The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats
Witkin, J M, Cerne, R, Davis, P G, Freeman, K B, do Carmo, J M, Rowlett, J K, Methuku, K R, Okun, A, Gleason, S D, Li, X, Krambis, M J, Poe, M, Li, G, Schkeryantz, J M, Jahan, R, Yang, L, Guo, W, Golani, L K, Anderson, W H, Catlow, J T, Jones, T M, Porreca, F, Smith, J L, Knopp, K L, Cook, J M
Published in Pharmacology, biochemistry and behavior (01.05.2019)
Published in Pharmacology, biochemistry and behavior (01.05.2019)
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Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA A receptors: Improved bioavailability enhances anticonvulsant efficacy
Witkin, J M, Smith, J L, Ping, X, Gleason, S D, Poe, M M, Li, G, Jin, X, Hobbs, J, Schkeryantz, J M, McDermott, J S, Alatorre, A I, Siemian, J N, Cramer, J W, Airey, D C, Methuku, K R, Tiruveedhula, V V N P B, Jones, T M, Crawford, J, Krambis, M J, Fisher, J L, Cook, J M, Cerne, R
Published in Neuropharmacology (15.07.2018)
Published in Neuropharmacology (15.07.2018)
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Journal Article
The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats
Witkin, J.M., Cerne, R., Davis, P.G., Freeman, K.B., do Carmo, J.M., Rowlett, J.K., Methuku, K.R., Okun, A., Gleason, S.D., Li, X., Krambis, M.J., Poe, M., Li, G., Schkeryantz, J.M., Jahan, R., Yang, L., Guo, W., Golani, L.K., Anderson, W.H., Catlow, J.T., Jones, T.M., Porreca, F., Smith, J.L., Knopp, K.L., Cook, J.M.
Published in Pharmacology, biochemistry and behavior (01.05.2019)
Published in Pharmacology, biochemistry and behavior (01.05.2019)
Get full text
Journal Article
Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy
Witkin, J.M., Smith, J.L., Ping, X., Gleason, S.D., Poe, M.M., Li, G., Jin, X., Hobbs, J., Schkeryantz, J.M., McDermott, J.S., Alatorre, A.I., Siemian, J.N., Cramer, J.W., Airey, D.C., Methuku, K.R., Tiruveedhula, V.V.N.P.B., Jones, T.M., Crawford, J., Krambis, M.J., Fisher, J.L., Cook, J.M., Cerne, R.
Published in Neuropharmacology (15.07.2018)
Published in Neuropharmacology (15.07.2018)
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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na sub(v)1.8 sodium channel with efficacy in a model of neuropathic pain
Scanio, MJ, Shi, L, Drizin, I, Gregg, R J, Atkinson, R N, Thomas, J B, Johnson, MS, Chapman, M L, Liu, D, Krambis, MJ, Liu, Y, Shieh, C C, Zhang, X, Simler, G H, Joshi, S, Honore, P, Marsh, K C, Knox, A, Werness, S, Antonio, B, Krafte, D S, Jarvis, M F, Faltynek, C R, Marron, B E, Kort, ME
Published in Bioorganic & medicinal chemistry (15.11.2010)
Published in Bioorganic & medicinal chemistry (15.11.2010)
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Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain
Drizin, Irene, Gregg, Robert J., Scanio, Marc J.C., Shi, Lei, Gross, Michael F., Atkinson, Robert N., Thomas, James B., Johnson, Matthew S., Carroll, William A., Marron, Brian E., Chapman, Mark L., Liu, Dong, Krambis, Michael J., Shieh, Char-Chang, Zhang, XuFeng, Hernandez, Gricelda, Gauvin, Donna M., Mikusa, Joseph P., Zhu, Chang Z., Joshi, Shailen, Honore, Prisca, Marsh, Kennan C., Roeloffs, Rosemarie, Werness, Stephen, Krafte, Douglas S., Jarvis, Michael F., Faltynek, Connie R., Kort, Michael E.
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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