Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
Carracedo, Arkaitz, Ma, Li, Teruya-Feldstein, Julie, Rojo, Federico, Salmena, Leonardo, Alimonti, Andrea, Egia, Ainara, Sasaki, Atsuo T, Thomas, George, Kozma, Sara C, Papa, Antonella, Nardella, Caterina, Cantley, Lewis C, Baselga, Jose, Pandolfi, Pier Paolo
Published in The Journal of clinical investigation (01.09.2008)
Published in The Journal of clinical investigation (01.09.2008)
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Journal Article
Mitochondrial Complex I Activity Is Required for Maximal Autophagy
Thomas, Hala Elnakat, Zhang, Yu, Stefely, Jonathan A., Veiga, Sonia R., Thomas, George, Kozma, Sara C., Mercer, Carol A.
Published in Cell reports (Cambridge) (28.08.2018)
Published in Cell reports (Cambridge) (28.08.2018)
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Journal Article
Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
Stoica, Loredana, Zhu, Ping Jun, Huang, Wei, Zhou, Hongyi, Kozma, Sara C, Costa-Mattioli, Mauro
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2011)
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Journal Article
Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes
Gentilella, Antonio, Morón-Duran, Francisco D., Fuentes, Pedro, Zweig-Rocha, Guilherme, Riaño-Canalias, Ferran, Pelletier, Joffrey, Ruiz, Marta, Turón, Gemma, Castaño, Julio, Tauler, Albert, Bueno, Clara, Menéndez, Pablo, Kozma, Sara C., Thomas, George
Published in Molecular cell (06.07.2017)
Published in Molecular cell (06.07.2017)
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Journal Article
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, Colin, Tullet, Jennifer M.A, Wieser, Daniela, Irvine, Elaine, Lingard, Steven J, Choudhury, Agharul I, Claret, Marc, Al-Qassab, Hind, Carmignac, Danielle, Ramadani, Faruk, Woods, Angela, Robinson, Iain C.A, Schuster, Eugene, Batterham, Rachel L, Kozma, Sara C, Thomas, George, Carling, David, Okkenhaug, Klaus, Thornton, Janet M, Partridge, Linda, Gems, David, Withers, Dominic J
Published in Science (American Association for the Advancement of Science) (02.10.2009)
Published in Science (American Association for the Advancement of Science) (02.10.2009)
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Journal Article
Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection
Pardo, Virginia, González-Rodríguez, Águeda, Muntané, Jordi, Kozma, Sara C., Valverde, Ángela M.
Published in Food and chemical toxicology (01.06.2015)
Published in Food and chemical toxicology (01.06.2015)
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Journal Article
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34
Gulati, Pawan, Gaspers, Lawrence D, Dann, Stephen G, Joaquin, Manel, Nobukuni, Takahiro, Natt, Francois, Kozma, Sara C, Thomas, Andrew P, Thomas, George
Published in Cell metabolism (01.05.2008)
Published in Cell metabolism (01.05.2008)
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Journal Article
S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis
Yi, Sang Ah, Um, Sung Hee, Lee, Jaecheol, Yoo, Ji Hee, Bang, So Young, Park, Eun Kyung, Lee, Min Gyu, Nam, Ki Hong, Jeon, Ye Ji, Park, Jong Woo, You, Jueng Soo, Lee, Sang-Jin, Bae, Gyu-Un, Rhie, Jong Won, Kozma, Sara C., Thomas, George, Han, Jeung-Whan
Published in Molecular cell (05.05.2016)
Published in Molecular cell (05.05.2016)
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Journal Article
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
Carnevalli, Larissa S., Masuda, Kouhei, Frigerio, Francesca, Le Bacquer, Olivier, Um, Sung Hee, Gandin, Valentina, Topisirovic, Ivan, Sonenberg, Nahum, Thomas, George, Kozma, Sara C.
Published in Developmental cell (18.05.2010)
Published in Developmental cell (18.05.2010)
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Journal Article
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
Risson, Valérie, Mazelin, Laetitia, Roceri, Mila, Sanchez, Hervé, Moncollin, Vincent, Corneloup, Claudine, Richard-Bulteau, Hélène, Vignaud, Alban, Baas, Dominique, Defour, Aurélia, Freyssenet, Damien, Tanti, Jean-François, Le-Marchand-Brustel, Yannick, Ferrier, Bernard, Conjard-Duplany, Agnès, Romanino, Klaas, Bauché, Stéphanie, Hantaï, Daniel, Mueller, Matthias, Kozma, Sara C, Thomas, George, Rüegg, Markus A, Ferry, Arnaud, Pende, Mario, Bigard, Xavier, Koulmann, Nathalie, Schaeffer, Laurent, Gangloff, Yann-Gaël
Published in The Journal of cell biology (14.12.2009)
Published in The Journal of cell biology (14.12.2009)
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Journal Article
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.]
