The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report
Friebe, Andreas, Kraehling, Jan R., Russwurm, Michael, Sandner, Peter, Schmidtko, Achim
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.08.2023)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.08.2023)
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Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation
Ramírez, Cristina M, Zhang, Xinbo, Bandyopadhyay, Chirosree, Rotllan, Noemi, Sugiyama, Michael G, Aryal, Binod, Liu, Xinran, He, Shun, Kraehling, Jan R, Ulrich, Victoria, Lin, Chin Sheng, Velazquez, Heino, Lasunción, Miguel A, Li, Guangxin, Suárez, Yajaira, Tellides, George, Swirski, Filip K, Lee, Warren L, Schwartz, Martin A, Sessa, William C, Fernández-Hernando, Carlos
Published in Circulation (New York, N.Y.) (16.07.2019)
Published in Circulation (New York, N.Y.) (16.07.2019)
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Journal Article
The Impact of the Nitric Oxide (NO)/Soluble Guanylyl Cyclase (sGC) Signaling Cascade on Kidney Health and Disease: A Preclinical Perspective
Krishnan, Shalini M, Kraehling, Jan R, Eitner, Frank, Bénardeau, Agnès, Sandner, Peter
Published in International journal of molecular sciences (09.06.2018)
Published in International journal of molecular sciences (09.06.2018)
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Journal Article
PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia
Ola, Roxana, Dubrac, Alexandre, Han, Jinah, Zhang, Feng, Fang, Jennifer S., Larrivée, Bruno, Lee, Monica, Urarte, Ana A., Kraehling, Jan R., Genet, Gael, Hirschi, Karen K., Sessa, William C., Canals, Francesc V., Graupera, Mariona, Yan, Minhong, Young, Lawrence H., Oh, Paul S., Eichmann, Anne
Published in Nature communications (29.11.2016)
Published in Nature communications (29.11.2016)
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Journal Article
Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells
Kraehling, Jan R., Chidlow, John H., Rajagopal, Chitra, Sugiyama, Michael G., Fowler, Joseph W., Lee, Monica Y., Zhang, Xinbo, Ramírez, Cristina M., Park, Eon Joo, Tao, Bo, Chen, Keyang, Kuruvilla, Leena, Larriveé, Bruno, Folta-Stogniew, Ewa, Ola, Roxana, Rotllan, Noemi, Zhou, Wenping, Nagle, Michael W., Herz, Joachim, Williams, Kevin Jon, Eichmann, Anne, Lee, Warren L., Fernández-Hernando, Carlos, Sessa, William C.
Published in Nature communications (21.11.2016)
Published in Nature communications (21.11.2016)
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Journal Article
A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity
Grabińska, Kariona A., Edani, Ban H., Park, Eon Joo, Kraehling, Jan R., Sessa, William C.
Published in The Journal of biological chemistry (20.10.2017)
Published in The Journal of biological chemistry (20.10.2017)
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Journal Article
The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats
Kraehling, Jan R, Benardeau, Agnes, Schomber, Tibor, Popp, Laura, Vienenkoetter, Julia, Ellinger-Ziegelbauer, Heidrun, Pavkovic, Mira, Hartmann, Elke, Siudak, Krystyna, Freyberger, Alexius, Hagelschuer, Ina, Mathar, Ilka, Hueser, Joerg, Hahn, Michael G, Geiss, Volker, Eitner, Frank, Sandner, Peter
Published in International journal of molecular sciences (01.09.2023)
Published in International journal of molecular sciences (01.09.2023)
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Journal Article
Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency
Protack, Clinton D., Foster, Trenton R., Hashimoto, Takuya, Yamamoto, Kota, Lee, Monica Y., Kraehling, Jan R., Bai, Hualong, Hu, Haidi, Isaji, Toshihiko, Santana, Jeans M., Wang, Mo, Sessa, William C., Dardik, Alan
Published in Scientific reports (13.11.2017)
Published in Scientific reports (13.11.2017)
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Journal Article
Uncoupling Caveolae From Intracellular Signaling In Vivo
