Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560)
Ledneczki, István, Némethy, Zsolt, Molnár, Katalin Dudásné, Tapolcsányi, Pál, Ilkei, Viktor, Vágó, István, Kolok, Sándor, Thán, Márta, Laszy, Judit, Balázs, Ottilia, Krámos, Balázs, Szigetvári, Áron, Bata, Imre, Makó, Attila, Visegrády, András, Fodor, László, Vastag, Mónika, Lévay, György, Lendvai, Balázs, Greiner, István, Éles, János
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Novel-Type GABAB PAMs: Structure–Activity Relationship in Light of the Protein Structure
Krámos, Balázs, Hadady, Zsuzsa, Makó, Attila, Szántó, Gábor, Felföldi, Nóra, Magdó, Ildikó, Bobok, Amrita Ágnes, Bata, Imre, Román, Viktor, Visegrády, András, Keserű, György M., Greiner, István, Éles, János
Published in ACS medicinal chemistry letters (14.03.2024)
Published in ACS medicinal chemistry letters (14.03.2024)
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Journal Article
Synthesis and Characterization of New V 1A Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers
Szeleczky, Zsolt, Szakács, Zoltán, Bozó, Éva, Baska, Ferenc, Vukics, Krisztina, Lévai, Sándor, Temesvári, Krisztina, Vass, Elemér, Béni, Zoltán, Krámos, Balázs, Magdó, Ildikó, Szántay, Csaba, Kóti, János, Domány-Kovács, Katalin, Greiner, István, Bata, Imre
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
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Journal Article
Synthesis and Characterization of New V1A Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers
Szeleczky, Zsolt, Szakács, Zoltán, Bozó, Éva, Baska, Ferenc, Vukics, Krisztina, Lévai, Sándor, Temesvári, Krisztina, Vass, Elemér, Béni, Zoltán, Krámos, Balázs, Magdó, Ildikó, Szántay, Csaba, Kóti, János, Domány-Kovács, Katalin, Greiner, István, Bata, Imre
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
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Journal Article
Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase
Marton, Lívia, Nagy, Gergely N, Ozohanics, Olivér, Lábas, Anikó, Krámos, Balázs, Oláh, Julianna, Vékey, Károly, Vértessy, Beáta G
Published in PloS one (17.06.2015)
Published in PloS one (17.06.2015)
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Journal Article
Discovery of New Heterocyclic Ring Systems as Novel and Potent V 1A Receptor Antagonists
Baska, Ferenc, Szántó, Gábor, Bozó, Éva, Szakács, Zoltán, Dékány, Miklós, Szondiné Kordás, Krisztina, Domány-Kovács, Katalin, Kurkó, Dalma, Hodoscsek, Barbara, Magdó, Ildikó, Krámos, Balázs, Béni, Zoltán, Vastag, Mónika, Bata, Imre
Published in ACS chemical neuroscience (04.11.2020)
Published in ACS chemical neuroscience (04.11.2020)
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Journal Article
Discovery of New Heterocyclic Ring Systems as Novel and Potent V1A Receptor Antagonists
Baska, Ferenc, Szántó, Gábor, Bozó, Éva, Szakács, Zoltán, Dékány, Miklós, Szondiné Kordás, Krisztina, Domány-Kovács, Katalin, Kurkó, Dalma, Hodoscsek, Barbara, Magdó, Ildikó, Krámos, Balázs, Béni, Zoltán, Vastag, Mónika, Bata, Imre
Published in ACS chemical neuroscience (04.11.2020)
Published in ACS chemical neuroscience (04.11.2020)
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Journal Article
Correction: Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase
Marton, Lívia, Nagy, Gergely N, Ozohanics, Olivér, Lábas, Anikó, Krámos, Balázs, Oláh, Julianna, Vékey, Károly, Vértessy, Beáta G
Published in PloS one (27.10.2016)
Published in PloS one (27.10.2016)
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Journal Article
Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum
Nagy, Gergely N., Marton, Lívia, Krámos, Balázs, Oláh, Julianna, Révész, Ágnes, Vékey, Károly, Delsuc, Frédéric, Hunyadi‐Gulyás, Éva, Medzihradszky, Katalin F., Lavigne, Marina, Vial, Henri, Cerdan, Rachel, Vértessy, Beáta G.