Um, S.H, Frigerio, F, Watanabe, M, Picard, F, Joaquin, M, Sticker, M, Fumagalli, S, Allegrini, P.R, Kozma, S.C, Auwerx, J
Published in Nature (09.09.2004)
Published in Nature (09.09.2004)
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Journal Article
Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth
Zhu, Yi, Pires, Karla M P, Whitehead, Kevin J, Olsen, Curtis D, Wayment, Benjamin, Zhang, Yi Cheng, Bugger, Heiko, Ilkun, Olesya, Litwin, Sheldon E, Thomas, George, Kozma, Sara C, Abel, E Dale
Published in PloS one (14.01.2013)
Published in PloS one (14.01.2013)
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Journal Article
S6K1−/−/S6K2−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
Pende, Mario, Um, Sung Hee, Mieulet, Virginie, Sticker, Melanie, Goss, Valerie L., Mestan, Jurgen, Mueller, Matthias, Fumagalli, Stefano, Kozma, Sara C., Thomas, George
Published in Molecular and Cellular Biology (01.04.2004)
Published in Molecular and Cellular Biology (01.04.2004)
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Journal Article
S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3
Wang, Fuan, Alain, Tommy, Szretter, Kristy J, Stephenson, Kyle, Pol, Jonathan G, Atherton, Matthew J, Hoang, Huy-Dung, Fonseca, Bruno D, Zakaria, Chadi, Chen, Lan, Rangwala, Zainab, Hesch, Adam, Chan, Eva Sin Yan, Tuinman, Carly, Suthar, Mehul S, Jiang, Zhaozhao, Ashkar, Ali A, Thomas, George, Kozma, Sara C, Gale, Michael, Fitzgerald, Katherine A, Diamond, Michael S, Mossman, Karen, Sonenberg, Nahum, Wan, Yonghong, Lichty, Brian D
Published in Nature immunology (01.05.2016)
Published in Nature immunology (01.05.2016)
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Journal Article
hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling
Nobukuni, Takahiro, Kozma, Sara C, Thomas, George
Published in Current opinion in cell biology (01.04.2007)
Published in Current opinion in cell biology (01.04.2007)
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Journal Article
Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2
Garami, Attila, Zwartkruis, Fried J.T, Nobukuni, Takahiro, Joaquin, Manel, Roccio, Marta, Stocker, Hugo, Kozma, Sara C, Hafen, Ernst, Bos, Johannes L, Thomas, George
Published in Molecular cell (01.06.2003)
Published in Molecular cell (01.06.2003)
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Journal Article
mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma
Thomas, Hala Elnakat, Mercer, Carol A, Carnevalli, Larissa S, Park, Jongsun, Andersen, Jesper B, Conner, Elizabeth A, Tanaka, Kazuhiro, Matsutani, Tomoo, Iwanami, Akio, Aronow, Bruce J, Manway, Liu, Maira, S Michel, Thorgeirsson, Snorri S, Mischel, Paul S, Thomas, George, Kozma, Sara C
Published in Science translational medicine (20.06.2012)
Published in Science translational medicine (20.06.2012)
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Journal Article
Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production
Alain, Tommy, Lun, XueQing, Martineau, Yvan, Sean, Polen, Pulendran, Bali, Petroulakis, Emmanuel, Zemp, Franz J, Lemay, Chantal G, Roy, Dominic, Bell, John C, Thomas, George, Kozma, Sara C, Forsyth, Peter A, Costa-Mattioli, Mauro, Sonenberg, Nahum
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (26.01.2010)
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Journal Article
V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy
Meo-Evoli, Nathalie, Almacellas, Eugènia, Massucci, Francesco Alessandro, Gentilella, Antonio, Ambrosio, Santiago, Kozma, Sara C, Thomas, George, Tauler, Albert
Published in Oncotarget (29.09.2015)
Published in Oncotarget (29.09.2015)
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