zondag-van der Zande, Vanessa, Clements, Carina, Kaldenberg, Linda, Nieuwenhuizen, Nellie, van Loo, Pieter Fokko, Roovers, Rob, Gallenne, Tristan, Price, Leo, Van Driel Shamsili, Setareh, Bakker, Lex, Logtenberg, Ton, de Kruif, John, Throsby, Mark
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Human Immunoglobulin Repertoires against Tetanus Toxoid Contain a Large and Diverse Fraction of High-Affinity Promiscuous V H Genes
de Kruif, John, Kramer, Arjen, Visser, Therèse, Clements, Carina, Nijhuis, Roy, Cox, Freek, van der Zande, Vanessa, Smit, Renate, Pinto, Daniel, Throsby, Mark, Logtenberg, Ton
Published in Journal of molecular biology (03.04.2009)
Published in Journal of molecular biology (03.04.2009)
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