Published in The FEBS journal (01.07.2013)
Published in The FEBS journal (01.07.2013)
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Journal Article
Synthesis and pKa determination of new enantiopure dimethyl‐substituted acridino‐crown ethers containing a carboxyl group: Useful candidates for enantiomeric recognition studies
Németh, Tamás, Dargó, Gergő, Petró, József Levente, Petrik, Zsófia, Lévai, Sándor, Krámos, Balázs, Béni, Zoltán, Nagy, József, Balogh, György Tibor, Huszthy, Péter, Tóth, Tünde
Published in Chirality (New York, N.Y.) (01.09.2017)
Published in Chirality (New York, N.Y.) (01.09.2017)
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Journal Article
Novel imidazo[1,5-a]quinoxaline derivatives: SAR, selectivity and modeling challenges en route to the identification of an α5-GABAA receptor NAM
Károlyi, Benedek Imre, Potor, Attila, Kapus, Gábor László, Fodor, László, Bobok, Amrita, Krámos, Balázs, Magdó, Ildikó, Bata, Imre, Szabó, György
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
Published in Bioorganic & medicinal chemistry letters (15.01.2023)
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Journal Article
Novel-Type GABA B PAMs: Structure-Activity Relationship in Light of the Protein Structure
Krámos, Balázs, Hadady, Zsuzsa, Makó, Attila, Szántó, Gábor, Felföldi, Nóra, Magdó, Ildikó, Bobok, Amrita Ágnes, Bata, Imre, Román, Viktor, Visegrády, András, Keserű, György M, Greiner, István, Éles, János
Published in ACS medicinal chemistry letters (14.03.2024)
Published in ACS medicinal chemistry letters (14.03.2024)
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Journal Article
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor
Ledneczki, István, Horváth, Anita, Tapolcsányi, Pál, Éles, János, Molnár, Katalin Dudás, Vágó, István, Visegrády, András, Kiss, László, Szigetvári, Áron, Kóti, János, Krámos, Balázs, Mahó, Sándor, Holm, Patrik, Kolok, Sándor, Fodor, László, Thán, Márta, Kostyalik, Diána, Balázs, Ottilia, Vastag, Mónika, Greiner, István, Lévay, György, Lendvai, Balázs, Némethy, Zsolt
Published in European journal of medicinal chemistry (15.10.2021)
Published in European journal of medicinal chemistry (15.10.2021)
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Journal Article
Direct Hydride Shift Mechanism and Stereoselectivity of P450 nor Confirmed by QM/MM Calculations
Krámos, Balázs, Menyhárd, Dóra K., Oláh, Julianna
Published in The journal of physical chemistry. B (19.01.2012)
Published in The journal of physical chemistry. B (19.01.2012)
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Journal Article
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach
Ledneczki, István, Tapolcsányi, Pál, Gábor, Eszter, Visegrády, András, Vass, Márton, Éles, János, Holm, Patrik, Horváth, Anita, Pocsai, Anikó, Mahó, Sándor, Greiner, István, Krámos, Balázs, Béni, Zoltán, Kóti, János, Káncz, Anna E., Thán, Márta, Kolok, Sándor, Laszy, Judit, Balázs, Ottilia, Bugovits, Gyula, Nagy, József, Vastag, Mónika, Szájli, Ágota, Bozó, Éva, Lévay, György, Lendvai, Balázs, Némethy, Zsolt
Published in European journal of medicinal chemistry (15.03.2021)
Published in European journal of medicinal chemistry (15.03.2021)
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Journal Article
Synthesis, experimental and theoretical studies on the factors influencing the pKa values of new crown ethers containing a diarylphosphinic acid unit
Szabó, Tamás, Dargó, Gergő, Szentjóbi, Hajnalka, Tóth, Tünde, Krámos, Balázs, Izrael, Richárd, Oláh, Julianna, Németh, Tamás, Balogh, György T., Huszthy, Péter
Published in Tetrahedron (29.12.2016)
Published in Tetrahedron (29.12.2016)
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Journal Article
Neuronal Dopamine D3 Receptors: Translational Implications for Preclinical Research and CNS Disorders
Kiss, Béla, Laszlovszky, István, Krámos, Balázs, Visegrády, András, Bobok, Amrita, Lévay, György, Lendvai, Balázs, Román, Viktor
Published in Biomolecules (Basel, Switzerland) (14.01.2021)
Published in Biomolecules (Basel, Switzerland) (14.01.2021)
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Journal Article
Combined Docking and Quantum Chemical Study on CYP-Mediated Metabolism of Estrogens in Man
Labas, Aniko, Kramos, Balazs, Olah, Julianna
Published in Chemical research in toxicology (20.02.2017)
Published in Chemical research in toxicology (20.02.2017)
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