Kraehling, Jan R, Hao, Zhengrong, Lee, Monica Y, Vinyard, David J, Velazquez, Heino, Liu, Xinran, Stan, Radu V, Brudvig, Gary W, Sessa, William C
Published in Circulation research (08.01.2016)
Published in Circulation research (08.01.2016)
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Journal Article
Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys
Tietjen, Gregory T, Hosgood, Sarah A, DiRito, Jenna, Cui, Jiajia, Deep, Deeksha, Song, Eric, Kraehling, Jan R, Piotrowski-Daspit, Alexandra S, Kirkiles-Smith, Nancy C, Al-Lamki, Rafia, Thiru, Sathia, Bradley, J Andrew, Saeb-Parsy, Kourosh, Bradley, John R, Nicholson, Michael L, Saltzman, W Mark, Pober, Jordan S
Published in Science translational medicine (29.11.2017)
Published in Science translational medicine (29.11.2017)
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Journal Article
Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney
Stehle, Daniel, Xu, Min Ze, Schomber, Tibor, Hahn, Michael G., Schweda, Frank, Feil, Susanne, Kraehling, Jan R., Eitner, Frank, Patzak, Andreas, Sandner, Peter, Feil, Robert, Bénardeau, Agnès
Published in British journal of pharmacology (01.06.2022)
Published in British journal of pharmacology (01.06.2022)
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Journal Article
BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells
Tao, Bo, Kraehling, Jan R., Ghaffari, Siavash, Ramirez, Cristina M., Lee, Sungwoon, Fowler, Joseph W., Lee, Warren L., Fernandez-Hernando, Carlos, Eichmann, Anne, Sessa, William C.
Published in The Journal of biological chemistry (25.12.2020)
Published in The Journal of biological chemistry (25.12.2020)
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Journal Article
The amino-terminus of nitric oxide sensitive guanylyl cyclase α₁ does not affect dimerization but influences subcellular localization
Kraehling, Jan R, Busker, Mareike, Haase, Tobias, Haase, Nadine, Koglin, Markus, Linnenbaum, Monika, Behrends, Soenke
Published in PloS one (2011)
Published in PloS one (2011)
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Journal Article
Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease
Bénardeau, Agnès, Kahnert, Antje, Schomber, Tibor, Meyer, Jutta, Pavkovic, Mira, Kretschmer, Axel, Lawrenz, Bettina, Hartmann, Elke, Mathar, Ilka, Hueser, Joerg, Kraehling, Jan R., Eitner, Frank, Hahn, Michael G., Stasch, Johannes-Peter, Sandner, Peter
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.12.2021)
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.12.2021)
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Journal Article
The Renoprotective Effects of the Soluble Guanylate Cyclase (sGC) Activator Runcaciguat Are Associated with Distinct Changes in Renal Gene Expression Profiles: PO0708
Kraehling, Jan R., Ellinger-Ziegelbauer, Heidrun C., Benardeau, Agnes M., Pavkovic, Mira, Mathar, Ilka, Vienenkoetter, Julia, Eitner, Frank, Sandner, Peter
Published in Journal of the American Society of Nephrology (01.10.2021)
Published in Journal of the American Society of Nephrology (01.10.2021)
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Journal Article
The Novel Soluble Guanylyl Cyclase (sGC) Activator Runcaciguat Attenuates Hypertensive Cardiorenal Rat Diseases: PO0645
Benardeau, Agnes M., Stasch, Johannes-Peter, Hahn, Michael G., Meyer, Jutta, Kraehling, Jan R., Eitner, Frank, Sandner, Peter
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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Journal Article
The Novel Soluble Guanylyl Cyclase (sGC) Activator Runcaciguat Improves Cardiorenal Morbidity in a Diabetic Rat Model of CKD: PO0917
Benardeau, Agnes M., Stasch, Johannes-Peter, Hahn, Michael G., Pavkovic, Mira, Mathar, Ilka, Kraehling, Jan R., Eitner, Frank, Sandner, Peter
Published in Journal of the American Society of Nephrology (01.10.2020)
Published in Journal of the American Society of Nephrology (01.10.2020)
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